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B8A5H6

- B8A5H6_DANRE

UniProt

B8A5H6 - B8A5H6_DANRE

Protein
Submitted name:

Uncharacterized protein

Gene

hkdc1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fructokinase activity Source: RefGenome
    3. glucokinase activity Source: RefGenome
    4. mannokinase activity Source: RefGenome

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. cellular glucose homeostasis Source: RefGenome
    3. glucose 6-phosphate metabolic process Source: GOC
    4. glycolytic process Source: RefGenome

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:hkdc1Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 13

    Organism-specific databases

    ZFINiZDB-GENE-030131-9801. hkdc1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RefGenome

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000056522.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the hexokinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG5026.
    GeneTreeiENSGT00390000017159.
    HOGENOMiHOG000162671.
    HOVERGENiHBG005020.
    KOiK00844.
    OMAiVKMLPTH.
    OrthoDBiEOG7S21X5.
    PhylomeDBiB8A5H6.
    TreeFamiTF314238.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 2 hits.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8A5H6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFAVHLLSFY FSKLQEDQIK KVDRFLYAMR LSEDQLKDIS ARFRLEMEKG    50
    LSSESNAAAA VKMLPTHVYS TPDGSEKGEF LALDLGGSKF KVLQVKVSED 100
    GKGKVEMESE TFPIPEEIVN GRGTELFEHV AESLKSFLQK HHINHTRKPL 150
    GFTFSFPCAQ SKIDEGVLLS WSKNFKVRGV QGTNVVQSLR KAIRKVGDLD 200
    VDVLAMVNDT VGAMMTCGYD DQNCEVGVIV GTGTNACYME EMRHIDLVEG 250
    DEGRMCINTE LGAFGDDGVL DDFITSFDRE IDAASINPGK QLFEKMVSGM 300
    YMGELVRLIL LRMAKKGLLF RGQISDALRT KGTFHTNHMC LIEQYKSGLE 350
    NTKEILEDLG LNPSDDDCIA VQHVCTIVSF RSANLVAAAL AAILTRIREN 400
    KKLKTLRTTV GVDGTVYRTH PQYPKRLHKV VRHLVPDCHV RFVLSESGSA 450
    KGAAMVTAVA QRLASQRKEI DDTLAAFALT STQLQEVKQK MHVELERGLK 500
    KETHPTASVK MLPTYVYRTP DGTERGKYLA LDLGGTNFRV LVVKIRTGMR 550
    NSVRMYNKIY AIPLEIMQGT GEELFDHIVQ CISDFLDYMG MKNTRLPLGF 600
    TFSFPCNQTG IDKGDLVCWT KGFKATDCEG YDVVDMLREA IKRRNEFDLD 650
    IVAIVNDTVG TMMTCAYEDP KCQIGLIAGT GSNVCYMEEM KNIEIVEGDE 700
    GQMCVNTEWG GFGENDNIED IRTRYDREVD SGSLNAGKQR FEKMTSGMYL 750
    GEIVRQILID LTKRGFLFRG RITERLKTKG IFETKFLSQI ESDRLALLQV 800
    RCILQSLGLD STCDDSIIVK EVCGAVSRRA AQLCGAGMAA IVDKIRENRG 850
    LDRLDITVGV DGTLYKLHPH FSTILKETVR ELAPNCKVDF ILSEDGSGKG 900
    AALITAVARQ HHVQKQEQN 919
    Length:919
    Mass (Da):102,548
    Last modified:March 3, 2009 - v1
    Checksum:iE06A9CAC14BF6FDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX546482 Genomic DNA. No translation available.
    RefSeqiNP_001108597.1. NM_001115125.1.
    UniGeneiDr.34012.

    Genome annotation databases

    EnsembliENSDART00000056523; ENSDARP00000056522; ENSDARG00000038703.
    GeneIDi321224.
    KEGGidre:321224.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX546482 Genomic DNA. No translation available.
    RefSeqi NP_001108597.1. NM_001115125.1.
    UniGenei Dr.34012.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000056522.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000056523 ; ENSDARP00000056522 ; ENSDARG00000038703 .
    GeneIDi 321224.
    KEGGi dre:321224.

    Organism-specific databases

    CTDi 80201.
    ZFINi ZDB-GENE-030131-9801. hkdc1.

    Phylogenomic databases

    eggNOGi COG5026.
    GeneTreei ENSGT00390000017159.
    HOGENOMi HOG000162671.
    HOVERGENi HBG005020.
    KOi K00844.
    OMAi VKMLPTH.
    OrthoDBi EOG7S21X5.
    PhylomeDBi B8A5H6.
    TreeFami TF314238.

    Miscellaneous databases

    NextBioi 20807291.
    PROi B8A5H6.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 2 hits.
    PF03727. Hexokinase_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TuebingenImported.
    2. Ensembl
      Submitted (AUG-2013) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: TuebingenImported.

    Entry informationi

    Entry nameiB8A5H6_DANRE
    AccessioniPrimary (citable) accession number: B8A5H6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3