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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

THAPSDRAFT_42475

Organism
Thalassiosira pseudonana (Marine diatom) (Cyclotella nana)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDH1), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (THAPSDRAFT_42475)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:THAPSDRAFT_42475Imported
OrganismiThalassiosira pseudonana (Marine diatom) (Cyclotella nana)Imported
Taxonomic identifieri35128 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesBacillariophytaCoscinodiscophyceaeThalassiosirophycidaeThalassiosiralesThalassiosiraceaeThalassiosira
Proteomesi
  • UP000001449 Componenti: Chromosome 14

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi35128.Thaps42475

Structurei

3D structure databases

ProteinModelPortaliB8CCT7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 447FAD_binding_2InterPro annotationAdd BLAST402
Domaini502 – 637Succ_DH_flav_CInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
HOGENOMiHOG000160475
InParanoidiB8CCT7
KOiK00234
OMAiGDSPWEH

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

B8CCT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSAFARRAS SKATKLASTA PTPTTAVRSL STSTTGDYTI VDHTYDALVI
60 70 80 90 100
GAGGSGLRAA MGLSEAGFKT ACVSKLFPTR SHTVAAQGGI NAALGNMGPD
110 120 130 140 150
DWRWHMYDTV KGSDWLGDQD AIHYMCREAP KAVLELEEFG LPFSRTEEGK
160 170 180 190 200
IYQRAFGGQS LDFGKGGQAH RCCAAADRTG HAMLHTLYGR SLAFDTTYFI
210 220 230 240 250
EYFAMDLLMT PDGQCVGAMA LNMEDGTLHR IKAKNTVLAT GGYGRTYFSC
260 270 280 290 300
TSAHTCTGDG NAMAMRAGLA NQDAEFVQFH PTGIYGAGCL ITEGCRGEGG
310 320 330 340 350
ILRNSEGERF MERYAPSAKD LASRDVVSRA MTMEIREGRG VGPKKDHCYL
360 370 380 390 400
HLDHLPAELL AERLPGISET AAIFAGVDVT KEPIPVLPTV HYNMGGIPTN
410 420 430 440 450
HLGEVIRTDF NADGSFNSDV VVPGLFAAGE AACASVHGAN RLGANSLLDI
460 470 480 490 500
VVFGRACANR IAEIAKPGDA IADAPADVGM DSVAELDKLR FATGSTPTSV
510 520 530 540 550
IRGEMQHLMQ DKAAVYRTEE LLAEGKKEID EVVQSFNDVH VTDKSLIWNT
560 570 580 590 600
DLVETLELRN LLGCAATTMH SAENRKESRG AHAHENYPDR LDDEWMKHTL
610 620 630
AYFDEKEGKT KIGYRPIHYY TLDEEECKTV PPVARVY
Length:637
Mass (Da):68,963
Last modified:March 3, 2009 - v1
Checksum:i3682775D4F77C653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000649 Genomic DNA Translation: EED89006.1
RefSeqiXP_002293997.1, XM_002293961.1

Genome annotation databases

EnsemblProtistsiEED89006; EED89006; THAPSDRAFT_42475
GeneIDi7441832
KEGGitps:THAPSDRAFT_42475

Similar proteinsi

Entry informationi

Entry nameiB8CCT7_THAPS
AccessioniPrimary (citable) accession number: B8CCT7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health