ID   B7ZMI2_HUMAN            Unreviewed;      1194 AA.
AC   B7ZMI2;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   SubName: Full=ARAP1 protein {ECO:0000313|EMBL:AAI44563.1};
GN   Name=ARAP1 {ECO:0000313|EMBL:AAI44563.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAI44563.1};
RN   [1] {ECO:0000313|EMBL:AAI44563.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI44563.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC144562; AAI44563.1; -; mRNA.
DR   AlphaFoldDB; B7ZMI2; -.
DR   IntAct; B7ZMI2; 1.
DR   PeptideAtlas; B7ZMI2; -.
DR   ChiTaRS; ARAP1; human.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd08837; ArfGap_ARAP; 1.
DR   CDD; cd13253; PH1_ARAP; 1.
DR   CDD; cd13254; PH2_ARAP; 1.
DR   CDD; cd13256; PH3_ARAP; 1.
DR   CDD; cd13257; PH4_ARAP; 1.
DR   CDD; cd13259; PH5_ARAP; 1.
DR   CDD; cd17226; RA_ARAP1; 1.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 3.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 5.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 5.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 4.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          82..174
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          195..284
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          290..415
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   DOMAIN          498..605
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          709..894
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          927..1016
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          1029..1140
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          21..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..42
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1194 AA;  134706 MW;  8A9B8A64D08DF9C4 CRC64;
     MTKKEEPPPS RVPRAVRVAS LLSEGEELSG DDQGDEEEDD HAYEGVPNGG WHTSSLSLSL
     PSTIAAPHPM DGPPGGSTPV TPVIKAGWLD KNPPQGSYIY QKRWVRLDTD HLRYFDSNKD
     AYSKRFISVA CISHVAAIGD QKFEVITNNR TFAFRAESDV ERKEWMQALQ QAMAEQRARA
     RLSSAYLLGV PGSEQPDRAG SLELRGFKNK LYVAVVGDKV QLYKNLEEYH LGIGITFIDM
     SVGNVKEVDR RSFDLTTPYR IFSFSADSEL EKEQWLEAMQ GAIAEALSTS EVAERIWAAA
     PNRFCADCGA PQPDWASINL CVVICKRCAG EHRGLGAGVS KVRSLKMDRK VWTETLIELF
     LQLGNGAGNR FWAANVPPSE ALQPSSSPST RRCHLEAKYR EGKYRRYHPL FGNQEELDKA
     LCAAVTTTDL AETQALLGCG AGINCFSGDP EAPTPLALAE QAGQTLQMEF LRNNRTTEVP
     RLDSMKPLEK HYSVVLPTVS HSGFLYKTAS AGKLLQDRRA REEFSRRWCV LGDGVLSYFE
     NERAVTPNGE IRASEIVCLA VPPPDTHGFE HTFEVYTEGE RLYLFGLESA EQAHEWVKCI
     AKAFVPPLAE DLLARDFERL GRLPYKAGLS LQRAQEGWFS LSGSELRAVF PEGPCEEPLQ
     LRKLQELSIQ GDSENQVLVL VERRRTLYIQ GERRLDFMGW LGAIQKAAAS MGDTLSEQQL
     GDSDIPVIVY RCVDYITQCG LTSEGIYRKC GQTSKTQRLL ERLRQDARSV HLKEGEQHVD
     DVSSALKRFL RDLPDGLFTR AQRLTWLEAS EIEDEEEKVS RYRELLVRLP PVNRATVKAL
     ISHLYCVQCF SDTNQMNVHN LAIVFGPTLF QTDGQDYKAG RVVEDLINHY VVVFSVDEEE
     LRKQREEITA IVKMRVAGTA SGTQHAGDFI CTVYLEEKKA ETEQHIKVPA SMTAEELTLE
     ILDRRNVGIR EKDYWTCFEV NEREEAERPL HFAEKVLPIL HGLGTDSHLV VKKHQAMEAM
     LLYLASRVGD TKHGMMKFRE DRSLLGLGLP SGGFHDRYFI LNSSCLRLYK EVRSHRPEKE
     WPIKSLKVYL GVKKKLRPPT CWGFTVVHET EKHEKQQWYL CCDTQMELRE WFATFLFVQH
     DGLVWPSEPS RVSRAVPEVR LGSVSLIPLR GSENEMRRSV AAFTADPLSL LRNV
//