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B8CNI0

- ASSY_SHEPW

UniProt

B8CNI0 - ASSY_SHEPW

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei96 – 961CitrullineUniRule annotation
Binding sitei101 – 1011CitrullineUniRule annotation
Binding sitei126 – 1261ATP; via amide nitrogenUniRule annotation
Binding sitei128 – 1281AspartateUniRule annotation
Binding sitei132 – 1321AspartateUniRule annotation
Binding sitei132 – 1321CitrullineUniRule annotation
Binding sitei133 – 1331AspartateUniRule annotation
Binding sitei136 – 1361CitrullineUniRule annotation
Binding sitei185 – 1851CitrullineUniRule annotation
Binding sitei194 – 1941CitrullineUniRule annotation
Binding sitei270 – 2701CitrullineUniRule annotation
Binding sitei282 – 2821CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 249ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPIE225849:GH6V-2003-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:swp_2058
OrganismiShewanella piezotolerans (strain WP3 / JCM 13877)
Taxonomic identifieri225849 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000753: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Argininosuccinate synthasePRO_1000116193Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi225849.swp_2058.

Structurei

3D structure databases

ProteinModelPortaliB8CNI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8CNI0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAETKKTDV KKVVLAYSGG LDTSAIIPWL KETYDNCEIV AFCADVGQGS
60 70 80 90 100
EELEGLHEKA IASGASECYI VDLKEELVAD YIYPTIATGA IYEGTYLLGT
110 120 130 140 150
SMARPIIAKA QVEVARKVGA DAVCHGCTGK GNDQVRFEGC FAALAPDLKV
160 170 180 190 200
IAPWREWEMV SREDLLDYLA ERNIETTASA TKIYSRDANA WHISHEGGEL
210 220 230 240 250
EDPWNEPTQG VWTMTVAPED APNTPEYVAL ELEQGKITKV NGEALSPYKA
260 270 280 290 300
LMLLNDLAGA HGVGRIDITE NRLVGMKSRG CYETPGGTVM FAALRAIEEL
310 320 330 340 350
VLDKTSREWR EQVGAQMAHL VYDGRWFTPL CESLLGASKP LADLVNGEVV
360 370 380 390 400
IKLYKGQASA VKKRSPNSLY SEEFATFGED DVYNQKDAEG FIRLYSLSSR

IRALHGHNK
Length:409
Mass (Da):44,884
Last modified:March 3, 2009 - v1
Checksum:i1A3990A51BC7234B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000472 Genomic DNA. Translation: ACJ28814.1.
RefSeqiYP_002311401.1. NC_011566.1.

Genome annotation databases

EnsemblBacteriaiACJ28814; ACJ28814; swp_2058.
GeneIDi7033099.
KEGGiswp:swp_2058.
PATRICi23542674. VBIShePie65056_1884.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000472 Genomic DNA. Translation: ACJ28814.1 .
RefSeqi YP_002311401.1. NC_011566.1.

3D structure databases

ProteinModelPortali B8CNI0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 225849.swp_2058.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ28814 ; ACJ28814 ; swp_2058 .
GeneIDi 7033099.
KEGGi swp:swp_2058.
PATRICi 23542674. VBIShePie65056_1884.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SPIE225849:GH6V-2003-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3."
    Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X.
    PLoS ONE 3:E1937-E1937(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WP3 / JCM 13877.

Entry informationi

Entry nameiASSY_SHEPW
AccessioniPrimary (citable) accession number: B8CNI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3