Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B7ZWP2 (B7ZWP2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor receptor PIRNR PIRNR000628

EC=2.7.10.1 PIRNR PIRNR000628
Gene names
Name:Fgfr2 EMBL AAI72174.1 MGI 95523
OrganismMus musculus (Mouse) EMBL AAI72174.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length752 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. PIRNR PIRNR000628 SAAS SAAS013098

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. PIRNR PIRNR000628

Contains protein kinase domain. SAAS SAAS013098

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain SAAS SAAS020635
Repeat SAAS SAAS013098
Transmembrane
Transmembrane helix SAAS SAAS013098
   LigandATP-binding PIRNR PIRNR000628 SAAS SAAS013098
Nucleotide-binding
   Molecular functionKinase
Receptor PIRNR PIRNR000628 SAAS SAAS013098
Transferase
Tyrosine-protein kinase PIRNR PIRNR000628 SAAS SAAS013098
   PTMPhosphoprotein SAAS SAAS020635
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from genetic interaction PubMed 16778080. Source: MGI

axonogenesis

Inferred from mutant phenotype PubMed 17951031. Source: MGI

bone development

Inferred from mutant phenotype PubMed 16989802. Source: MGI

bone mineralization

Inferred from mutant phenotype PubMed 12756187. Source: MGI

bone morphogenesis

Inferred from mutant phenotype PubMed 10518547. Source: MGI

branch elongation involved in salivary gland morphogenesis

Inferred from mutant phenotype PubMed 15972105. Source: MGI

branching involved in labyrinthine layer morphogenesis

Inferred from mutant phenotype PubMed 9435295. Source: MGI

branching involved in prostate gland morphogenesis

Inferred from mutant phenotype PubMed 12666202PubMed 17215304. Source: MGI

branching involved in salivary gland morphogenesis

Inferred from mutant phenotype PubMed 11731698. Source: MGI

branching morphogenesis of a nerve

Inferred from mutant phenotype PubMed 17951031. Source: MGI

bud elongation involved in lung branching

Inferred from mutant phenotype PubMed 16989802. Source: MGI

cell fate commitment

Inferred from direct assay PubMed 15509736. Source: MGI

cell-cell signaling

Inferred from mutant phenotype PubMed 15199404. Source: MGI

coronal suture morphogenesis

Inferred from mutant phenotype PubMed 19389359. Source: MGI

digestive tract development

Inferred from mutant phenotype PubMed 15234214. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from electronic annotation. Source: InterPro

embryonic digestive tract morphogenesis

Inferred from mutant phenotype PubMed 16618415PubMed 21550054. Source: MGI

embryonic organ development

Inferred from mutant phenotype PubMed 9435295. Source: MGI

embryonic organ morphogenesis

Inferred from mutant phenotype PubMed 15843416. Source: MGI

embryonic pattern specification

Inferred from mutant phenotype PubMed 16618415. Source: MGI

endodermal digestive tract morphogenesis

Inferred from mutant phenotype PubMed 21550054. Source: MGI

epidermis morphogenesis

Inferred from mutant phenotype PubMed 14530295. Source: MGI

epithelial cell differentiation

Inferred from mutant phenotype PubMed 16618415. Source: MGI

epithelial cell proliferation

Inferred from mutant phenotype PubMed 11312155PubMed 15843416. Source: MGI

epithelial cell proliferation involved in salivary gland morphogenesis

Inferred from mutant phenotype PubMed 15972105. Source: MGI

epithelial tube branching involved in lung morphogenesis

Inferred from mutant phenotype PubMed 24058167. Source: MGI

fibroblast growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 9435295. Source: MGI

fibroblast growth factor receptor signaling pathway involved in mammary gland specification

Inferred from mutant phenotype PubMed 16720875. Source: MGI

gland morphogenesis

Inferred from mutant phenotype PubMed 17202188. Source: MGI

hair follicle morphogenesis

Inferred from mutant phenotype PubMed 14530295. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 9435295. Source: MGI

inner ear morphogenesis

Inferred from mutant phenotype PubMed 10934262. Source: MGI

lacrimal gland development

Inferred from mutant phenotype PubMed 10821755. Source: MGI

lateral sprouting from an epithelium

Inferred from mutant phenotype PubMed 12666202. Source: MGI

lens fiber cell development

Inferred from mutant phenotype PubMed 23136392. Source: MGI

limb bud formation

Inferred from mutant phenotype PubMed 10518547PubMed 9435295. Source: MGI

lung alveolus development

Inferred from mutant phenotype PubMed 16989802. Source: MGI

lung development

Inferred from mutant phenotype PubMed 10518547. Source: MGI

lung lobe morphogenesis

Inferred from mutant phenotype PubMed 16989802. Source: MGI

lung-associated mesenchyme development

Inferred from mutant phenotype PubMed 16989802. Source: MGI

mammary gland bud formation

Inferred from mutant phenotype PubMed 11782400. Source: MGI

membranous septum morphogenesis

Inferred from mutant phenotype PubMed 16687131. Source: MGI

mesenchymal cell differentiation

Inferred from genetic interaction PubMed 16442091. Source: MGI

mesenchymal cell differentiation involved in lung development

Inferred from genetic interaction PubMed 16989802. Source: MGI

mesenchymal cell proliferation involved in lung development

Inferred from mutant phenotype PubMed 16989802. Source: MGI

midbrain development

Inferred from genetic interaction PubMed 17687036. Source: MGI

morphogenesis of embryonic epithelium

Inferred from mutant phenotype PubMed 15843416. Source: MGI

multicellular organism growth

Inferred from mutant phenotype PubMed 16989802. Source: MGI

negative regulation of cell proliferation

Inferred from genetic interaction PubMed 18455718. Source: MGI

negative regulation of mitosis

Inferred from genetic interaction PubMed 18455718. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 16989802. Source: MGI

neuromuscular junction development

Inferred from mutant phenotype PubMed 17418794. Source: MGI

odontogenesis

Inferred from mutant phenotype PubMed 17951031. Source: MGI

organ growth

Inferred from mutant phenotype PubMed 16618415. Source: MGI

organ morphogenesis

Inferred from mutant phenotype PubMed 12666202. Source: MGI

otic vesicle formation

Inferred from mutant phenotype PubMed 9435295. Source: MGI

outflow tract septum morphogenesis

Inferred from mutant phenotype PubMed 16687131. Source: MGI

positive regulation of ERK1 and ERK2 cascade

Inferred from genetic interaction PubMed 17202188. Source: MGI

positive regulation of Wnt signaling pathway

Inferred from mutant phenotype PubMed 16989802. Source: MGI

positive regulation of canonical Wnt signaling pathway

Inferred from mutant phenotype PubMed 16720875. Source: MGI

positive regulation of cardiac muscle cell proliferation

Inferred from genetic interaction PubMed 15621532. Source: MGI

positive regulation of cell division

Inferred from mutant phenotype PubMed 14530295. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 14530295PubMed 15199404. Source: MGI

positive regulation of epithelial cell proliferation

Inferred from genetic interaction PubMed 15972105. Source: MGI

positive regulation of epithelial cell proliferation involved in lung morphogenesis

Inferred from mutant phenotype PubMed 16989802. Source: MGI

positive regulation of mesenchymal cell proliferation

Inferred from genetic interaction PubMed 16540513. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 16989802. Source: MGI

post-embryonic development

Inferred from mutant phenotype PubMed 16989802. Source: MGI

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

Inferred from mutant phenotype PubMed 17215304. Source: MGI

prostate epithelial cord elongation

Inferred from mutant phenotype PubMed 17215304. Source: MGI

prostate gland morphogenesis

Inferred from mutant phenotype PubMed 18184727. Source: MGI

regulation of ERK1 and ERK2 cascade

Inferred from mutant phenotype PubMed 16989802. Source: MGI

regulation of branching involved in prostate gland morphogenesis

Inferred from mutant phenotype PubMed 17202188. Source: MGI

regulation of cell fate commitment

Inferred from mutant phenotype PubMed 16989802. Source: MGI

regulation of cell proliferation

Inferred from mutant phenotype PubMed 12756187. Source: MGI

regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 17215304PubMed 18184727. Source: MGI

regulation of fibroblast growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 16989802. Source: MGI

regulation of morphogenesis of a branching structure

Inferred from mutant phenotype PubMed 17202188. Source: MGI

regulation of multicellular organism growth

Inferred from mutant phenotype PubMed 9435295. Source: MGI

regulation of smooth muscle cell differentiation

Inferred from mutant phenotype PubMed 16989802. Source: MGI

regulation of smoothened signaling pathway

Inferred from mutant phenotype PubMed 16618415. Source: MGI

reproductive structure development

Inferred from mutant phenotype PubMed 12666202. Source: MGI

squamous basal epithelial stem cell differentiation involved in prostate gland acinus development

Inferred from mutant phenotype PubMed 17215304. Source: MGI

synaptic vesicle transport

Inferred from mutant phenotype PubMed 17418794. Source: MGI

ureteric bud development

Inferred from genetic interaction PubMed 16442091. Source: MGI

ventricular cardiac muscle tissue morphogenesis

Inferred from mutant phenotype PubMed 16687131. Source: MGI

   Cellular_componentextracellular region

Traceable author statement PubMed 12024206. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from direct assay PubMed 15229180PubMed 15944199. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

fibroblast growth factor binding

Inferred from direct assay PubMed 9435295. Source: MGI

fibroblast growth factor-activated receptor activity

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 16436388PubMed 8393815. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site5571Proton acceptor By similarity PIRSR PIRSR000628-1

Sequences

Sequence LengthMass (Da)Tools
B7ZWP2 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 9E260F6D9D7BF1BE

FASTA75284,511
        10         20         30         40         50         60 
MGLPSTWRYG RGPGIGTVTM VSWGRFICLV LVTMATLSLA RPSFSLVEDT TLEPEDAISS 

        70         80         90        100        110        120 
GDDEDDTDSS EDVVSENRSN QRAPYWTNTE KMEKRLHAVP AANTVKFRCP AGGNPTPTMR 

       130        140        150        160        170        180 
WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CLVENEYGSI NHTYHLDVVE 

       190        200        210        220        230        240 
RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK YGPDGLPYLK 

       250        260        270        280        290        300 
VLKHSGINSS NAEVLALFNV TEMDAGEYIC KVSNYIGQAN QSAWLTVLPK QQAPVREKEI 

       310        320        330        340        350        360 
TASPDYLEIA IYCIGVFLIA CMVVTVIFCR MKTTTKKPDF SSQPAVHKLT KRIPLRRQVT 

       370        380        390        400        410        420 
VSAESSSSMN SNTPLVRITT RLSSTADTPM LAGVSEYELP EDPKWEFPRD KLTLGKPLGE 

       430        440        450        460        470        480 
GCFGQVVMAE AVGIDKDKPK EAVTVAVKML KDDATEKDLS DLVSEMEMMK MIGKHKNIIN 

       490        500        510        520        530        540 
LLGACTQDGP LYVIVEYASK GNLREYLRAR RPPGMEYSYD INRVPEEQMT FKDLVSCTYQ 

       550        560        570        580        590        600 
LARGMEYLAS QKCIHRDLAA RNVLVTENNV MKIADFGLAR DINNIDYYKK TTNGRLPVKW 

       610        620        630        640        650        660 
MAPEALFDRV YTHQSDVWSF GVLMWEIFTL GGSPYPGIPV EELFKLLKEG HRMDKPTNCT 

       670        680        690        700        710        720 
NELYMMMRDC WHAVPSQRPT FKQLVEDLDR ILTLTTNEEY LDLTQPLEQY SPSYPDTRSS 

       730        740        750 
CSSGDDSVFS PDPMPYEPCL PQYPHINGSV KT 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain EMBL AAI72174.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC172174 mRNA. Translation: AAI72174.1.
RefSeqXP_006507417.1. XM_006507354.1.
UniGeneMm.16340.

3D structure databases

ProteinModelPortalB7ZWP2.
SMRB7ZWP2. Positions 81-291, 398-696.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID14183.
KEGGmmu:14183.

Organism-specific databases

CTD2263.
MGIMGI:95523. Fgfr2.

Phylogenomic databases

HOGENOMHOG000263410.
HOVERGENHBG000345.
KOK05093.

Gene expression databases

ArrayExpressB7ZWP2.
BgeeB7ZWP2.
GenevestigatorB7ZWP2.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR028175. FGF_rcpt_2.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERPTHR24416:SF130. PTHR24416:SF130. 1 hit.
PfamPF07679. I-set. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF000628. FGFR. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00408. IGc2. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFGFR2. mouse.
NextBio35547779.
SOURCESearch...

Entry information

Entry nameB7ZWP2_MOUSE
AccessionPrimary (citable) accession number: B7ZWP2
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)