UniProtKB - B7ZWP2 (B7ZWP2_MOUSE)
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Protein
Fibroblast growth factor receptor
Gene
Fgfr2
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 557 | Proton acceptorUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- fibroblast growth factor-activated receptor activity Source: InterPro
GO - Biological processi
- positive regulation of cell proliferation Source: InterPro
Keywordsi
Molecular function | Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation |
Ligand | ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation) |
Gene namesi | Name:Fgfr2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:95523. Fgfr2. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 20 – 40 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 306 – 328 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 84 – 177 | Ig-likeInterPro annotationAdd BLAST | 94 | |
Domaini | 186 – 286 | Ig-likeInterPro annotationAdd BLAST | 101 | |
Domaini | 412 – 701 | Protein kinaseInterPro annotationAdd BLAST | 290 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation
Keywords - Domaini
Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotationPhylogenomic databases
eggNOGi | KOG0200. Eukaryota. COG0515. LUCA. |
HOGENOMi | HOG000263410. |
HOVERGENi | HBG000345. |
Family and domain databases
Gene3Di | 2.60.40.10. 2 hits. |
InterProi | View protein in InterPro IPR016248. FGF_rcpt_fam. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. |
Pfami | View protein in Pfam PF07679. I-set. 2 hits. PF07714. Pkinase_Tyr. 1 hit. |
PIRSFi | PIRSF000628. FGFR. 1 hit. |
PRINTSi | PR00109. TYRKINASE. |
SMARTi | View protein in SMART SM00409. IG. 2 hits. SM00408. IGc2. 2 hits. SM00219. TyrKc. 1 hit. |
SUPFAMi | SSF48726. SSF48726. 2 hits. SSF56112. SSF56112. 1 hit. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. |
i Sequence
Sequence statusi: Complete.
B7ZWP2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT
60 70 80 90 100
TLEPEDAISS GDDEDDTDSS EDVVSENRSN QRAPYWTNTE KMEKRLHAVP
110 120 130 140 150
AANTVKFRCP AGGNPTPTMR WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES
160 170 180 190 200
VVPSDKGNYT CLVENEYGSI NHTYHLDVVE RSPHRPILQA GLPANASTVV
210 220 230 240 250
GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK YGPDGLPYLK VLKHSGINSS
260 270 280 290 300
NAEVLALFNV TEMDAGEYIC KVSNYIGQAN QSAWLTVLPK QQAPVREKEI
310 320 330 340 350
TASPDYLEIA IYCIGVFLIA CMVVTVIFCR MKTTTKKPDF SSQPAVHKLT
360 370 380 390 400
KRIPLRRQVT VSAESSSSMN SNTPLVRITT RLSSTADTPM LAGVSEYELP
410 420 430 440 450
EDPKWEFPRD KLTLGKPLGE GCFGQVVMAE AVGIDKDKPK EAVTVAVKML
460 470 480 490 500
KDDATEKDLS DLVSEMEMMK MIGKHKNIIN LLGACTQDGP LYVIVEYASK
510 520 530 540 550
GNLREYLRAR RPPGMEYSYD INRVPEEQMT FKDLVSCTYQ LARGMEYLAS
560 570 580 590 600
QKCIHRDLAA RNVLVTENNV MKIADFGLAR DINNIDYYKK TTNGRLPVKW
610 620 630 640 650
MAPEALFDRV YTHQSDVWSF GVLMWEIFTL GGSPYPGIPV EELFKLLKEG
660 670 680 690 700
HRMDKPTNCT NELYMMMRDC WHAVPSQRPT FKQLVEDLDR ILTLTTNEEY
710 720 730 740 750
LDLTQPLEQY SPSYPDTRSS CSSGDDSVFS PDPMPYEPCL PQYPHINGSV
KT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC172174 mRNA. Translation: AAI72174.1. |
RefSeqi | XP_006507417.1. XM_006507354.3. |
UniGenei | Mm.16340. |
Genome annotation databases
GeneIDi | 14183. |
UCSCi | uc012fuw.1. mouse. |
Similar proteinsi
Entry informationi
Entry namei | B7ZWP2_MOUSE | |
Accessioni | B7ZWP2Primary (citable) accession number: B7ZWP2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 3, 2009 |
Last sequence update: | March 3, 2009 | |
Last modified: | February 28, 2018 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |