Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Erythropoietin

Gene

Epo

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormoneUniRule annotation
Biological processErythrocyte maturationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
ErythropoietinUniRule annotation
Gene namesi
Name:EpoImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95407. Epo.

Subcellular locationi

  • Secreted UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501082718824 – 191ErythropoietinSequence analysisAdd BLAST168

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 186UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000029711.

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the EPO/TPO family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IHW5. Eukaryota.
ENOG410XTRF. LUCA.
GeneTreeiENSGT00390000017226.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiView protein in Pfam
PF00758. EPO_TPO. 1 hit.
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiView protein in PROSITE
PS00817. EPO_TPO. 1 hit.

Sequencei

Sequence statusi: Complete.

B7ZMY9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVPERPTLL LLLSLLLIPL GLPVLCAPPR LICDSRVLER YILEAKEAEN
60 70 80 90 100
VTMGCAEGPR LSENITVPDT KVNFYAWKRM EVEEQAIEVW QGLSLLSEAI
110 120 130 140 150
LQAQALLANS SQPPETLQLH IDKAISGLRS LTSLLRVLGA QELMSPPDTT
160 170 180 190
PPAPLRTLTV DTFCKLFRVY ANFLRGKLKL YTGEVCRRGD R
Length:191
Mass (Da):21,237
Last modified:March 3, 2009 - v1
Checksum:iE3530A426E25352A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC148018 Genomic DNA. No translation available.
BC144887 mRNA. Translation: AAI44888.1.
RefSeqiNP_001299804.1. NM_001312875.1.
UniGeneiMm.349116.

Genome annotation databases

EnsembliENSMUST00000111039; ENSMUSP00000106668; ENSMUSG00000029711.
GeneIDi13856.
UCSCiuc012eez.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiB7ZMY9_MOUSE
AccessioniPrimary (citable) accession number: B7ZMY9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: August 30, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported