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B7ZN95 (B7ZN95_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Cacna1c EMBL AAI45105.1 MGI 103013
OrganismMus musculus (Mouse) EMBL AAI45105.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length2139 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS027359
   LigandCalcium
   Molecular functionCalcium channel RuleBase RU003808
Ion channel
Voltage-gated channel RuleBase RU003808
Gene Ontology (GO)
   Biological_processadult walking behavior

Inferred from genetic interaction PubMed 9882694. Source: MGI

calcium ion transport

Inferred from direct assay PubMed 7635187. Source: MGI

calcium ion-dependent exocytosis

Inferred from mutant phenotype PubMed 12881419. Source: MGI

cellular calcium ion homeostasis

Inferred from mutant phenotype PubMed 15132976. Source: MGI

glucose homeostasis

Inferred from mutant phenotype PubMed 12881419. Source: MGI

growth hormone secretion

Inferred from direct assay PubMed 1385406. Source: MGI

insulin secretion

Inferred from mutant phenotype PubMed 12881419. Source: MGI

regulation of blood pressure

Inferred from mutant phenotype PubMed 14609949. Source: MGI

regulation of organ growth

Inferred from mutant phenotype PubMed 15132976. Source: MGI

regulation of vasoconstriction

Inferred from mutant phenotype PubMed 14609949. Source: MGI

smooth muscle contraction

Inferred from mutant phenotype PubMed 16636102. Source: MGI

smooth muscle contraction involved in micturition

Inferred from mutant phenotype PubMed 15132976. Source: MGI

synaptic transmission

Inferred from mutant phenotype PubMed 16251435. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 16251435. Source: MGI

   Cellular_componentT-tubule

Traceable author statement PubMed 11784029. Source: MGI

Z disc

Inferred from direct assay PubMed 19383796. Source: MGI

caveolar macromolecular signaling complex

Inferred from direct assay PubMed 16648270. Source: MGI

dendritic shaft

Inferred from direct assay PubMed 15090038. Source: MGI

membrane

Inferred from direct assay PubMed 15132976. Source: MGI

neuronal cell body

Inferred from direct assay PubMed 15090038. Source: MGI

plasma membrane

Inferred from direct assay PubMed 15090038PubMed 7598723. Source: MGI

voltage-gated calcium channel complex

Traceable author statement PubMed 11296258. Source: MGI

   Molecular_functionvoltage-gated calcium channel activity

Inferred from direct assay PubMed 1385406PubMed 16267232PubMed 7635187PubMed 7814415. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B7ZN95 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: C6EE62B712D4B344

FASTA2,139240,108
        10         20         30         40         50         60 
MVNENTRMYV PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL SWQAAIDAAR 

        70         80         90        100        110        120 
QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGGTTATRP PRALLCLTLK NPIRRACISI 

       130        140        150        160        170        180 
VEWKPFEIII LLTIFANCVA LAIYIPFPED DSNATNSNLE RVEYLFLIIF TVEAFLKVIA 

       190        200        210        220        230        240 
YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR 

       250        260        270        280        290        300 
VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN 

       310        320        330        340        350        360 
QEGIIDVPAE EDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA FAMLTVFQCI 

       370        380        390        400        410        420 
TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI FGSFFVLNLV LGVLSGEFSK EREKAKARGD 

       430        440        450        460        470        480 
FQKLREKQQL EEDLKGYLDW ITQAEDIDPE NEDEGMDEDK PRNMSMPTSE TESVNTENVA 

       490        500        510        520        530        540 
GGDIEGENCG ARLAHRISKS KFSRYWRRWN RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT 

       550        560        570        580        590        600 
IASEHYNQPH WLTEVQDTAN KALLALFTAE MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI 

       610        620        630        640        650        660 
LETILVETKI MSPLGISVLR CVRLLRIFKI TRYWNSLSNL VASLLNSVRS IASLLLLLFL 

       670        680        690        700        710        720 
FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD NFPQSLLTVF QILTGEDWNS VMYDGIMAYG 

       730        740        750        760        770        780 
GPSFPGMLVC IYFIILFICG NYILLNVFLA IAVDNLADAE SLTSAQKEEE EEKERKKLAR 

       790        800        810        820        830        840 
TASPEKKQEV MEKPAVEESK EEKIELKSIT ADGESPPTTK INMDDLQPSE NEDKSPHSNP 

       850        860        870        880        890        900 
DTAGEEDEEE PEMPVGPRPR PLSELHLKEK AVPMPEASAF FIFSPNNRFR LQCHRIVNDT 

       910        920        930        940        950        960 
IFTNLILFFI LLSSISLAAE DPVQHTSFRN HILGNADYVF TSIFTLEIIL KMTAYGAFLH 

       970        980        990       1000       1010       1020 
KGSFCRNYFN ILDLLVVSVS LISFGIQSSA INVVKILRVL RVLRPLRAIN RAKGLKHVVQ 

      1030       1040       1050       1060       1070       1080 
CVFVAIRTIG NIVIVTTLLQ FMFACIGVQL FKGKLYTCSD SSKQTEAECK GNYITYKDGE 

      1090       1100       1110       1120       1130       1140 
VDHPIIQPRS WENSKFDFDN VLAAMMALFT VSTFEGWPEL LYRSIDSHTE DKGPIYNYRV 

      1150       1160       1170       1180       1190       1200 
EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEQEYKNC ELGKNQRQCV EYALKARPLR 

      1210       1220       1230       1240       1250       1260 
RYIPKNQHQY KVWYVVNSTY FEYLMFVLIL LNTICLAMQH YGQSCLFKIA MNILNMLFTG 

      1270       1280       1290       1300       1310       1320 
LFTVEMILKL IAFKPKGYFS DPWNVFDFLI VIGSIIDVIL SETNPAEHTQ CSPSMSAEEN 

      1330       1340       1350       1360       1370       1380 
SRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIVML FFIYAVIGMQ 

      1390       1400       1410       1420       1430       1440 
VFGKIALNDT TEINRNNNFQ TFPQAVLLLF RCATGEAWQD IMLACMPGKK CAPESEPSNS 

      1450       1460       1470       1480       1490       1500 
TEGETPCGSS FAVFYFISFY MLCAFLIINL FVAVIMDNFD YLTRDWSILG PHHLDEFKRI 

      1510       1520       1530       1540       1550       1560 
WAEYDPEAKG RIKHLDVVTL LRRIQPPLGF GKLCPHRVAC KRLVSMNMPL NSDGTVMFNA 

      1570       1580       1590       1600       1610       1620 
TLFALVRTAL RIKTEGNLEQ ANEELRAIIK KIWKRTSMKL LDQVVPPAGD DEVTVGKFYA 

      1630       1640       1650       1660       1670       1680 
TFLIQEYFRK FKKRKEQGLV GKPSQRNALS LQAGLRTLHD IGPEIRRAIS GDLTAEEELD 

      1690       1700       1710       1720       1730       1740 
KAMKEAVSAA SEDDIFRRAG GLFGNHVTYY QSDSRGNFPQ TFATQRPLHI NKTGNNQADT 

      1750       1760       1770       1780       1790       1800 
ESPSHEKLVD STFTPSSYSS TGSNANINNA NNTALGRFPH PAGYSSTVST VEGHGPPLSP 

      1810       1820       1830       1840       1850       1860 
AVRVQEAAWK LSSKRCHSRE SQGATVNQEI FPDETRSVRM SEEAEYCSEP SLLSTDMFSY 

      1870       1880       1890       1900       1910       1920 
QEDEHRQLTC PEEDKREIQP SPKRSFLRSA SLGRRASFHL ECLKRQKDQG GDISQKTALP 

      1930       1940       1950       1960       1970       1980 
LHLVHHQALA VAGLSPLLQR SHSPTTFPRP CPTPPVTPGS RGRPLRPIPT LRLEGAESSE 

      1990       2000       2010       2020       2030       2040 
KLNSSFPSIH CSSWSEETTA CSGSSSMARR ARPVSLTVPS QAGAPGRQFH GSASSLVEAV 

      2050       2060       2070       2080       2090       2100 
LISEGLGQFA QDPKFIEVTT QELADACDMT IEEMENAADN ILSGGAQQSP NGTLLPFVNC 

      2110       2120       2130 
RDPGQDRAVV PEDESCAYAL GRGRSEEALA DSRSYVSNL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain EMBL AAI45105.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC145104 mRNA. Translation: AAI45105.1.
RefSeqNP_001153005.1. NM_001159533.1.
NP_001153007.1. NM_001159535.1.
UniGeneMm.436656.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID12288.
KEGGmmu:12288.

Organism-specific databases

CTD775.
MGIMGI:103013. Cacna1c.

Phylogenomic databases

HOVERGENHBG050763.
KOK04850.

Gene expression databases

GenevestigatorB7ZN95.

Family and domain databases

Gene3D1.20.120.350. 4 hits.
InterProIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCACNA1C. mouse.
NextBio280766.
SOURCESearch...

Entry information

Entry nameB7ZN95_MOUSE
AccessionPrimary (citable) accession number: B7ZN95
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)