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Protein
Submitted name:

ARAP1 protein

Gene

ARAP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ARF GTPase activator activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of ARF GTPase activity Source: InterPro
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
ARAP1 proteinImported
Gene namesi
Name:ARAP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiB7ZMI2.

Interactioni

Protein-protein interaction databases

IntActiB7ZMI2. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Contains 5 PH domains.UniRule annotation
Contains Arf-GAP domain.SAAS annotation
Contains Rho-GAP domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000246988.
HOVERGENiHBG106625.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProiIPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 3 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZMI2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTKKEEPPPS RVPRAVRVAS LLSEGEELSG DDQGDEEEDD HAYEGVPNGG
60 70 80 90 100
WHTSSLSLSL PSTIAAPHPM DGPPGGSTPV TPVIKAGWLD KNPPQGSYIY
110 120 130 140 150
QKRWVRLDTD HLRYFDSNKD AYSKRFISVA CISHVAAIGD QKFEVITNNR
160 170 180 190 200
TFAFRAESDV ERKEWMQALQ QAMAEQRARA RLSSAYLLGV PGSEQPDRAG
210 220 230 240 250
SLELRGFKNK LYVAVVGDKV QLYKNLEEYH LGIGITFIDM SVGNVKEVDR
260 270 280 290 300
RSFDLTTPYR IFSFSADSEL EKEQWLEAMQ GAIAEALSTS EVAERIWAAA
310 320 330 340 350
PNRFCADCGA PQPDWASINL CVVICKRCAG EHRGLGAGVS KVRSLKMDRK
360 370 380 390 400
VWTETLIELF LQLGNGAGNR FWAANVPPSE ALQPSSSPST RRCHLEAKYR
410 420 430 440 450
EGKYRRYHPL FGNQEELDKA LCAAVTTTDL AETQALLGCG AGINCFSGDP
460 470 480 490 500
EAPTPLALAE QAGQTLQMEF LRNNRTTEVP RLDSMKPLEK HYSVVLPTVS
510 520 530 540 550
HSGFLYKTAS AGKLLQDRRA REEFSRRWCV LGDGVLSYFE NERAVTPNGE
560 570 580 590 600
IRASEIVCLA VPPPDTHGFE HTFEVYTEGE RLYLFGLESA EQAHEWVKCI
610 620 630 640 650
AKAFVPPLAE DLLARDFERL GRLPYKAGLS LQRAQEGWFS LSGSELRAVF
660 670 680 690 700
PEGPCEEPLQ LRKLQELSIQ GDSENQVLVL VERRRTLYIQ GERRLDFMGW
710 720 730 740 750
LGAIQKAAAS MGDTLSEQQL GDSDIPVIVY RCVDYITQCG LTSEGIYRKC
760 770 780 790 800
GQTSKTQRLL ERLRQDARSV HLKEGEQHVD DVSSALKRFL RDLPDGLFTR
810 820 830 840 850
AQRLTWLEAS EIEDEEEKVS RYRELLVRLP PVNRATVKAL ISHLYCVQCF
860 870 880 890 900
SDTNQMNVHN LAIVFGPTLF QTDGQDYKAG RVVEDLINHY VVVFSVDEEE
910 920 930 940 950
LRKQREEITA IVKMRVAGTA SGTQHAGDFI CTVYLEEKKA ETEQHIKVPA
960 970 980 990 1000
SMTAEELTLE ILDRRNVGIR EKDYWTCFEV NEREEAERPL HFAEKVLPIL
1010 1020 1030 1040 1050
HGLGTDSHLV VKKHQAMEAM LLYLASRVGD TKHGMMKFRE DRSLLGLGLP
1060 1070 1080 1090 1100
SGGFHDRYFI LNSSCLRLYK EVRSHRPEKE WPIKSLKVYL GVKKKLRPPT
1110 1120 1130 1140 1150
CWGFTVVHET EKHEKQQWYL CCDTQMELRE WFATFLFVQH DGLVWPSEPS
1160 1170 1180 1190
RVSRAVPEVR LGSVSLIPLR GSENEMRRSV AAFTADPLSL LRNV
Length:1,194
Mass (Da):134,706
Last modified:March 3, 2009 - v1
Checksum:i8A9B8A64D08DF9C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144562 mRNA. Translation: AAI44563.1.
UniGeneiHs.503165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144562 mRNA. Translation: AAI44563.1.
UniGeneiHs.503165.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB7ZMI2. 1 interaction.

Proteomic databases

PRIDEiB7ZMI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000246988.
HOVERGENiHBG106625.

Miscellaneous databases

ChiTaRSiARAP1. human.
NextBioi35481437.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
2.30.29.30. 4 hits.
InterProiIPR001164. ArfGAP.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000159. Ras-assoc.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 3 hits.
PF00788. RA. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 5 hits.
SM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 4 hits.
PS50200. RA. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.

Entry informationi

Entry nameiB7ZMI2_HUMAN
AccessioniPrimary (citable) accession number: B7ZMI2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.