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Protein
Submitted name:

MTHFD1L protein

Gene

MTHFD1L

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MTHFD1L proteinImported
Submitted name:
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-likeImported
Submitted name:
Monofunctional C1-tetrahydrofolate synthase, mitochondrialImported
Gene namesi
Name:MTHFD1LImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21055. MTHFD1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120254.

Expressioni

Gene expression databases

BgeeiENSG00000120254.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000356290.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 180THF_DHG_CYHInterPro annotationAdd BLAST107
Domaini184 – 302THF_DHG_CYH_CInterPro annotationAdd BLAST119

Phylogenomic databases

eggNOGiKOG4230. Eukaryota.
COG0190. LUCA.
COG2759. LUCA.
GeneTreeiENSGT00860000133777.
HOGENOMiHOG000040280.
HOVERGENiHBG004916.
OMAiCSHDFLS.
OrthoDBiEOG091G01BU.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
3.40.50.720. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR016040. NAD(P)-bd_dom.
IPR027417. P-loop_NTPase.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
PF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZM99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRLPLVLR QLRRPPQPPG PPRRLRVPCR ASSGGGGGGG GGREGLLGQR
60 70 80 90 100
RPQDGQARSS CSPGGRTPAA RDSIVREVIQ NSKEVLSLLQ EKNPAFKPVL
110 120 130 140 150
AIIQAGDDNL MQEINQNLAE EAGLNITHIC LPPDSSEAEI IDEILKINED
160 170 180 190 200
TRVHGLALQI SENLFSNKVL NALKPEKDVD GVTDINLGKL VRGDAHECFV
210 220 230 240 250
SPVAKAVIEL LEKSVGVNLD GKKILVVGAH GSLEAALQCL FQRKGSMTMS
260 270 280 290 300
IQWKTRQLQS KLHEADIVVL GSPKPEEIPL TWIQPGTTVL NCSHDFLSGK
310 320 330 340 350
VGCGSPRIHF GGLIEEDDVI LLAAALRIQN MVSSGRRWLR EQQHRRWRLH
360 370 380 390 400
CLKLQPLSPV PSDIEISRGQ TPKAVDVLAK EIGLLADEIE IYGKSKAKVR
410 420 430 440 450
LSVLERLKDQ ADGKYVLVAG ITPTPLGEGK STVTIGLVQA LTAHLNVNSF
460 470 480 490 500
ACLRQPSQGP TFGVKGGAAG GGYAQVIPME EFNLHLTGDI HAITAANNLL
510 520 530 540 550
AAAIDTRILH ENTQTDKALY NRLVPLVNGV REFSEIQLAR LKKLGINKTD
560 570 580 590 600
PSTLTEEEVS KFARLDIDPS TITWQRVLDT NDRFLRKITI GQGNTEKGHY
610 620 630 640 650
RQAQFDIAVA SEIMAVLALT DSLADMKARL GRMVVASDKS GQPVTADDLG
660 670 680 690 700
VTGALTVLMK DAIKPNLMQT LEGTPVFVHA GPFANIAHGN SSVLADKIAL
710 720 730 740 750
KLVGEEGFVV TEAGFGADIG MEKFFNIKCR ASGLVPNVVV LVATVRALKM
760 770 780 790 800
HGGGPSVTAG VPLKKEYTEE NIQLVADGCC NLQKQIQITQ LFGVPVVVAL
810 820 830 840 850
NVFKTDTRAE IDLVCELAKR AGAFDAVPCY HWSVGGKGSV DLARAVREAA
860 870 880 890 900
SKRSRFQFLY DVQVPIVDKI RTIAQAVYGA KDIELSPEAQ AKIDRYTQQG
910 920 930 940 950
FGNLPICMAK THLSLSHQPD KKGVPRDFIL PISDVRASIG AGFIYPLVGT
960 970
MSTMPGLPTR PCFYDIDLDT ETEQVKGLF
Length:979
Mass (Da):105,889
Last modified:March 3, 2009 - v1
Checksum:iD5BB0E871BC20444
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035086 Genomic DNA. No translation available.
AL049694 Genomic DNA. No translation available.
AL133260 Genomic DNA. No translation available.
KF458323 Genomic DNA. No translation available.
BC136685 mRNA. Translation: AAI36686.1.
BC144368 mRNA. Translation: AAI44369.1.
RefSeqiNP_001229696.1. NM_001242767.1.
XP_016866191.1. XM_017010702.1.
XP_016866192.1. XM_017010703.1.
UniGeneiHs.591343.

Genome annotation databases

EnsembliENST00000611279; ENSP00000478253; ENSG00000120254.
GeneIDi25902.
UCSCiuc021zgs.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035086 Genomic DNA. No translation available.
AL049694 Genomic DNA. No translation available.
AL133260 Genomic DNA. No translation available.
KF458323 Genomic DNA. No translation available.
BC136685 mRNA. Translation: AAI36686.1.
BC144368 mRNA. Translation: AAI44369.1.
RefSeqiNP_001229696.1. NM_001242767.1.
XP_016866191.1. XM_017010702.1.
XP_016866192.1. XM_017010703.1.
UniGeneiHs.591343.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000356290.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611279; ENSP00000478253; ENSG00000120254.
GeneIDi25902.
UCSCiuc021zgs.2. human.

Organism-specific databases

CTDi25902.
HGNCiHGNC:21055. MTHFD1L.
OpenTargetsiENSG00000120254.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4230. Eukaryota.
COG0190. LUCA.
COG2759. LUCA.
GeneTreeiENSGT00860000133777.
HOGENOMiHOG000040280.
HOVERGENiHBG004916.
OMAiCSHDFLS.
OrthoDBiEOG091G01BU.

Miscellaneous databases

ChiTaRSiMTHFD1L. human.
GenomeRNAii25902.

Gene expression databases

BgeeiENSG00000120254.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
Gene3Di3.40.50.300. 2 hits.
3.40.50.720. 2 hits.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR016040. NAD(P)-bd_dom.
IPR027417. P-loop_NTPase.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
PF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7ZM99_HUMAN
AccessioniPrimary (citable) accession number: B7ZM99
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.