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Protein

Peroxisomal (S)-2-hydroxy-acid oxidase GLO1

Gene

GLO1

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Photorespiratory enzyme that can exert a strong regulation over photosynthesis, possibly through a feed-back inhibition on Rubisco activase. Not required for oxalate accumulation (By similarity).By similarity

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

FMNPROSITE-ProRule annotation

Pathwayi: photorespiration

This protein is involved in step 2 of the subpathway that synthesizes glycine from 2-phosphoglycolate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Peroxisomal (S)-2-hydroxy-acid oxidase GLO4 (GLO4), Peroxisomal (S)-2-hydroxy-acid oxidase GLO3 (GLO3), Peroxisomal (S)-2-hydroxy-acid oxidase GLO2 (GLO2), Peroxisomal (S)-2-hydroxy-acid oxidase GLO1 (GLO1), Peroxisomal (S)-2-hydroxy-acid oxidase GLO5 (GLO5)
  3. no protein annotated in this organism
This subpathway is part of the pathway photorespiration, which is itself part of Photosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycine from 2-phosphoglycolate, the pathway photorespiration and in Photosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25SubstratePROSITE-ProRule annotation1
Binding sitei107FMNPROSITE-ProRule annotation1
Binding sitei128FMNPROSITE-ProRule annotation1
Binding sitei130SubstratePROSITE-ProRule annotation1
Binding sitei156FMNPROSITE-ProRule annotation1
Binding sitei165SubstratePROSITE-ProRule annotation1
Binding sitei231FMNPROSITE-ProRule annotation1
Active sitei255Proton acceptorPROSITE-ProRule annotation1
Binding sitei258SubstratePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi286 – 310FMNPROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolate pathway, Host-virus interaction, Photorespiration
LigandFlavoprotein, FMN

Enzyme and pathway databases

ReactomeiR-OSA-389661 Glyoxylate metabolism and glycine degradation
R-OSA-390918 Peroxisomal lipid metabolism
UniPathwayiUPA00951; UER00912

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal (S)-2-hydroxy-acid oxidase GLO1 (EC:1.1.3.15)
Alternative name(s):
Glycolate oxidase 1
Short name:
GOX 1
Short name:
OsGLO1
Short chain alpha-hydroxy acid oxidase GLO1
Gene namesi
Name:GLO1
ORF Names:OsI_13800
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004034101 – 369Peroxisomal (S)-2-hydroxy-acid oxidase GLO1Add BLAST369

Proteomic databases

PRIDEiB8AKX6

Expressioni

Gene expression databases

ExpressionAtlasiB8AKX6 differential

Interactioni

Subunit structurei

Homotetramer or homooctamer. Interacts with rice dwarf virus (RDV) P8. This interaction promotes viral P8 relocation to virus factories peripheral to peroxisomes (By similarity).By similarity

Protein-protein interaction databases

STRINGi39946.BGIOSGA013686-PA

Structurei

3D structure databases

ProteinModelPortaliB8AKX6
SMRiB8AKX6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 360FMN hydroxy acid dehydrogenasePROSITE-ProRule annotationAdd BLAST360

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi367 – 369Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0538 Eukaryota
COG1304 LUCA
HOGENOMiHOG000217463
OMAiAVEYGMQ
OrthoDBiEOG09360EDE

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

B8AKX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEITNVMEY QAIAKQKLPK MIYDYYASGA EDEWTLKENR EAFSRILFRP
60 70 80 90 100
RILIDVSKID MSATVLGFKI SMPIMIAPSA MQKMAHPDGE YATARAASAA
110 120 130 140 150
GTIMTLSSWA TSSVEEVAST GPGIRFFQLY VYKDRNVVEQ LVRRAERAGF
160 170 180 190 200
KAIALTVDTP RLGRREADIK NRFVLPPYLT LKNFEGLDLA EMDKSNDSGL
210 220 230 240 250
ASYVAGQIDR TLSWKDVKWL QSITSLPILV KGVITAEDAR LAVHSGAAGI
260 270 280 290 300
IVSNHGARQL DYVPATISAL EEVVTAAAGR IPVYLDGGVR RGTDVFKALA
310 320 330 340 350
LGAAGVFIGR PVVFALAAEG EAGVRNVLRM MREEFELTMA LSGCTSLADI
360
TRAHIYTDAD RLARPFPRL
Length:369
Mass (Da):40,384
Last modified:March 3, 2009 - v1
Checksum:iB14AF6A0E95883FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000128 Genomic DNA Translation: EEC76290.1

Genome annotation databases

EnsemblPlantsiBGIOSGA013686-TA; BGIOSGA013686-PA; BGIOSGA013686
Os03t0786100-02; Os03t0786100-02; Os03g0786100
GrameneiBGIOSGA013686-TA; BGIOSGA013686-PA; BGIOSGA013686
Os03t0786100-02; Os03t0786100-02; Os03g0786100

Similar proteinsi

Entry informationi

Entry nameiGLO1_ORYSI
AccessioniPrimary (citable) accession number: B8AKX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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