B8CM24 (B8CM24_SHEPW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1 2 HAMAP MF_00223
EC=3.5.4.16 HAMAP MF_00223

Alternative name(s):
GTP cyclohydrolase I 2 HAMAP MF_00223

Gene names

Name:	folE2 HAMAP MF_00223
Ordered Locus Names:	swp_2198

Organism

Shewanella piezotolerans (strain WP3 / JCM 13877) [Complete proteome] [HAMAP] EMBL ACJ28948.1

Taxonomic identifier

225849 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family. HAMAP MF_00223

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_00223
Ligand	GTP-binding HAMAP MF_00223 Metal-binding HAMAP MF_00223 Nucleotide-binding Zinc HAMAP MF_00223
Molecular function	Hydrolase HAMAP MF_00223 EMBL ACJ28948.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	113	1	Zinc By similarity HAMAP MF_00223
	Metal binding	116	1	Zinc By similarity HAMAP MF_00223
	Metal binding	184	1	Zinc By similarity HAMAP MF_00223

Sequences

	Sequence		Length	Mass (Da)
	B8CM24 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 1624431E812A5ED7	FASTA	219	24,791
	10 20 30 40 50 60 MTSKEAILSE SAQLVQTALL ERGLETPMLP SEFTREERKD KIEHHMREIL TLMSLDLRDD 70 80 90 100 110 120 SLEETPRRIA KMYVDEIFSG LDYANFPKIT VIENKMGFDE MVKVNDISLT STCEHHLVTI 130 140 150 160 170 180 DGLARVAYLP RKNIIGLSKI NRIVRFFAQR PQVQERLTQQ VLVALQTLLE TKDVAVKMDA 190 200 210 VHYCVKSRGV MDSTSSTTTT ALGGIFKSNP ATRAEFLSN

References

[1]

"Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3." Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X. PLoS ONE 3:E1937-E1937(2008) [PubMed: 18398463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: WP3 EMBL ACJ28948.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000472 Genomic DNA. Translation: ACJ28948.1.
RefSeq	YP_002311535.1. NC_011566.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8CM24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7033233.
GenomeReviews	Gene locus swp_2198 in contig CP000472_GR.
KEGG	swp:swp_2198.
PATRIC	23542942. VBIShePie65056_2018.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG370191.
OMA	PTRIAKM.
ProtClustDB	PRK09347.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8CM24_SHEPW

Accession

Primary (citable) accession number: B8CM24

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)