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Protein

Erythropoietin

Gene

Epo

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormoneUniRule annotation
Biological processErythrocyte maturationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
ErythropoietinUniRule annotation
Gene namesi
Name:EpoImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95407 Epo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501456845024 – 191ErythropoietinSequence analysisAdd BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 186UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000029711

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the EPO/TPO family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IHW5 Eukaryota
ENOG410XTRF LUCA
GeneTreeiENSGT00390000017226
HOGENOMiHOG000052505
HOVERGENiHBG003978

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR019767 EPO/TPO_CS
IPR001323 EPO_TPO
IPR003013 Erythroptn
PANTHERiPTHR10370 PTHR10370, 1 hit
PfamiView protein in Pfam
PF00758 EPO_TPO, 1 hit
PIRSFiPIRSF001951 EPO, 1 hit
PRINTSiPR00272 ERYTHROPTN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00817 EPO_TPO, 1 hit

Sequencei

Sequence statusi: Complete.

B7ZMY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPERPTLL LLLSLLLIPL GLPVLCAPPR LICDSRVLER YILEAKEAEN
60 70 80 90 100
VTMGCAEGPR LSENITVPDT KVNFYAWKRM EVEEQAIEVW QGLSLLSEAI
110 120 130 140 150
LQAQALLANS SQPPETLQLH IDKAISGLRS LTSLLRVLGA QELMSPPDTT
160 170 180 190
PPAPLRTLTV DTFCKLFRVY ANFLRGKLKL YTGEVCRRGD R
Length:191
Mass (Da):21,237
Last modified:March 3, 2009 - v1
Checksum:iE3530A426E25352A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148018 Genomic DNA No translation available.
BC144887 mRNA Translation: AAI44888.1
RefSeqiNP_001299804.1, NM_001312875.1
UniGeneiMm.349116

Genome annotation databases

EnsembliENSMUST00000111039; ENSMUSP00000106668; ENSMUSG00000029711
GeneIDi13856
UCSCiuc012eez.2 mouse

Similar proteinsi

Entry informationi

Entry nameiB7ZMY9_MOUSE
AccessioniPrimary (citable) accession number: B7ZMY9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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