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Protein
Submitted name:

ITPR1 protein

Gene

ITPR1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
ITPR1 proteinImported
Submitted name:
Inositol 1,4,5-trisphosphate receptor type 1Imported
Gene namesi
Name:ITPR1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:6180. ITPR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei367 – 392HelicalSequence analysisAdd BLAST26
Transmembranei412 – 434HelicalSequence analysisAdd BLAST23
Transmembranei542 – 565HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150995.

PTM / Processingi

Proteomic databases

MaxQBiB7ZMI3.

Expressioni

Gene expression databases

BgeeiENSG00000150995.
ExpressionAtlasiB7ZMI3. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 166MIRInterPro annotationAdd BLAST55
Domaini173 – 223MIRInterPro annotationAdd BLAST51
Domaini231 – 287MIRInterPro annotationAdd BLAST57
Domaini294 – 344MIRInterPro annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili659 – 700Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
GeneTreeiENSGT00760000119152.
HOVERGENiHBG106626.

Family and domain databases

InterProiView protein in InterPro
IPR014821. Ins145_P3_rcpt.
IPR000493. InsP3_rcpt-bd.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR015925. Ryanodine_recept-rel.
PANTHERiPTHR13715. PTHR13715. 1 hit.
PfamiView protein in Pfam
PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PRINTSiPR00779. INSP3RECEPTR.
SMARTiView protein in SMART
SM00472. MIR. 4 hits.
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiView protein in PROSITE
PS50919. MIR. 4 hits.

Sequencei

Sequence statusi: Complete.

B7ZMI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PETGDLNNPP
60 70 80 90 100
KKFRDCLFKL CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK
110 120 130 140 150
KQNETENRKL LGTVIQYGNV IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT
160 170 180 190 200
LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD KVVLNPVNAG QPLHASSHQL
210 220 230 240 250
VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV RLFHAEQEKF
260 270 280 290 300
LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
310 320 330 340 350
SLFRFKHLAT GHYLAAEVDP DFEEECLEFQ PSVCNKIIFL MSFVGNCGTF
360 370 380 390 400
TRGYRAMVLD VEFLYHLLYL VICAMGLFVH EFFYSLLLFD LVYREETLLN
410 420 430 440 450
VIKSVTRNGR SIILTAVLAL ILVYLFSIVG YLFFKDDFIL EVDRLPNETA
460 470 480 490 500
VPETGESLAS EFLFSDVCRV ESGENCSSPA PREELVPAEE TEQDKEHTCE
510 520 530 540 550
TLLMCIVTVL SHGLRSGGGV GDVLRKPSKE EPLFAARVIY DLLFFFMVII
560 570 580 590 600
IVLNLIFGVI IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVTFE
610 620 630 640 650
EHIKEEHNMW HYLCFIVLVK VKDSTEYTGP ESYVAEMIKE RNLDWFPRMR
660 670 680 690 700
AMSLVSSDSE GEQNELRNLQ EKLESTMKLV TNLSGQLSEL KDQMTEQRKQ
710 720
KQRIGLLGHP PHMNVNPQQP A
Length:721
Mass (Da):81,948
Last modified:March 3, 2009 - v1
Checksum:iCB9B37B5E5BD50C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC024168 Genomic DNA. No translation available.
AC069248 Genomic DNA. No translation available.
AC090944 Genomic DNA. No translation available.
KF457537 Genomic DNA. No translation available.
KF457539 Genomic DNA. No translation available.
KF457546 Genomic DNA. No translation available.
KF495812 Genomic DNA. No translation available.
BC144563 mRNA. Translation: AAI44564.1.
UniGeneiHs.567295.
Hs.715765.

Genome annotation databases

EnsembliENST00000544951; ENSP00000440564; ENSG00000150995.
UCSCiuc011asu.2. human.

Similar proteinsi

Entry informationi

Entry nameiB7ZMI3_HUMAN
AccessioniPrimary (citable) accession number: B7ZMI3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 5, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported