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B8CH90 (B8CH90_SHEPW) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-ketoacyl-CoA thiolase HAMAP MF_01620
EC=2.3.1.16 HAMAP MF_01620
Alternative name(s):
Acetyl-CoA acyltransferase HAMAP MF_01620
Beta-ketothiolase HAMAP MF_01620
Fatty acid oxidation complex subunit beta HAMAP MF_01620
Gene names
Name:fadA HAMAP MF_01620
Ordered Locus Names:swp_0034
OrganismShewanella piezotolerans (strain WP3 / JCM 13877) [Complete proteome] [HAMAP] EMBL ACJ26882.1
Taxonomic identifier225849 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed By similarity. HAMAP MF_01620

Catalytic activity

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. HAMAP MF_01620 SAAS SAAS020613

Pathway

Lipid metabolism; fatty acid beta-oxidation. HAMAP MF_01620 SAAS SAAS020613

Subunit structure

Heterotetramer of two alpha chains (fadB) and two beta chains (fadA) By similarity. HAMAP MF_01620 SAAS SAAS020613

Subcellular location

Cytoplasm By similarity HAMAP MF_01620.

Sequence similarities

Belongs to the thiolase family. HAMAP MF_01620

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site911Acyl-thioester intermediate By similarity HAMAP MF_01620
Active site3431Proton acceptor By similarity HAMAP MF_01620
Active site3731Proton acceptor By similarity HAMAP MF_01620

Sequences

Sequence LengthMass (Da)Tools
B8CH90 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 04ED8EFA25D373A6

FASTA38740,875
        10         20         30         40         50         60 
MKNAVIVDCI RTPMGRSKAG VFRNVRAETL SAELMKSLLE RNPKLDPNTI EDVMWGCVQQ 

        70         80         90        100        110        120 
TLEQGFNIAR NAALLAGIPK QVGAVTVNRL CGSSMDALHQ AARAIMTGQG DTFIVGGVEH 

       130        140        150        160        170        180 
MGHVPMNHGV DFHPGLANNV AKASGMMGLT AEMLGKMHGI TREQQDAFAV RSHQRAHAAT 

       190        200        210        220        230        240 
VEGRFANEIV AIEGHDADGA LIKVEHDEVI RPETSMESLS GLRPAFDPAN GTVTAGTSSA 

       250        260        270        280        290        300 
LSDGASAMLV MEEEKAKELG LTIRARIRSM AIAGCDAAIM GYGPVPATQK ALKRAGLTVD 

       310        320        330        340        350        360 
DLDVIELNEA FAAQSLPCVK DLGLMDVVDE KINLNGGAIA LGHPLGCSGT RISTTLINLM 

       370        380 
EAKDAKYGLA TMCIGLGQGI ATIFERP

« Hide

References

[1]"Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3."
Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X.
PLoS ONE 3:E1937-E1937(2008) [PubMed: 18398463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: WP3 EMBL ACJ26882.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000472 Genomic DNA. Translation: ACJ26882.1.
RefSeqYP_002309469.1. NC_011566.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB8CH90.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7031167.
GenomeReviewsGene locus swp_0034 in contig CP000472_GR.
KEGGswp:swp_0034.
PATRIC23538864. VBIShePie65056_0034.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG370930.
OMASSMEAIH.
ProtClustDBPRK08947.

Family and domain databases

HAMAPMF_01620. FadA.
[Tree]
InterProIPR012805. FadA.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 4 hits.
KOK00632.
PANTHERPTHR18919:SF35. PTHR18919:SF35. 1 hit.
PTHR18919. Thiolase. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02445. FadA. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB8CH90_SHEPW
AccessionPrimary (citable) accession number: B8CH90
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info