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B8CKS7

- B8CKS7_SHEPW

UniProt

B8CKS7 - B8CKS7_SHEPW

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Protein

Phosphoribosylformylglycinamidine synthase

Gene
purL, swp_1467
Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate By similarity.UniRule annotation

Catalytic activityi

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei676 – 6761ATP; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi677 – 6771Magnesium By similarityUniRule annotation
Metal bindingi716 – 7161Magnesium By similarityUniRule annotation
Metal bindingi720 – 7201Magnesium By similarityUniRule annotation
Metal bindingi884 – 8841Magnesium By similarityUniRule annotation
Binding sitei886 – 8861ATP By similarityUniRule annotation
Active sitei1133 – 11331Nucleophile By similarityUniRule annotation
Active sitei1258 – 12581 By similarityUniRule annotation
Active sitei1260 – 12601 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi305 – 31612ATP By similarityUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. phosphoribosylformylglycinamidine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPIE225849:GH6V-1415-MONOMER.
UniPathwayiUPA00074; UER00128.

Protein family/group databases

MEROPSiC56.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine synthaseUniRule annotation (EC:6.3.5.3UniRule annotation)
Short name:
FGAM synthaseUniRule annotation
Short name:
FGAMSUniRule annotation
Alternative name(s):
Formylglycinamide ribonucleotide amidotransferase
Gene namesi
Name:purLUniRule annotation
Ordered Locus Names:swp_1467Imported
OrganismiShewanella piezotolerans (strain WP3 / JCM 13877)Imported
Taxonomic identifieri225849 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000753: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi225849.swp_1467.

Structurei

3D structure databases

ProteinModelPortaliB8CKS7.

Family & Domainsi

Sequence similaritiesi

Contains glutamine amidotransferase type-1 domain.SAAS annotations
Contains glutamine amidotransferase type-domain.SAAS annotations
In the N-terminal section; belongs to the FGAMS family.UniRule annotation

Keywords - Domaini

Glutamine amidotransferaseUniRule annotationSAAS annotations

Phylogenomic databases

eggNOGiCOG0046.
HOGENOMiHOG000261359.
KOiK01952.
OMAiGEGHAEF.
OrthoDBiEOG6FNHHR.

Family and domain databases

Gene3Di3.30.1330.10. 2 hits.
3.40.50.880. 1 hit.
HAMAPiMF_00419. PurL_1.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
TIGRFAMsiTIGR01735. FGAM_synt. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8CKS7-1 [UniParc]FASTAAdd to Basket

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MEIIRGAPAL SAFRVQKLMQ ACESAALPVR QIYAEFIHLA DLKESLEENE     50
SQQLEKILTY GPAIEAHQPE GKLHFVTPRP GTISPWSSKA TDIAHNCGLD 100
KVLRLERGIA YYVVADELTA AQTKSLLELL HDRMVEVVVN DFNAADVLFA 150
RTEPAKFKSV DILGQGRSAL ELANTTLGLA LAEDEIDYLV ENFKRLERNP 200
NDVELMMFAQ ANSEHCRHKI FNADWTIDGE VQPKSLFKMI KNTFETTPEN 250
VLSAYKDNAA VMTGSTAGRF FPKQDGVYGY HTEPMHILMK VETHNHPTAI 300
SPYPGAATGS GGEIRDEGAT GRGSKPKAGL TGFSVSNLKI PGFVQPWEAD 350
YGKPDRIVTA LDIMTEGPLG GAAFNNEFGR PALVGYFRTY EQEVNSHNGV 400
EVRGYHKPIM LAGGLGNIRE EHVQKGEITV GAKLVVLGGP AMNIGLGGGA 450
ASSMTSGQSS EDLDFASVQR ENPEMERRCQ EVIDRCWQMG DANPIQFIHD 500
VGAGGLSNAF PELVDDGGRG GNFELRRVPS DEPGMSPLEI WCNESQERYV 550
MSIAPENLAV FTAICQRERA PFAVVGVATE ERELILSDEH FENHPIELPL 600
EVLLGKAPKM SRDVVSAKAN SSALDQSDIA VKEAAHRLLR LPTIAEKTFL 650
ITIGDRTVTG LVNRDQMVGP WQVPVADCAV TAASYDSYVG EAMSIGERTP 700
LALLDFGASA RMAVAESILN IAGTDIGSFK RIKLSANWMS PAGHPGEDAG 750
LYEAVKAIGE ELCPDLSLTI PVGKDSMSMK TAWEDNGVQK AVTSPMSLVI 800
TAFGVVQDVR NTVTPELRSD KGDSELLLLD LGLGQNRLGG SCLAQVYSEL 850
GDIAPDLDNS ATLKGFFEVI QPLVADQSIL AYHDRSDGGL YTTLVEMAFA 900
GHTGLNVDLS ALTGTDVERL FNEELGAVIQ VRREDSAAIS AKFNAAGVAC 950
HKVAELTDTD QIAIFDGERE VLTETRTSLR TIWAETTYRM QSLRDNPECA 1000
KEEHALKQDA NDLGLTVDLS FDPSEDVAAP FILKGAAPKM AILREQGVNS 1050
HIEMAAAFDR AGFESKDVHM SDILSGRISL EEFQGLVACG GFSYGDVLGA 1100
GEGWAKSILF NARAREQFSQ FFERDDSFSL GVCNGCQMLS NLKDIIPGTD 1150
LWPHFVRNRS ERFEARFSLV EVQKSPSLFF QGMEGSRMPI AVSHGEGRAE 1200
FASPEALAAA EASGTIALRY VDGNGQIATQ YPQNPNGSPN AITALSSTDG 1250
RVTIMMPHPE RVFRTVANSW HPDSWGEDSP WMRMFRNVRK SIG 1293
Length:1,293
Mass (Da):140,704
Last modified:March 3, 2009 - v1
Checksum:i43C61359F178E86F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000472 Genomic DNA. Translation: ACJ28253.1.
RefSeqiYP_002310840.1. NC_011566.1.

Genome annotation databases

EnsemblBacteriaiACJ28253; ACJ28253; swp_1467.
GeneIDi7032538.
KEGGiswp:swp_1467.
PATRICi23541531. VBIShePie65056_1341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000472 Genomic DNA. Translation: ACJ28253.1 .
RefSeqi YP_002310840.1. NC_011566.1.

3D structure databases

ProteinModelPortali B8CKS7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 225849.swp_1467.

Protein family/group databases

MEROPSi C56.972.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ28253 ; ACJ28253 ; swp_1467 .
GeneIDi 7032538.
KEGGi swp:swp_1467.
PATRICi 23541531. VBIShePie65056_1341.

Phylogenomic databases

eggNOGi COG0046.
HOGENOMi HOG000261359.
KOi K01952.
OMAi GEGHAEF.
OrthoDBi EOG6FNHHR.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00128 .
BioCyci SPIE225849:GH6V-1415-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 2 hits.
3.40.50.880. 1 hit.
HAMAPi MF_00419. PurL_1.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR010073. PRibForGlyAmidine_synth.
IPR022940. PRibForGlyAmidine_synth_bac.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 2 hits.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF55326. SSF55326. 2 hits.
SSF56042. SSF56042. 2 hits.
TIGRFAMsi TIGR01735. FGAM_synt. 1 hit.
PROSITEi PS51273. GATASE_TYPE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3."
    Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X.
    PLoS ONE 3:E1937-E1937(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WP3 / JCM 13877.

Entry informationi

Entry nameiB8CKS7_SHEPW
AccessioniPrimary (citable) accession number: B8CKS7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In Gram-negative bacteria and most eukaryotes, FGAM synthase is only formed by PurL, a single polypeptide of 140 kDa (large PurL). However in Gram-positive bacteria and archaebacteria, phosphoribosylformylglycinamidine synthase is composed of three separate proteins: PurL (small PurL), PurQ and PurS By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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