ID B7ZW61_HUMAN Unreviewed; 536 AA. AC B7ZW61; DT 03-MAR-2009, integrated into UniProtKB/TrEMBL. DT 03-MAR-2009, sequence version 1. DT 27-MAR-2024, entry version 89. DE SubName: Full=ZFP57 protein {ECO:0000313|EMBL:AAI71888.1}; GN Name=ZFP57 {ECO:0000313|EMBL:AAI71888.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI71888.1}; RN [1] {ECO:0000313|EMBL:AAI71888.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein CC family. {ECO:0000256|ARBA:ARBA00006991}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC171888; AAI71888.1; -; mRNA. DR RefSeq; NP_001103279.2; NM_001109809.2. DR AlphaFoldDB; B7ZW61; -. DR SMR; B7ZW61; -. DR PeptideAtlas; B7ZW61; -. DR DNASU; 346171; -. DR GeneID; 346171; -. DR KEGG; hsa:346171; -. DR CTD; 346171; -. DR PharmGKB; PA134937821; -. DR OrthoDB; 5265384at2759; -. DR BioGRID-ORCS; 346171; 31 hits in 1164 CRISPR screens. DR GenomeRNAi; 346171; -. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro. DR CDD; cd07765; KRAB_A-box; 1. DR Gene3D; 6.10.140.140; -; 1. DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5. DR InterPro; IPR001909; KRAB. DR InterPro; IPR036051; KRAB_dom_sf. DR InterPro; IPR036236; Znf_C2H2_sf. DR InterPro; IPR013087; Znf_C2H2_type. DR PANTHER; PTHR23232; KRAB DOMAIN C2H2 ZINC FINGER; 1. DR PANTHER; PTHR23232:SF130; RIKEN CDNA 1700020N01 GENE-RELATED; 1. DR Pfam; PF01352; KRAB; 1. DR Pfam; PF00096; zf-C2H2; 5. DR SMART; SM00349; KRAB; 1. DR SMART; SM00355; ZnF_C2H2; 7. DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4. DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1. DR PROSITE; PS50805; KRAB; 1. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7. DR Genevisible; B7ZW61; HS. PE 2: Evidence at transcript level; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00042}. FT DOMAIN 44..116 FT /note="KRAB" FT /evidence="ECO:0000259|PROSITE:PS50805" FT DOMAIN 175..202 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 203..230 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 231..258 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 259..286 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 384..411 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 412..439 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT DOMAIN 440..467 FT /note="C2H2-type" FT /evidence="ECO:0000259|PROSITE:PS50157" FT REGION 494..536 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 536 AA; 61317 MW; 6321DDFF0A6ED77B CRC64; MFEQLKPIEP VQKTLPWVGE VAATLQEAMK RDCWREARVK KKPVTFEDVA VNFTQEEWDC LDASQRVLYQ DVMSETFKNL TSVARIFLHK PELITKLEQE EEQWREFVHL PNTEGLSEGK KKELREQHPS LRDEGTSDDK VFLACRGAGQ CPLSAPAGTM DRTRVLQASQ AGPPFFCYTC DKCFSRRSYL YSHQFVHNPK LTNSCSQCGK LFRSPKSLSY HRRMHLGERP FCCTLCDKTY CDASGLSRHR RVHLGYRPHS CSVCGKSFRD QSELKRHQKI HQNQEPVDGN QECTLRIPGT QAEFQTPIAR SQGSIQGLLD VNHAPVARSQ EPIFRTEGPM AQNQASVLKN QAPVTRTQAP ITGTLCQDAR SNSHPVKPSR LNVFCCPHCS LTFSKKSYLS RHQKAHLTEP PNYCFHCSKS FSSFSRLVRH QQTHWKQKSY LCPICDLSFG EKEGLMDHWR GYKGKDLCQS SHHKCRVILG QWLGFSHDVP TMAGEEWKHG GDQSPPRIHT PRRRGLREKA CKGDKTKEAV SILKHK //