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B7ZQA9

- P5F12_XENLA

UniProt

B7ZQA9 - P5F12_XENLA

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Protein

POU domain, class 5, transcription factor 1.2

Gene
pou5f1.2, oct-91
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Antagonizes the activity of nodal/activin signaling during gastrulation to suppress mesendoderm formation.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi312 – 37160HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: UniProtKB
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. gastrulation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 5, transcription factor 1.2
Alternative name(s):
POU class V protein oct-91
Short name:
XlPOU91
Short name:
Xoct-91
Gene namesi
Name:pou5f1.2
Synonyms:oct-91
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252587. pou5f3.1.

Subcellular locationi

Nucleus By similarity By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445POU domain, class 5, transcription factor 1.2PRO_0000390497Add
BLAST

Expressioni

Tissue specificityi

Initially (stage 9) expressed in all regions of the embryo, becoming localized to the ventroposterior regions by early neurula stages. In adults, expressed at a low level in the brain.2 Publications

Developmental stagei

Expressed both maternally and zygotically. Expressed at low levels in oocytes, with expression increasing rapidly during gastrulation and peaking during late gastrulation before declining through neurulation.2 Publications

Interactioni

Subunit structurei

Interacts with the transcription factors tcf7l1/tcf3 and vegt.1 Publication

Protein-protein interaction databases

IntActiB7ZQA9. 2 interactions.
MINTiMINT-4979404.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini218 – 29275POU-specificAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi167 – 21650Ser-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053782.
KOiK09367.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZQA9-1 [UniParc]FASTAAdd to Basket

« Hide

MYNQQTYPSF THNPALMPDG SGQYNLGTYT GMARHPHQAQ AFFPFSGVKS    50
DYGDLGGQTT SVGDTSAWNP LTSLDSANQL GISGQGNPFK NLKREREDDE 100
EKSESPEPKC SPPSLPPAYY THAWNPTTTF WSQVSSSGTT VVSKPLPTPL 150
QPGDKCDPVE ANKIFTSSPD KSGESGISSL DNSRCSSATS SSSGGTNVGT 200
PRSLSRGASD GLSSDSEEEA PNSGEMEQFA KDLKHKRITM GYTQADVGYA 250
LGVLFGKTFS QTTICRFESL QLSFKNMCKL KPLLRSWLHE VENNENLQEI 300
ISRGQIIPQV QKRKHRTSIE NNVKCTLENY FMQCSKPSAQ EIAQIARELN 350
MEKDVVRVWF CNRRQKGKRQ VYPYIRENGG EPYDAPQTLT PPSQGPFPLP 400
QVMPSQVFPT VPLGANPTIY VPTYHKNDMF PQAMHHGIGM GNQGN 445
Length:445
Mass (Da):49,036
Last modified:March 3, 2009 - v1
Checksum:iC981C1F3A2EDA93C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481G → A1 Publication
Sequence conflicti295 – 2951E → K in AAA49999. 1 Publication
Sequence conflicti333 – 3331Q → G1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60077 mRNA. Translation: AAA49999.1.
BC169741 mRNA. Translation: AAI69741.1.
BC169743 mRNA. Translation: AAI69743.1.
PIRiC42022.
RefSeqiNP_001081342.1. NM_001087873.1.
UniGeneiXl.870.
Xl.871.

Genome annotation databases

GeneIDi397784.
KEGGixla:397784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60077 mRNA. Translation: AAA49999.1 .
BC169741 mRNA. Translation: AAI69741.1 .
BC169743 mRNA. Translation: AAI69743.1 .
PIRi C42022.
RefSeqi NP_001081342.1. NM_001087873.1.
UniGenei Xl.870.
Xl.871.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi B7ZQA9. 2 interactions.
MINTi MINT-4979404.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397784.
KEGGi xla:397784.

Organism-specific databases

CTDi 397784.
Xenbasei XB-GENE-6252587. pou5f3.1.

Phylogenomic databases

HOVERGENi HBG053782.
KOi K09367.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequential expression of multiple POU proteins during amphibian early development."
    Hinkley C.S., Martin J.F., Leibham D., Perry M.
    Mol. Cell. Biol. 12:638-649(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Gastrula.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.
  3. "Localized expression of a Xenopus POU gene depends on cell-autonomous transcriptional activation and induction-dependent inactivation."
    Frank D., Harland R.M.
    Development 115:439-448(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 236-362, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Gastrula.
  4. "Xenopus POU factors of subclass V inhibit activin/nodal signaling during gastrulation."
    Cao Y., Siegel D., Knochel W.
    Mech. Dev. 123:614-625(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos."
    Cao Y., Siegel D., Donow C., Knochel S., Yuan L., Knochel W.
    EMBO J. 26:2942-2954(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TCF7L1 AND VEGT.

Entry informationi

Entry nameiP5F12_XENLA
AccessioniPrimary (citable) accession number: B7ZQA9
Secondary accession number(s): Q03917, Q9PSI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: March 3, 2009
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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