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Protein

Fibroblast growth factor receptor

Gene

Fgfr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei557Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95523. Fgfr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei306 – 328HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiB7ZWP2.
PaxDbiB7ZWP2.

Structurei

3D structure databases

ProteinModelPortaliB7ZWP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 177Ig-likeInterPro annotationAdd BLAST94
Domaini186 – 286Ig-likeInterPro annotationAdd BLAST101
Domaini412 – 701Protein kinaseInterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000263410.
HOVERGENiHBG000345.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PANTHERiPTHR24416:SF468. PTHR24416:SF468. 1 hit.
PfamiView protein in Pfam
PF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Complete.

B7ZWP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT
60 70 80 90 100
TLEPEDAISS GDDEDDTDSS EDVVSENRSN QRAPYWTNTE KMEKRLHAVP
110 120 130 140 150
AANTVKFRCP AGGNPTPTMR WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES
160 170 180 190 200
VVPSDKGNYT CLVENEYGSI NHTYHLDVVE RSPHRPILQA GLPANASTVV
210 220 230 240 250
GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK YGPDGLPYLK VLKHSGINSS
260 270 280 290 300
NAEVLALFNV TEMDAGEYIC KVSNYIGQAN QSAWLTVLPK QQAPVREKEI
310 320 330 340 350
TASPDYLEIA IYCIGVFLIA CMVVTVIFCR MKTTTKKPDF SSQPAVHKLT
360 370 380 390 400
KRIPLRRQVT VSAESSSSMN SNTPLVRITT RLSSTADTPM LAGVSEYELP
410 420 430 440 450
EDPKWEFPRD KLTLGKPLGE GCFGQVVMAE AVGIDKDKPK EAVTVAVKML
460 470 480 490 500
KDDATEKDLS DLVSEMEMMK MIGKHKNIIN LLGACTQDGP LYVIVEYASK
510 520 530 540 550
GNLREYLRAR RPPGMEYSYD INRVPEEQMT FKDLVSCTYQ LARGMEYLAS
560 570 580 590 600
QKCIHRDLAA RNVLVTENNV MKIADFGLAR DINNIDYYKK TTNGRLPVKW
610 620 630 640 650
MAPEALFDRV YTHQSDVWSF GVLMWEIFTL GGSPYPGIPV EELFKLLKEG
660 670 680 690 700
HRMDKPTNCT NELYMMMRDC WHAVPSQRPT FKQLVEDLDR ILTLTTNEEY
710 720 730 740 750
LDLTQPLEQY SPSYPDTRSS CSSGDDSVFS PDPMPYEPCL PQYPHINGSV

KT
Length:752
Mass (Da):84,511
Last modified:March 3, 2009 - v1
Checksum:i9E260F6D9D7BF1BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC172174 mRNA. Translation: AAI72174.1.
RefSeqiXP_006507417.1. XM_006507354.3.
UniGeneiMm.16340.

Genome annotation databases

GeneIDi14183.
UCSCiuc012fuw.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiB7ZWP2_MOUSE
AccessioniPrimary (citable) accession number: B7ZWP2
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 27, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)