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B8A5H6

- B8A5H6_DANRE

UniProt

B8A5H6 - B8A5H6_DANRE

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Protein
Submitted name:

Uncharacterized protein

Gene

hkdc1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: RefGenome
  3. glucokinase activity Source: RefGenome
  4. mannokinase activity Source: RefGenome

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. cellular glucose homeostasis Source: RefGenome
  3. glucose 6-phosphate metabolic process Source: GOC
  4. glycolytic process Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:hkdc1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-030131-9801. hkdc1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: RefGenome
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000056522.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
GeneTreeiENSGT00390000017159.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
InParanoidiB8A5H6.
KOiK00844.
OMAiVKMLPTH.
OrthoDBiEOG7S21X5.
PhylomeDBiB8A5H6.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8A5H6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFAVHLLSFY FSKLQEDQIK KVDRFLYAMR LSEDQLKDIS ARFRLEMEKG
60 70 80 90 100
LSSESNAAAA VKMLPTHVYS TPDGSEKGEF LALDLGGSKF KVLQVKVSED
110 120 130 140 150
GKGKVEMESE TFPIPEEIVN GRGTELFEHV AESLKSFLQK HHINHTRKPL
160 170 180 190 200
GFTFSFPCAQ SKIDEGVLLS WSKNFKVRGV QGTNVVQSLR KAIRKVGDLD
210 220 230 240 250
VDVLAMVNDT VGAMMTCGYD DQNCEVGVIV GTGTNACYME EMRHIDLVEG
260 270 280 290 300
DEGRMCINTE LGAFGDDGVL DDFITSFDRE IDAASINPGK QLFEKMVSGM
310 320 330 340 350
YMGELVRLIL LRMAKKGLLF RGQISDALRT KGTFHTNHMC LIEQYKSGLE
360 370 380 390 400
NTKEILEDLG LNPSDDDCIA VQHVCTIVSF RSANLVAAAL AAILTRIREN
410 420 430 440 450
KKLKTLRTTV GVDGTVYRTH PQYPKRLHKV VRHLVPDCHV RFVLSESGSA
460 470 480 490 500
KGAAMVTAVA QRLASQRKEI DDTLAAFALT STQLQEVKQK MHVELERGLK
510 520 530 540 550
KETHPTASVK MLPTYVYRTP DGTERGKYLA LDLGGTNFRV LVVKIRTGMR
560 570 580 590 600
NSVRMYNKIY AIPLEIMQGT GEELFDHIVQ CISDFLDYMG MKNTRLPLGF
610 620 630 640 650
TFSFPCNQTG IDKGDLVCWT KGFKATDCEG YDVVDMLREA IKRRNEFDLD
660 670 680 690 700
IVAIVNDTVG TMMTCAYEDP KCQIGLIAGT GSNVCYMEEM KNIEIVEGDE
710 720 730 740 750
GQMCVNTEWG GFGENDNIED IRTRYDREVD SGSLNAGKQR FEKMTSGMYL
760 770 780 790 800
GEIVRQILID LTKRGFLFRG RITERLKTKG IFETKFLSQI ESDRLALLQV
810 820 830 840 850
RCILQSLGLD STCDDSIIVK EVCGAVSRRA AQLCGAGMAA IVDKIRENRG
860 870 880 890 900
LDRLDITVGV DGTLYKLHPH FSTILKETVR ELAPNCKVDF ILSEDGSGKG
910
AALITAVARQ HHVQKQEQN
Length:919
Mass (Da):102,548
Last modified:March 3, 2009 - v1
Checksum:iE06A9CAC14BF6FDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX546482 Genomic DNA. No translation available.
RefSeqiNP_001108597.1. NM_001115125.1.
UniGeneiDr.34012.

Genome annotation databases

EnsembliENSDART00000056523; ENSDARP00000056522; ENSDARG00000038703.
GeneIDi321224.
KEGGidre:321224.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX546482 Genomic DNA. No translation available.
RefSeqi NP_001108597.1. NM_001115125.1.
UniGenei Dr.34012.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000056522.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000056523 ; ENSDARP00000056522 ; ENSDARG00000038703 .
GeneIDi 321224.
KEGGi dre:321224.

Organism-specific databases

CTDi 80201.
ZFINi ZDB-GENE-030131-9801. hkdc1.

Phylogenomic databases

eggNOGi COG5026.
GeneTreei ENSGT00390000017159.
HOGENOMi HOG000162671.
HOVERGENi HBG005020.
InParanoidi B8A5H6.
KOi K00844.
OMAi VKMLPTH.
OrthoDBi EOG7S21X5.
PhylomeDBi B8A5H6.
TreeFami TF314238.

Miscellaneous databases

NextBioi 20807291.
PROi B8A5H6.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  2. Ensembl
    Submitted (AUG-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiB8A5H6_DANRE
AccessioniPrimary (citable) accession number: B8A5H6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3