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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPIE225849:GH6V-535-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:swp_0551
OrganismiShewanella piezotolerans (strain WP3 / JCM 13877)
Taxonomic identifieri225849 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000753 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligasePRO_1000196823Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi225849.swp_0551.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8CI99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDINISRK HVCKPIAEIA TNLGIVESEL SVHGANKAKI SLSVTNRLAS
60 70 80 90 100
KPDAKLVIVT AVTPTPYGEG KTVTTVGLTQ AMNAIGVKTC ACIRQPSMGP
110 120 130 140 150
VFGIKGGAAG GGYAQVVPME ELNLHLTGDI HAVSSAHNLA AAAIDARLFH
160 170 180 190 200
ETRLGAIAFT KESGLNAVNI DPENILWRRV VDHNERSLRQ IEVGFGAVNG
210 220 230 240 250
PVHSSGFDIT KASELMAILA LSRDVKDLRQ RVGRLVLALD LVGKPITAED
260 270 280 290 300
IGVAGAMTVI MRDAIEPTLM QTLSGDPCFI HAGPFANIAH GNSSIIADSI
310 320 330 340 350
ASKLADVVVT EAGFGSDMGF EKFSNIKVRE SGYKPSAAVV VVTLRALKAN
360 370 380 390 400
SGIESEVAID QPDMARLEAG FANLQWHINN VHQYGAPVVV AINRFPTDTS
410 420 430 440 450
AELDWLQAKV ATTNAFGCAI SDAFANGAQG AAELAKVVHA ATMVESEFNC
460 470 480 490 500
LYETTDTLES KLMTLAEVGY GAASVSLSDK AKLQLAWLHK QGYSELPVCI
510 520 530 540 550
AKTPMSISHD PNVKGVPRNF ELPINELRLN AGAGFITALV GKVMTMPGLG
560 570
IKPGYLNIDI DADDEIIGLA
Length:570
Mass (Da):60,198
Last modified:March 3, 2009 - v1
Checksum:i602AA4ADA64F3C18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000472 Genomic DNA. Translation: ACJ27375.1.
RefSeqiWP_020910756.1. NC_011566.1.
YP_002309962.1. NC_011566.1.

Genome annotation databases

EnsemblBacteriaiACJ27375; ACJ27375; swp_0551.
KEGGiswp:swp_0551.
PATRICi23539818. VBIShePie65056_0499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000472 Genomic DNA. Translation: ACJ27375.1.
RefSeqiWP_020910756.1. NC_011566.1.
YP_002309962.1. NC_011566.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi225849.swp_0551.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ27375; ACJ27375; swp_0551.
KEGGiswp:swp_0551.
PATRICi23539818. VBIShePie65056_0499.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciSPIE225849:GH6V-535-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3."
    Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X.
    PLoS ONE 3:E1937-E1937(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WP3 / JCM 13877.

Entry informationi

Entry nameiFTHS_SHEPW
AccessioniPrimary (citable) accession number: B8CI99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 27, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.