Fibroblast growth factor receptor - Mus musculus (Mouse)

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B7ZWP2 (B7ZWP2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 51. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Fibroblast growth factor receptor PIRNR PIRNR000628
EC=2.7.10.1 PIRNR PIRNR000628

Gene names

Name:

Fgfr2 EMBL AAI72174.1 MGI 95523

Organism

Mus musculus (Mouse) EMBL AAI72174.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	752 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. PIRNR PIRNR000628 SAAS SAAS008266

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. PIRNR PIRNR000628

Contains protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain SAAS SAAS008266 Repeat SAAS SAAS008266 Transmembrane Transmembrane helix SAAS SAAS008266
Ligand	ATP-binding PIRNR PIRNR000628 SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Receptor PIRNR PIRNR000628 SAAS SAAS008266 Transferase Tyrosine-protein kinase PIRNR PIRNR000628 SAAS SAAS008266
PTM	Phosphoprotein SAAS SAAS008266
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from genetic interaction PubMed 16778080. Source: MGI axonogenesis Inferred from mutant phenotype PubMed 17951031. Source: MGI bone mineralization Inferred from mutant phenotype PubMed 12756187. Source: MGI branch elongation involved in salivary gland morphogenesis Inferred from mutant phenotype PubMed 15972105. Source: MGI branching involved in labyrinthine layer morphogenesis Inferred from mutant phenotype PubMed 9435295. Source: MGI branching morphogenesis of a nerve Inferred from mutant phenotype PubMed 17951031. Source: MGI bud elongation involved in lung branching Inferred from mutant phenotype PubMed 16989802. Source: MGI cell fate commitment Inferred from direct assay PubMed 15509736. Source: MGI coronal suture morphogenesis Inferred from mutant phenotype PubMed 19389359. Source: MGI embryonic cranial skeleton morphogenesis Inferred from electronic annotation. Source: InterPro embryonic digestive tract morphogenesis Inferred from mutant phenotype PubMed 16618415 PubMed 21550054. Source: MGI embryonic pattern specification Inferred from mutant phenotype PubMed 16618415. Source: MGI endodermal digestive tract morphogenesis Inferred from mutant phenotype PubMed 21550054. Source: MGI epithelial cell proliferation involved in salivary gland morphogenesis Inferred from mutant phenotype PubMed 15972105. Source: MGI fibroblast growth factor receptor signaling pathway involved in mammary gland specification Inferred from mutant phenotype PubMed 16720875. Source: MGI hair follicle morphogenesis Inferred from mutant phenotype PubMed 14530295. Source: MGI lacrimal gland development Inferred from mutant phenotype PubMed 10821755. Source: MGI lateral sprouting from an epithelium Inferred from mutant phenotype PubMed 12666202. Source: MGI lens fiber cell development Inferred from mutant phenotype PubMed 23136392. Source: MGI limb bud formation Inferred from mutant phenotype PubMed 10518547 PubMed 9435295. Source: MGI lung alveolus development Inferred from mutant phenotype PubMed 16989802. Source: MGI lung lobe morphogenesis Inferred from mutant phenotype PubMed 16989802. Source: MGI lung-associated mesenchyme development Inferred from mutant phenotype PubMed 16989802. Source: MGI mammary gland bud formation Inferred from mutant phenotype PubMed 11782400. Source: MGI membranous septum morphogenesis Inferred from mutant phenotype PubMed 16687131. Source: MGI mesenchymal cell differentiation involved in lung development Inferred from genetic interaction PubMed 16989802. Source: MGI mesenchymal cell proliferation involved in lung development Inferred from mutant phenotype PubMed 16989802. Source: MGI midbrain development Inferred from genetic interaction PubMed 17687036. Source: MGI multicellular organism growth Inferred from mutant phenotype PubMed 16989802. Source: MGI negative regulation of cell proliferation Inferred from genetic interaction PubMed 18455718. Source: MGI negative regulation of mitosis Inferred from genetic interaction PubMed 18455718. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 16989802. Source: MGI neuromuscular junction development Inferred from mutant phenotype PubMed 17418794. Source: MGI odontogenesis Inferred from mutant phenotype PubMed 17951031. Source: MGI organ growth Inferred from mutant phenotype PubMed 16618415. Source: MGI otic vesicle formation Inferred from mutant phenotype PubMed 9435295. Source: MGI outflow tract septum morphogenesis Inferred from mutant phenotype PubMed 16687131. Source: MGI positive regulation of ERK1 and ERK2 cascade Inferred from genetic interaction PubMed 17202188. Source: MGI positive regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 16720875. Source: MGI positive regulation of cardiac muscle cell proliferation Inferred from genetic interaction PubMed 15621532. Source: MGI positive regulation of cell division Inferred from mutant phenotype PubMed 14530295. Source: MGI positive regulation of epithelial cell proliferation involved in lung morphogenesis Inferred from mutant phenotype PubMed 16989802. Source: MGI positive regulation of mesenchymal cell proliferation Inferred from genetic interaction PubMed 16540513. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 16989802. Source: MGI post-embryonic development Inferred from mutant phenotype PubMed 16989802. Source: MGI prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Inferred from mutant phenotype PubMed 17215304. Source: MGI prostate epithelial cord elongation Inferred from mutant phenotype PubMed 17215304. Source: MGI regulation of branching involved in prostate gland morphogenesis Inferred from mutant phenotype PubMed 17202188. Source: MGI regulation of cell fate commitment Inferred from mutant phenotype PubMed 16989802. Source: MGI regulation of fibroblast growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 16989802. Source: MGI regulation of multicellular organism growth Inferred from mutant phenotype PubMed 9435295. Source: MGI regulation of smooth muscle cell differentiation Inferred from mutant phenotype PubMed 16989802. Source: MGI regulation of smoothened signaling pathway Inferred from mutant phenotype PubMed 16618415. Source: MGI squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Inferred from mutant phenotype PubMed 17215304. Source: MGI synaptic vesicle transport Inferred from mutant phenotype PubMed 17418794. Source: MGI ureteric bud development Inferred from genetic interaction PubMed 16442091. Source: MGI ventricular cardiac muscle tissue morphogenesis Inferred from mutant phenotype PubMed 16687131. Source: MGI
Cellular_component	extracellular region Traceable author statement PubMed 12024206. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay PubMed 15229180 PubMed 15944199. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW fibroblast growth factor binding Inferred from direct assay PubMed 9435295. Source: MGI fibroblast growth factor-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Active site

557

Proton acceptor By similarity PIRSR PIRSR000628-1

Sequences

Sequence

Length

Mass (Da)

Tools

B7ZWP2 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 9E260F6D9D7BF1BE
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FASTA

752

84,511

        10         20         30         40         50         60 
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT TLEPEDAISS 

        70         80         90        100        110        120 
GDDEDDTDSS EDVVSENRSN QRAPYWTNTE KMEKRLHAVP AANTVKFRCP AGGNPTPTMR 

       130        140        150        160        170        180 
WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CLVENEYGSI NHTYHLDVVE 

       190        200        210        220        230        240 
RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK YGPDGLPYLK 

       250        260        270        280        290        300 
VLKHSGINSS NAEVLALFNV TEMDAGEYIC KVSNYIGQAN QSAWLTVLPK QQAPVREKEI 

       310        320        330        340        350        360 
TASPDYLEIA IYCIGVFLIA CMVVTVIFCR MKTTTKKPDF SSQPAVHKLT KRIPLRRQVT 

       370        380        390        400        410        420 
VSAESSSSMN SNTPLVRITT RLSSTADTPM LAGVSEYELP EDPKWEFPRD KLTLGKPLGE 

       430        440        450        460        470        480 
GCFGQVVMAE AVGIDKDKPK EAVTVAVKML KDDATEKDLS DLVSEMEMMK MIGKHKNIIN 

       490        500        510        520        530        540 
LLGACTQDGP LYVIVEYASK GNLREYLRAR RPPGMEYSYD INRVPEEQMT FKDLVSCTYQ 

       550        560        570        580        590        600 
LARGMEYLAS QKCIHRDLAA RNVLVTENNV MKIADFGLAR DINNIDYYKK TTNGRLPVKW 

       610        620        630        640        650        660 
MAPEALFDRV YTHQSDVWSF GVLMWEIFTL GGSPYPGIPV EELFKLLKEG HRMDKPTNCT 

       670        680        690        700        710        720 
NELYMMMRDC WHAVPSQRPT FKQLVEDLDR ILTLTTNEEY LDLTQPLEQY SPSYPDTRSS 

       730        740        750 
CSSGDDSVFS PDPMPYEPCL PQYPHINGSV KT

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References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.

Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain EMBL AAI72174.1.

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC172174 mRNA. Translation: AAI72174.1.
IPI	IPI00844785.
UniGene	Mm.16340.
3D structure databases
ProteinModelPortal	B7ZWP2.
SMR	B7ZWP2. Positions 81-291, 398-696.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:95523. Fgfr2.
Phylogenomic databases
HOGENOM	HOG000263410.
HOVERGEN	HBG000345.
Gene expression databases
ArrayExpress	B7ZWP2.
Bgee	B7ZWP2.
Genevestigator	B7ZWP2.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR028175. FGF_rcpt_2. IPR016248. FGF_rcpt_fam. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
PANTHER	PTHR24416:SF130. PTHR24416:SF130. 1 hit.
Pfam	PF07679. I-set. 2 hits. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PIRSF	PIRSF000628. FGFR. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00408. IGc2. 2 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. SSF56112. 1 hit.
PROSITE	PS50835. IG_LIKE. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FGFR2. mouse.
NextBio	35547779.
SOURCE	Search...

Entry information

Entry name

B7ZWP2_MOUSE

Accession

Primary (citable) accession number: B7ZWP2

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	November 13, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information