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B8CI99

- FTHS_SHEPW

UniProt

B8CI99 - FTHS_SHEPW

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, swp_0551
Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPIE225849:GH6V-535-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:swp_0551
OrganismiShewanella piezotolerans (strain WP3 / JCM 13877)
Taxonomic identifieri225849 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000753: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000196823Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi225849.swp_0551.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8CI99-1 [UniParc]FASTAAdd to Basket

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MLSDINISRK HVCKPIAEIA TNLGIVESEL SVHGANKAKI SLSVTNRLAS    50
KPDAKLVIVT AVTPTPYGEG KTVTTVGLTQ AMNAIGVKTC ACIRQPSMGP 100
VFGIKGGAAG GGYAQVVPME ELNLHLTGDI HAVSSAHNLA AAAIDARLFH 150
ETRLGAIAFT KESGLNAVNI DPENILWRRV VDHNERSLRQ IEVGFGAVNG 200
PVHSSGFDIT KASELMAILA LSRDVKDLRQ RVGRLVLALD LVGKPITAED 250
IGVAGAMTVI MRDAIEPTLM QTLSGDPCFI HAGPFANIAH GNSSIIADSI 300
ASKLADVVVT EAGFGSDMGF EKFSNIKVRE SGYKPSAAVV VVTLRALKAN 350
SGIESEVAID QPDMARLEAG FANLQWHINN VHQYGAPVVV AINRFPTDTS 400
AELDWLQAKV ATTNAFGCAI SDAFANGAQG AAELAKVVHA ATMVESEFNC 450
LYETTDTLES KLMTLAEVGY GAASVSLSDK AKLQLAWLHK QGYSELPVCI 500
AKTPMSISHD PNVKGVPRNF ELPINELRLN AGAGFITALV GKVMTMPGLG 550
IKPGYLNIDI DADDEIIGLA 570
Length:570
Mass (Da):60,198
Last modified:March 3, 2009 - v1
Checksum:i602AA4ADA64F3C18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000472 Genomic DNA. Translation: ACJ27375.1.
RefSeqiYP_002309962.1. NC_011566.1.

Genome annotation databases

EnsemblBacteriaiACJ27375; ACJ27375; swp_0551.
GeneIDi7031659.
KEGGiswp:swp_0551.
PATRICi23539818. VBIShePie65056_0499.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000472 Genomic DNA. Translation: ACJ27375.1 .
RefSeqi YP_002309962.1. NC_011566.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 225849.swp_0551.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ27375 ; ACJ27375 ; swp_0551 .
GeneIDi 7031659.
KEGGi swp:swp_0551.
PATRICi 23539818. VBIShePie65056_0499.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SPIE225849:GH6V-535-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3."
    Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X.
    PLoS ONE 3:E1937-E1937(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WP3 / JCM 13877.

Entry informationi

Entry nameiFTHS_SHEPW
AccessioniPrimary (citable) accession number: B8CI99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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