B8CQ73 (B8CQ73_SHEPW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387
Short name=UDP-N-acetylglucosamine acyltransferase HAMAP MF_00387
EC=2.3.1.129 HAMAP MF_00387

Gene names

Name:	lpxA HAMAP MF_00387
Ordered Locus Names:	swp_3509

Organism

Shewanella piezotolerans (strain WP3 / JCM 13877) [Complete proteome] [HAMAP] EMBL ACJ30203.1

Taxonomic identifier

225849 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387
Subunit structure	Homotrimer By similarity. HAMAP MF_00387
Subcellular location	Cytoplasm By similarity HAMAP MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily. HAMAP MF_00387

Ontologies

Keywords
Biological process	Lipid A biosynthesis HAMAP MF_00387 Lipid synthesis
Cellular component	Cytoplasm HAMAP MF_00387
Domain	Repeat HAMAP MF_00387
Molecular function	Acyltransferase HAMAP MF_00387 EMBL ACJ30203.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8CQ73 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 53DAD62BF5365951	FASTA	256	27,934
	10 20 30 40 50 60 MIDKLAYIHP DAKIGNNVTI GPWTYIGADV EIGDDCWFSS HVVVKGPTVI GKGNKFYQFA 70 80 90 100 110 120 SVGEDCQDKK FAGEATRLII GDNNVIRESV TIHRGTTQDN WETRIGSNNL FMAYVHIAHD 130 140 150 160 170 180 CVVGNNVIMS NNASIAGHVH VGDYAILGGM TGVHQFVKIG AHAFTAGYSL ILNDVPPFVM 190 200 210 220 230 240 ASGQPAVPRG LNSEGLKRRG FSKESQLAVR RAYKTLYRNG LTVEEAVEQL KEAAEDDEQV 250 KLLVDFIASS NRGIVR

References

[1]

"Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3." Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X. PLoS ONE 3:E1937-E1937(2008) [PubMed: 18398463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: WP3 EMBL ACJ30203.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000472 Genomic DNA. Translation: ACJ30203.1.
RefSeq	YP_002312790.1. NC_011566.1.
3D structure databases
ProteinModelPortal	B8CQ73.
ModBase	Search...
Protein-protein interaction databases
STRING	B8CQ73.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7034488.
GenomeReviews	Gene locus swp_3509 in contig CP000472_GR.
KEGG	swp:swp_3509.
PATRIC	23545424. VBIShePie65056_3225.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG659295.
OMA	REFCTFN.
ProtClustDB	PRK05289.
Family and domain databases
HAMAP	MF_00387. LpxA. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00677.
Pfam	PF00132. Hexapep. 5 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. Lipid_A_lpxA. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8CQ73_SHEPW

Accession

Primary (citable) accession number: B8CQ73

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)