B8A689 (B8A689_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Toll-like receptor 4a EMBL CAX12071.1

Submitted name:
Toll-like receptor 4b, duplicate a Ensembl ENSDARP00000104680

Gene names

Name:	tlr4ba Ensembl ENSDARP00000104680 ZFIN ZDB-GENE-040219-8
Synonyms:	tlr4a EMBL CAX12071.1 ZFIN ZDB-GENE-040219-8
ORF Names:	CH211-198A12.1-001 EMBL CAX12071.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL CAX12071.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	787 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Sequence similarities

Contains 1 TIR domain. SAAS SAAS000157

Ontologies

Keywords
Cellular component	Membrane
Domain	Leucine-rich repeat SAAS SAAS000157 Repeat SAAS SAAS000157 Transmembrane Transmembrane helix SAAS SAAS000483
Molecular function	Receptor EMBL CAX12071.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8A689 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 8B9823E7E5F174AD	FASTA	787	90,613
	10 20 30 40 50 60 MGRNLSSIPS SIPSSVQTLD FSFNFFPQLK KTIFPVLSFL RVLDLSRCHI RQIENDAFYN 70 80 90 100 110 120 VKNLTTLFLT GNPIIYFAPG CLNTLYNLQR LVLVDIGLES LQLNINNLTK LQELNVGTNY 130 140 150 160 170 180 IQSMTLPPFM TTFKNFSLLD LHANNISIIR TNHTVVLREI GRNMTLILTW NPLLHIEPGA 190 200 210 220 230 240 FKDVYLRQLD IRSAFVSFSA QKAALKALHG LNVKRLIFGK YREDNGFHFV DNDVLDGLCC 250 260 270 280 290 300 FNFQEVSYYV LESAKTTIAI FRCMINATRI TVKGGNIYEM ETVHFHKTKE LYLINNGLGT 310 320 330 340 350 360 LPTKQLSHLH TLEKLEITHN SEPIFAEPFT DLPKLQYVDL SDNQLKIKHC CSTLLSGTPQ 370 380 390 400 410 420 INYLNLSLNS EISVDVGGFE GLDSLEILDF SYTRVVRIGY LSVLSNLKNL RYLDVSYSSV 430 440 450 460 470 480 TFSNIFCFLG LSSLNVLKMA GNNFQGNVAK YVFNNLTLLE HLDMSFCHLV ELHTSSFKYL 490 500 510 520 530 540 QRLRHLNVKG NYLIKIDFLT HPNLKQLTSF YVEKNSITAI PLHVLKNLPM NLSEFDLSFN 550 560 570 580 590 600 PIDCSCSQTD FMLWIINNQK VLKQPENILC KTISPNSDFR VTDFDIDHCV YKKKLIIVLP 610 620 630 640 650 660 VFCVVFIVVL SILVYRFQFY LRYCWILLRG YRSPGQQECS YDAFVIFSSY DEAWVMNELM 670 680 690 700 710 720 ENLENGVPPI QLCLHMRDFQ AGKSIASNII DEGIMGSRKI IVVVSQHFID SAWCRFEFEL 730 740 750 760 770 780 AQSRFLMERN ANIIIIILED VAERKTKKIL GLHKHLKKNT YLKWSRDPLS NMRFWIRLRK AIVATKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Corby N. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000104680.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000104680.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX908770 Genomic DNA. Translation: CAX12071.1.
IPI	IPI00832979.
UniGene	Dr.89708.
3D structure databases
ProteinModelPortal	B8A689.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000124036; ENSDARP00000104680; ENSDARG00000019742.
Organism-specific databases
ZFIN	ZDB-GENE-040219-8. tlr4ba.
Phylogenomic databases
HOVERGEN	HBG018823.
Gene expression databases
Bgee	B8A689.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000157. TIR_dom. [Graphical view]
Pfam	PF00560. LRR_1. 2 hits. PF01582. TIR. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 1 hit. SM00082. LRRCT. 1 hit. SM00255. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS51450. LRR. 11 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8A689_DANRE

Accession

Primary (citable) accession number: B8A689

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)