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Protein
Submitted name:

SEPT8 protein

Gene

SEPT8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandGTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
SEPT8 proteinImported
Gene namesi
Name:SEPT8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiB7ZVZ1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367991.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 305Septin-type G (guanine nucleotide-binding)InterPro annotationAdd BLAST265

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili343 – 406Sequence analysisAdd BLAST64

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR030646. SEPT8.
IPR016491. Septin.
PANTHERiPTHR18884. PTHR18884. 1 hit.
PTHR18884:SF90. PTHR18884:SF90. 1 hit.
PfamiView protein in Pfam
PF00735. Septin. 1 hit.
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51719. G_SEPTIN. 1 hit.

Sequencei

Sequence statusi: Complete.

B7ZVZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV
60 70 80 90 100
GETGIGKSTL MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT
110 120 130 140 150
IVDAVGFGDQ INKDERPIVD YIDAQFENYL QEELKIRRSL FDYHDTRIHV
160 170 180 190 200
CLYFITPTGH SLKSLDLVTM KKLDSKVNII PIIAKADTIS KSELHKFKIK
210 220 230 240 250
IMGELVSNGV QIYQFPTDDE AVAEINAVMN AHLPFAVVGS TEEVKVGNKL
260 270 280 290 300
VRARQYPWGV VQVENENHCD FVKLREMLIR VNMEDLREQT HSRHYELYRR
310 320 330 340 350
CKLEEMGFQD SDGDSQPFSL QETYEAKRKE FLSELQRKEE EMRQMFVNKV
360 370 380 390 400
KETELELKEK ERELHEKFEH LKRVHQEEKR KVEEKRRELE EETNAFNRRK
410 420
AAVEALQSQA LHATSQQPLR KDKDKKN
Length:427
Mass (Da):49,564
Last modified:March 3, 2009 - v1
Checksum:i8AF692ABE8C02138
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140759 mRNA. Translation: AAI40760.1.
BC171779 mRNA. Translation: AAI71779.1.
RefSeqiNP_001287727.1. NM_001300798.1.
NP_001287728.1. NM_001300799.1.
UniGeneiHs.522057.

Genome annotation databases

GeneIDi23176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140759 mRNA. Translation: AAI40760.1.
BC171779 mRNA. Translation: AAI71779.1.
RefSeqiNP_001287727.1. NM_001300798.1.
NP_001287728.1. NM_001300799.1.
UniGeneiHs.522057.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367991.

Proteomic databases

PeptideAtlasiB7ZVZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23176.

Organism-specific databases

CTDi23176.

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.

Miscellaneous databases

ChiTaRSiSEPT8. human.
GenomeRNAii23176.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiView protein in InterPro
IPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR030646. SEPT8.
IPR016491. Septin.
PANTHERiPTHR18884. PTHR18884. 1 hit.
PTHR18884:SF90. PTHR18884:SF90. 1 hit.
PfamiView protein in Pfam
PF00735. Septin. 1 hit.
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51719. G_SEPTIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB7ZVZ1_HUMAN
AccessioniPrimary (citable) accession number: B7ZVZ1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: March 15, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.