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B7ZMI2

- B7ZMI2_HUMAN

UniProt

B7ZMI2 - B7ZMI2_HUMAN

Protein
Submitted name:

ARAP1 protein

Gene

ARAP1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of ARF GTPase activity Source: InterPro
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ARAP1 proteinImported
    Gene namesi
    Name:ARAP1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Proteomic databases

    PRIDEiB7ZMI2.

    Interactioni

    Protein-protein interaction databases

    IntActiB7ZMI2. 1 interaction.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 Rho-GAP domain.
    Contains 5 PH domains.UniRule annotation
    Contains Arf-GAP domain.SAAS annotation
    Contains Rho-GAP domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000246988.
    HOVERGENiHBG106625.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    2.30.29.30. 4 hits.
    InterProiIPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000159. Ras-assoc.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view]
    PfamiPF01412. ArfGap. 1 hit.
    PF00169. PH. 3 hits.
    PF00788. RA. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00105. ArfGap. 1 hit.
    SM00233. PH. 5 hits.
    SM00324. RhoGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    PROSITEiPS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 4 hits.
    PS50200. RA. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7ZMI2-1 [UniParc]FASTAAdd to Basket

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    MTKKEEPPPS RVPRAVRVAS LLSEGEELSG DDQGDEEEDD HAYEGVPNGG     50
    WHTSSLSLSL PSTIAAPHPM DGPPGGSTPV TPVIKAGWLD KNPPQGSYIY 100
    QKRWVRLDTD HLRYFDSNKD AYSKRFISVA CISHVAAIGD QKFEVITNNR 150
    TFAFRAESDV ERKEWMQALQ QAMAEQRARA RLSSAYLLGV PGSEQPDRAG 200
    SLELRGFKNK LYVAVVGDKV QLYKNLEEYH LGIGITFIDM SVGNVKEVDR 250
    RSFDLTTPYR IFSFSADSEL EKEQWLEAMQ GAIAEALSTS EVAERIWAAA 300
    PNRFCADCGA PQPDWASINL CVVICKRCAG EHRGLGAGVS KVRSLKMDRK 350
    VWTETLIELF LQLGNGAGNR FWAANVPPSE ALQPSSSPST RRCHLEAKYR 400
    EGKYRRYHPL FGNQEELDKA LCAAVTTTDL AETQALLGCG AGINCFSGDP 450
    EAPTPLALAE QAGQTLQMEF LRNNRTTEVP RLDSMKPLEK HYSVVLPTVS 500
    HSGFLYKTAS AGKLLQDRRA REEFSRRWCV LGDGVLSYFE NERAVTPNGE 550
    IRASEIVCLA VPPPDTHGFE HTFEVYTEGE RLYLFGLESA EQAHEWVKCI 600
    AKAFVPPLAE DLLARDFERL GRLPYKAGLS LQRAQEGWFS LSGSELRAVF 650
    PEGPCEEPLQ LRKLQELSIQ GDSENQVLVL VERRRTLYIQ GERRLDFMGW 700
    LGAIQKAAAS MGDTLSEQQL GDSDIPVIVY RCVDYITQCG LTSEGIYRKC 750
    GQTSKTQRLL ERLRQDARSV HLKEGEQHVD DVSSALKRFL RDLPDGLFTR 800
    AQRLTWLEAS EIEDEEEKVS RYRELLVRLP PVNRATVKAL ISHLYCVQCF 850
    SDTNQMNVHN LAIVFGPTLF QTDGQDYKAG RVVEDLINHY VVVFSVDEEE 900
    LRKQREEITA IVKMRVAGTA SGTQHAGDFI CTVYLEEKKA ETEQHIKVPA 950
    SMTAEELTLE ILDRRNVGIR EKDYWTCFEV NEREEAERPL HFAEKVLPIL 1000
    HGLGTDSHLV VKKHQAMEAM LLYLASRVGD TKHGMMKFRE DRSLLGLGLP 1050
    SGGFHDRYFI LNSSCLRLYK EVRSHRPEKE WPIKSLKVYL GVKKKLRPPT 1100
    CWGFTVVHET EKHEKQQWYL CCDTQMELRE WFATFLFVQH DGLVWPSEPS 1150
    RVSRAVPEVR LGSVSLIPLR GSENEMRRSV AAFTADPLSL LRNV 1194
    Length:1,194
    Mass (Da):134,706
    Last modified:March 3, 2009 - v1
    Checksum:i8A9B8A64D08DF9C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC144562 mRNA. Translation: AAI44563.1.
    UniGeneiHs.503165.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC144562 mRNA. Translation: AAI44563.1 .
    UniGenei Hs.503165.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi B7ZMI2. 1 interaction.

    Proteomic databases

    PRIDEi B7ZMI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000246988.
    HOVERGENi HBG106625.

    Miscellaneous databases

    ChiTaRSi ARAP1. human.
    NextBioi 35481437.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    2.30.29.30. 4 hits.
    InterProi IPR001164. ArfGAP.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000159. Ras-assoc.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view ]
    Pfami PF01412. ArfGap. 1 hit.
    PF00169. PH. 3 hits.
    PF00788. RA. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00105. ArfGap. 1 hit.
    SM00233. PH. 5 hits.
    SM00324. RhoGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    PROSITEi PS50115. ARFGAP. 1 hit.
    PS50003. PH_DOMAIN. 4 hits.
    PS50200. RA. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.

    Entry informationi

    Entry nameiB7ZMI2_HUMAN
    AccessioniPrimary (citable) accession number: B7ZMI2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.