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Protein

Inositol-tetrakisphosphate 1-kinase 2

Gene

ITPK2

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and participates in phytic acid biosynthesis in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.By similarity

Catalytic activityi

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.Curated
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.Curated
ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.Curated

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei481D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei901D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei125ATPBy similarity1
Binding sitei175ATPBy similarity1
Binding sitei1861D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei2181D-myo-inositol 1,3,4-trisphosphateBy similarity1
Binding sitei233ATPBy similarity1
Metal bindingi298Magnesium 1By similarity1
Metal bindingi313Magnesium 1By similarity1
Metal bindingi313Magnesium 2By similarity1
Metal bindingi315Magnesium 2By similarity1
Binding sitei3151D-myo-inositol 1,3,4-trisphosphateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 218ATPBy similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-tetrakisphosphate 1-kinase 2Curated (EC:2.7.1.134Curated)
Alternative name(s):
Inositol 1,3,4-trisphosphate 5/6-kinase 2Curated (EC:2.7.1.159Curated)
Short name:
Inositol-triphosphate 5/6-kinase 2Curated
Short name:
Ins(1,3,4)P(3) 5/6-kinase 2Curated
Short name:
OsITP5/6K-2Curated
Short name:
OsITPK2Curated
Gene namesi
Name:ITPK2
ORF Names:OsI_10626Imported
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000007015 Componenti: Chromosome 3

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004318721 – 349Inositol-tetrakisphosphate 1-kinase 2Add BLAST349

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi39946.BGIOSGA012174-PA.

Structurei

3D structure databases

SMRiB8AJL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ITPK1 family.Curated

Phylogenomic databases

eggNOGiENOG410IHA6. Eukaryota.
ENOG4110KIK. LUCA.
OMAiSHEXRES.
OrthoDBiEOG09360GWF.

Family and domain databases

InterProiView protein in InterPro
IPR008656. Inositol_tetrakis-P_1-kinase.
PANTHERiPTHR14217. PTHR14217. 1 hit.
PfamiView protein in Pfam
PF05770. Ins134_P3_kin. 1 hit.
PIRSFiPIRSF038186. ITPK. 1 hit.

Sequencei

Sequence statusi: Complete.

B8AJL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLHGEVSFD EDEEEVVMVP AAALSSSPLN GGAVPVTRLV VGYALTKKKV
60 70 80 90 100
KSFLQPNLLL LARKKGINLV AIDDTRPLAE QGPFDVILHK ITSKEWQQVL
110 120 130 140 150
EDYHEEHPEV TVLDPPNAIN HLNNRQSMLA EVSDLNLSSF YGEVCTPRQL
160 170 180 190 200
VIMRDPSSIP TAVAMAGLTL PLVAKPLVVD GTSKSHELSL AYDEASLSML
210 220 230 240 250
DPPLVLQEFV NHGGILFKVY IIGETIQVVR RFSLPDVNTY DLLNNVGVYR
260 270 280 290 300
FPRVSCAAAS ADHADLDPHI SELPPRPLLE KLGKELRGRL GLRLFNIDMI
310 320 330 340
RELGTKDRYY IIDINYFPGF GKMPGYEHIF TDFLLNLAQS KYKKCLSGG
Length:349
Mass (Da):38,800
Last modified:March 3, 2009 - v1
Checksum:i6759CDB676A83E67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000128 Genomic DNA. Translation: EEC74810.1.

Genome annotation databases

EnsemblPlantsiBGIOSGA012174-TA; BGIOSGA012174-PA; BGIOSGA012174.
OS03T0230500-01; OS03T0230500-01; OS03G0230500.
GrameneiBGIOSGA012174-TA; BGIOSGA012174-PA; BGIOSGA012174.
OS03T0230500-01; OS03T0230500-01; OS03G0230500.

Similar proteinsi

Entry informationi

Entry nameiITPK2_ORYSI
AccessioniPrimary (citable) accession number: B8AJL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: March 3, 2009
Last modified: November 22, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families