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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (purL)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPIE225849:G1G7F-1633-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:swp_1818
OrganismiShewanella piezotolerans (strain WP3 / JCM 13877)
Taxonomic identifieri225849 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000000753 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001482971 – 346Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST346

Interactioni

Protein-protein interaction databases

STRINGi225849.swp_1818.

Structurei

3D structure databases

ProteinModelPortaliB8CN80.
SMRiB8CN80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB. Bacteria.
COG0150. LUCA.
HOGENOMiHOG000229090.
KOiK01933.
OMAiNHCVNDI.
OrthoDBiPOG091H0128.

Family and domain databases

CDDicd02196. PurM. 1 hit.
Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS. 1 hit.
InterProiView protein in InterPro
IPR010918. PurM-like_C_dom.
IPR036676. PurM-like_C_sf.
IPR016188. PurM-like_N.
IPR036921. PurM-like_N_sf.
IPR004733. PurM_cligase.
PANTHERiPTHR10520. PTHR10520. 1 hit.
PfamiView protein in Pfam
PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B8CN80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPTTPLSY KDAGVDIDAG NALVNNIKSA VKRTRRPEVM GNLGGFGALC
60 70 80 90 100
ELPTKYKHPV LVSGTDGVGT KLRLAIDYKK HDNVGVDLVA MCSNDLIVSG
110 120 130 140 150
AEPLFFLDYY ATGKLDVEVA TAVVKGIAEG CVQSGCALIG GETAEMPGMY
160 170 180 190 200
EGDDYDLAGF CVGVAEKEEI IDGTKVQDGD ALIALASSGP HSNGFSLIRK
210 220 230 240 250
VLEVSKADPE QELAGKPLID HLLEPTKIYV KSLLKLIEEH DVHAMSHITG
260 270 280 290 300
GGFWENIPRV LPEDCKAVVK SDSWQWPVVF NWLMEKGNIS EFEMYRTFNC
310 320 330 340
GVGMVVALPA DKVESALNLL NAEGEKAWLI GDIAKRSGDE EQVEIL
Length:346
Mass (Da):37,286
Last modified:March 3, 2009 - v1
Checksum:i7E4E8F6758A56597
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000472 Genomic DNA. Translation: ACJ28582.1.
RefSeqiWP_020911960.1. NC_011566.1.

Genome annotation databases

EnsemblBacteriaiACJ28582; ACJ28582; swp_1818.
KEGGiswp:swp_1818.

Similar proteinsi

Entry informationi

Entry nameiPUR5_SHEPW
AccessioniPrimary (citable) accession number: B8CN80
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome