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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPIE225849:G1G7F-503-MONOMER
UniPathwayiUPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:swp_0551
OrganismiShewanella piezotolerans (strain WP3 / JCM 13877)
Taxonomic identifieri225849 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000000753 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001968231 – 570Formate--tetrahydrofolate ligaseAdd BLAST570

Proteomic databases

PRIDEiB8CI99

Interactioni

Protein-protein interaction databases

STRINGi225849.swp_0551

Structurei

3D structure databases

SMRiB8CI99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU Bacteria
COG2759 LUCA
HOGENOMiHOG000040280
KOiK01938
OMAiCGEIMTM
OrthoDBiPOG091H01S8

Family and domain databases

CDDicd00477 FTHFS, 1 hit
HAMAPiMF_01543 FTHFS, 1 hit
InterProiView protein in InterPro
IPR000559 Formate_THF_ligase
IPR020628 Formate_THF_ligase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01268 FTHFS, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00721 FTHFS_1, 1 hit
PS00722 FTHFS_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8CI99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSDINISRK HVCKPIAEIA TNLGIVESEL SVHGANKAKI SLSVTNRLAS
60 70 80 90 100
KPDAKLVIVT AVTPTPYGEG KTVTTVGLTQ AMNAIGVKTC ACIRQPSMGP
110 120 130 140 150
VFGIKGGAAG GGYAQVVPME ELNLHLTGDI HAVSSAHNLA AAAIDARLFH
160 170 180 190 200
ETRLGAIAFT KESGLNAVNI DPENILWRRV VDHNERSLRQ IEVGFGAVNG
210 220 230 240 250
PVHSSGFDIT KASELMAILA LSRDVKDLRQ RVGRLVLALD LVGKPITAED
260 270 280 290 300
IGVAGAMTVI MRDAIEPTLM QTLSGDPCFI HAGPFANIAH GNSSIIADSI
310 320 330 340 350
ASKLADVVVT EAGFGSDMGF EKFSNIKVRE SGYKPSAAVV VVTLRALKAN
360 370 380 390 400
SGIESEVAID QPDMARLEAG FANLQWHINN VHQYGAPVVV AINRFPTDTS
410 420 430 440 450
AELDWLQAKV ATTNAFGCAI SDAFANGAQG AAELAKVVHA ATMVESEFNC
460 470 480 490 500
LYETTDTLES KLMTLAEVGY GAASVSLSDK AKLQLAWLHK QGYSELPVCI
510 520 530 540 550
AKTPMSISHD PNVKGVPRNF ELPINELRLN AGAGFITALV GKVMTMPGLG
560 570
IKPGYLNIDI DADDEIIGLA
Length:570
Mass (Da):60,198
Last modified:March 3, 2009 - v1
Checksum:i602AA4ADA64F3C18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000472 Genomic DNA Translation: ACJ27375.1
RefSeqiWP_020910756.1, NC_011566.1

Genome annotation databases

EnsemblBacteriaiACJ27375; ACJ27375; swp_0551
KEGGiswp:swp_0551

Similar proteinsi

Entry informationi

Entry nameiFTHS_SHEPW
AccessioniPrimary (citable) accession number: B8CI99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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