B8CR57 (PUR7_SHEPW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	swp_3011

Organism

Shewanella piezotolerans (strain WP3 / JCM 13877) [Complete proteome] [HAMAP]

Taxonomic identifier

225849 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000117852

Sequences

	Sequence		Length	Mass (Da)
	B8CR57 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: EE053A051C4647E4	FASTA	367	41,309
	10 20 30 40 50 60 MNLADKVLVV NDNLPIRTDK PVHSGKVRSV YWLTPEDSAR LIKDKGYDVP ADAPLAIMVI 70 80 90 100 110 120 SDRISAFDCV WQGENGLNGV PGKGTALNAI SNHWFKLFKE KGLADSHILD IPHPLVWIVQ 130 140 150 160 170 180 KARPVMIEAI ARQYITGSMW RSYTKGEREF CGITIPEGLE KDQKLPELLI TPSTKGVLTG 190 200 210 220 230 240 LEGVPEADDV NVSRSDIERH VDGFNFSSLS DIDLYEKLLK EGFDVISDAL AEHDQIFVDT 250 260 270 280 290 300 KFEFGYVNDA AGNEKLIYMD EVGTPDSSRI WDGSSHRDGK IIEQSKEGFR QWLLNHFPDA 310 320 330 340 350 360 DILLNKNRME ERFALAKDNK LPESVMMDIS NTYVGIAEKV IGEKLHISEN PKQEIIDILR SEYQLIV

References

[1]

"Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3." Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X. PLoS ONE 3:E1937-E1937(2008) [PubMed: 18398463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: WP3 / JCM 13877.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000472 Genomic DNA. Translation: ACJ29729.1.
RefSeq	YP_002312316.1. NC_011566.1.
3D structure databases
ProteinModelPortal	B8CR57.
ModBase	Search...
Protein-protein interaction databases
STRING	B8CR57.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7034014.
GenomeReviews	Gene locus swp_3011 in contig CP000472_GR.
KEGG	swp:swp_3011.
PATRIC	23544502. VBIShePie65056_2767.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG555040.
OMA	SSRIWDG.
ProtClustDB	PRK13960.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR014106. PurC_vibrio. IPR001636. SAICAR_synth. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02735. PurC_vibrio. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. False negative. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_SHEPW

Accession

Primary (citable) accession number: B8CR57

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program