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B8CI99 (FTHS_SHEPW) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:swp_0551
OrganismShewanella piezotolerans (strain WP3 / JCM 13877) [Complete proteome] [HAMAP]
Taxonomic identifier225849 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000196823

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B8CI99 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 602AA4ADA64F3C18

FASTA57060,198
        10         20         30         40         50         60 
MLSDINISRK HVCKPIAEIA TNLGIVESEL SVHGANKAKI SLSVTNRLAS KPDAKLVIVT 

        70         80         90        100        110        120 
AVTPTPYGEG KTVTTVGLTQ AMNAIGVKTC ACIRQPSMGP VFGIKGGAAG GGYAQVVPME 

       130        140        150        160        170        180 
ELNLHLTGDI HAVSSAHNLA AAAIDARLFH ETRLGAIAFT KESGLNAVNI DPENILWRRV 

       190        200        210        220        230        240 
VDHNERSLRQ IEVGFGAVNG PVHSSGFDIT KASELMAILA LSRDVKDLRQ RVGRLVLALD 

       250        260        270        280        290        300 
LVGKPITAED IGVAGAMTVI MRDAIEPTLM QTLSGDPCFI HAGPFANIAH GNSSIIADSI 

       310        320        330        340        350        360 
ASKLADVVVT EAGFGSDMGF EKFSNIKVRE SGYKPSAAVV VVTLRALKAN SGIESEVAID 

       370        380        390        400        410        420 
QPDMARLEAG FANLQWHINN VHQYGAPVVV AINRFPTDTS AELDWLQAKV ATTNAFGCAI 

       430        440        450        460        470        480 
SDAFANGAQG AAELAKVVHA ATMVESEFNC LYETTDTLES KLMTLAEVGY GAASVSLSDK 

       490        500        510        520        530        540 
AKLQLAWLHK QGYSELPVCI AKTPMSISHD PNVKGVPRNF ELPINELRLN AGAGFITALV 

       550        560        570 
GKVMTMPGLG IKPGYLNIDI DADDEIIGLA 

« Hide

References

[1]"Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3."
Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X.
PLoS ONE 3:E1937-E1937(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WP3 / JCM 13877.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000472 Genomic DNA. Translation: ACJ27375.1.
RefSeqYP_002309962.1. NC_011566.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING225849.swp_0551.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ27375; ACJ27375; swp_0551.
GeneID7031659.
KEGGswp:swp_0551.
PATRIC23539818. VBIShePie65056_0499.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13506.

Enzyme and pathway databases

BioCycSPIE225849:GH6V-535-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_SHEPW
AccessionPrimary (citable) accession number: B8CI99
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways