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Protein

Phosphoinositide phospholipase C

Gene

PLCE1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:PLCE1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiB7ZM61.
PeptideAtlasiB7ZM61.
PRIDEiB7ZM61.

Expressioni

Gene expression databases

BgeeiENSG00000138193.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000260766.

Structurei

3D structure databases

ProteinModelPortaliB7ZM61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini531 – 790Ras-GEFInterPro annotationAdd BLAST260
Domaini1376 – 1524PI-PLC X-boxInterPro annotationAdd BLAST149
Domaini1739 – 1829PI-PLC Y-boxInterPro annotationAdd BLAST91
Domaini1844 – 1928C2InterPro annotationAdd BLAST85
Domaini2119 – 2222Ras-associatingInterPro annotationAdd BLAST104

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
HOVERGENiHBG059220.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.840.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 3 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR028398. PLC-epsilon1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000159. RA_dom.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 3 hits.
PTHR10336:SF6. PTHR10336:SF6. 3 hits.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48366. SSF48366. 3 hits.
SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 3 hits.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZM61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEEMTASV LIPVTQRKVV SAQSAADESS EKVSDINISK AHTVRRSGET
60 70 80 90 100
SHTISQLNKL KEEPSGSNLP KILSIAREKI VSDENSNEKC WEKIMPDSAK
110 120 130 140 150
NLNINCNNIL RNHQHGLPQR QFYEMYNSVA EEDLCLETGI PSPLERKVFP
160 170 180 190 200
GIQLELDRPS MGISPLGNQS VIIETGRAHP DSRRAVFHFH YEVDRRMSDT
210 220 230 240 250
FCTLSENLIL DDCGNCVPLP GGEEKQKKNY VAYTCKLMEL AKNCDNKNEQ
260 270 280 290 300
LQCDHCDTLN DKYFCFEGSC EKVDMVYSGD SFCRKDFTDS QAAKTFLSHF
310 320 330 340 350
EDFPDNCDDV EEDAFKSKKE RSTLLVRRFC KNDREVKKSV YTGTRAIVRT
360 370 380 390 400
LPSGHIGLTA WSYIDQKRNG PLLPCGRVME PPSTVEIRQD GSQRLSEAQW
410 420 430 440 450
YPIYNAVRRE ETENTVGSLL HFLTKLPASE TAHGRISVGP CLKQCVRDTV
460 470 480 490 500
CEYRATLQRT SISQYITGSL LEATTSLGAR SGLLSTFGGS TGRMMLKERQ
510 520 530 540 550
PGPSVANSNA LPSSSAGISK ELIDLQPLIQ FPEEVASILM EQEQTIYRRV
560 570 580 590 600
LPVDYLCFLT RDLGTPECQS SLPCLKASIS ASILTTQNGE HNALEDLVMR
610 620 630 640 650
FNEVSSWVTW LILTAGSMEE KREVFSYLVH VAKCCWNMGN YNAVMEFLAG
660 670 680 690 700
LRSRKVLKMW QFMDQSDIET MRSLKDAMAQ HESSCEYRKV VTRALHIPGC
710 720 730 740 750
KVVPFCGVFL KELCEVLDGA SGLMKLCPRY NSQEETLEFV ADYSGQDNFL
760 770 780 790 800
QRVGQNGLKN SEKESTVNSI FQVIRSCNRS LETDEEDSPS EGNSSRKSSL
810 820 830 840 850
KDKSRWQFII GDLLDSDNDI FEQSKEYDSH GSEDSQKAFD HGTELIPWYV
860 870 880 890 900
LSIQADVHQF LLQGATVIHY DQDTHLSARC FLQLQPDNST LTWVKPTTAS
910 920 930 940 950
PASSKAKLGV LNNTAEPGKF PLLGNAGLSS LTEGVLDLFA VKAVYMGHPG
960 970 980 990 1000
IDIHTVCVQN KLGSMFLSET GVTLLYGLQT TDNRLLHFVA PKHTAKMLFS
1010 1020 1030 1040 1050
GLLELTRAVR KMRKFPDQRQ QWLRKQYVSL YQEDGRYEGP TLAHAVELFG
1060 1070 1080 1090 1100
GRRWSARNPS PGTSAKNAEK PNMQRNNTLG ISTTKKKKKI LMRGESGEVT
1110 1120 1130 1140 1150
DDEMATRKAK MHKECRSRSG SDPQDINEQE ESEVNAIANP PNPLPSRRAH
1160 1170 1180 1190 1200
SLTTAGSPNL AAGTSSPISA WSSSSWHGRI KGGMKGFQSF MVSDSNMSFV
1210 1220 1230 1240 1250
EFVELFKSFS VRSRKDLKDL FDVYAVPCNR SGSESAPLYT NLTIDENTSD
1260 1270 1280 1290 1300
LQPDLDLLTR NVSDLGLFIK SKQQLSDNQR QISDAIAAAS IVTNGTGIES
1310 1320 1330 1340 1350
TSLGIFGVGI LQLNDFLVNC QGEHCTYDEI LSIIQKFEPS ISMCHQGLMS
1360 1370 1380 1390 1400
FEGFARFLMD KENFASKNDE SQENIKELQL PLSYYYIESS HNTYLTGHQL
1410 1420 1430 1440 1450
KGESSVELYS QVLLQGCRSV ELDCWDGDDG MPIIYHGHTL TTKIPFKEVV
1460 1470 1480 1490 1500
EAIDRSAFIN SDLPIIISIE NHCSLPQQRK MAEIFKTVFG EKLVTKFLFE
1510 1520 1530 1540 1550
TDFSDDPMLP SPDQLRKKVL LKNKKLKAHQ TPVDILKQKA HQLASMQVQA
1560 1570 1580 1590 1600
YNGGNANPRP ANNEEEEDEE DEYDYDYESL SDDNILEDRP ENKSCNDKLQ
1610 1620 1630 1640 1650
FEYNEEIPKR IKKADNSACN KGKVYDMELG EEFYLDQNKK ESRQIAPELS
1660 1670 1680 1690 1700
DLVIYCQAVK FPGLSTLNAS GSSRGKERKS RKSIFGNNPG RMSPGETASF
1710 1720 1730 1740 1750
NKTSGKSSCE GIRQTWEESS SPLNPTTSLS AIIRTPKCYH ISSLNENAAK
1760 1770 1780 1790 1800
RLCRRYSQKL TQHTACQLLR TYPAATRIDS SNPNPLMFWL HGIQLVALNY
1810 1820 1830 1840 1850
QTDDLPLHLN AAMFEANGGC GYVLKPPVLW DKNCPMYQKF SPLERDLDSM
1860 1870 1880 1890 1900
DPAVYSLTIV SGQNVCPSNS MGSPCIEVDV LGMPLDSCHF RTKPIHRNTL
1910 1920 1930 1940 1950
NPMWNEQFLF HVHFEDLVFL RFAVVENNSS AVTAQRIIPL KALKRGYRHL
1960 1970 1980 1990 2000
QLRNLHNEVL EISSLFINSR RMEENSSGNT MSASSMFNTE ERKCLQTHRV
2010 2020 2030 2040 2050
TVHGVPGPEP FTVFTINGGT KAKQLLQQIL TNEQDIKPVT TDYFLMEEKY
2060 2070 2080 2090 2100
FISKEKNECR KQPFQRAIGP EEEIMQILSS WFPEEGYMGR IVLKTQQENL
2110 2120 2130 2140 2150
EEKNIVQDDK EVILSSEEES FFVQVHDVSP EQPRTVIKAP RVSTAQDVIQ
2160 2170 2180 2190 2200
QTLCKAKYSY SILSNPNPSD YVLLEEVVKD TTNKKTTTPK SSQRVLLDQE
2210 2220 2230 2240 2250
CVFQAQSKWK GAGKFILKLK EQVQASREDK KKGISFASEL KKLTKSTKQP
2260 2270 2280
RGLTSPSQLL TSESIQTKEE KPVGGLSSSD TMDYRQ
Length:2,286
Mass (Da):257,104
Last modified:March 3, 2009 - v1
Checksum:i8E7D88B28FA21B0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144286 mRNA. Translation: AAI44287.1.
RefSeqiNP_001275918.1. NM_001288989.1.
UniGeneiHs.655033.

Genome annotation databases

GeneIDi51196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144286 mRNA. Translation: AAI44287.1.
RefSeqiNP_001275918.1. NM_001288989.1.
UniGeneiHs.655033.

3D structure databases

ProteinModelPortaliB7ZM61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000260766.

Proteomic databases

PaxDbiB7ZM61.
PeptideAtlasiB7ZM61.
PRIDEiB7ZM61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi51196.

Organism-specific databases

CTDi51196.

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
HOVERGENiHBG059220.

Miscellaneous databases

ChiTaRSiPLCE1. human.
GenomeRNAii51196.

Gene expression databases

BgeeiENSG00000138193.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.840.10. 2 hits.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 3 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR028398. PLC-epsilon1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000159. RA_dom.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 3 hits.
PTHR10336:SF6. PTHR10336:SF6. 3 hits.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48366. SSF48366. 3 hits.
SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 3 hits.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7ZM61_HUMAN
AccessioniPrimary (citable) accession number: B7ZM61
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.