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Protein
Submitted name:

LTBP1 protein

Gene

LTBP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • microfibril binding Source: AgBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
LTBP1 proteinImported
Gene namesi
Name:LTBP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  • microfibril Source: AgBase
  • protein complex Source: AgBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500286695121 – 1353Sequence analysisAdd BLAST1333

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiB7ZLY3.
PeptideAtlasiB7ZLY3.
PRIDEiB7ZLY3.

Expressioni

Gene expression databases

GenevisibleiB7ZLY3. HS.

Interactioni

Protein-protein interaction databases

IntActiB7ZLY3. 1 interactor.
STRINGi9606.ENSP00000386043.

Structurei

3D structure databases

ProteinModelPortaliB7ZLY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 105EGF-likeInterPro annotationAdd BLAST33
Domaini231 – 276TB (TGF-beta binding)InterPro annotationAdd BLAST46
Domaini300 – 337EGF-likeInterPro annotationAdd BLAST38
Domaini351 – 403TB (TGF-beta binding)InterPro annotationAdd BLAST53
Domaini547 – 584EGF-likeInterPro annotationAdd BLAST38
Domaini589 – 630EGF-likeInterPro annotationAdd BLAST42
Domaini712 – 752EGF-likeInterPro annotationAdd BLAST41
Domaini753 – 793EGF-likeInterPro annotationAdd BLAST41
Domaini794 – 834EGF-likeInterPro annotationAdd BLAST41
Domaini835 – 875EGF-likeInterPro annotationAdd BLAST41
Domaini876 – 917EGF-likeInterPro annotationAdd BLAST42
Domaini979 – 1033TB (TGF-beta binding)InterPro annotationAdd BLAST55
Domaini1099 – 1135EGF-likeInterPro annotationAdd BLAST37
Domaini1156 – 1209TB (TGF-beta binding)InterPro annotationAdd BLAST54
Domaini1253 – 1289EGF-likeInterPro annotationAdd BLAST37
Domaini1294 – 1338EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410Z7XK. LUCA.
HOVERGENiHBG052370.

Family and domain databases

Gene3Di3.90.290.10. 5 hits.
InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR017878. TB_dom.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 12 hits.
PF00683. TB. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 16 hits.
SM00179. EGF_CA. 15 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
SSF57581. SSF57581. 4 hits.
PROSITEiPS00010. ASX_HYDROXYL. 12 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 12 hits.
PS01187. EGF_CA. 14 hits.
PS51364. TB. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZLY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTKLMCLLF FFSLPPLLVS NHTGRIKVVF TPSICKVTCT KGSCQNSCEK
60 70 80 90 100
GNTTTLISEN GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT
110 120 130 140 150
GKLCQIPVHG ASVPKLYQHS QQPGKALGTH VIHSTHTLPL TVTSQQGVKV
160 170 180 190 200
KFPPNIVNIH VKHPPEASVQ IHQVSRIDGP TGQKTKEAQP GQSQVSYQGL
210 220 230 240 250
PVQKTQTIHS TYSHQQVIPH VYPVAAKTQL GRCFQETIGS QCGKALPGLS
260 270 280 290 300
KQEDCCGTVG TSWGFNKCQK CPKKPSYHGY NQMMECLPGY KRVNNTFCQD
310 320 330 340 350
INECQLQGVC PNGECLNTMG SYRCTCKIGF GPDPTFSSCV PDPPVISEEK
360 370 380 390 400
GPCYRLVSSG RQCMHPLSVH LTKQLCCCSV GKAWGPHCEK CPLPGTAAFK
410 420 430 440 450
EICPGGMGYT VSGVHRRRPI HHHVGKGPVF VKPKNTQPVA KSTHPPPLPA
460 470 480 490 500
KEEPVEALTF SREHGPGVAE PEVATAPPEK EIPSLDQEKT KLEPGQPQLS
510 520 530 540 550
PDISTIHLHP QFPVVIEKTS PPVPVEVAPE ASTSSASQVI APTQVTEINE
560 570 580 590 600
CTVNPDICGA GHCINLPVRY TCICYEGYRF SEQQRKCVDI DECTQVQHLC
610 620 630 640 650
SQGRCENTEG SFLCICPAGF MASEEGTNCI DVDECLRPDV CGEGHCVNTV
660 670 680 690 700
GAFRCEYCDS GYRMTQRGRC EDIDECLNPS TCPDEQCVNS PGSYQCVPCT
710 720 730 740 750
EGFRGWNGQC LDVDECLEPN VCANGDCSNL EGSYMCSCHK GYTRTPDHKH
760 770 780 790 800
CRDIDECQQG NLCVNGQCKN TEGSFRCTCG QGYQLSAAKD QCEDIDECQH
810 820 830 840 850
RHLCAHGQCR NTEGSFQCVC DQGYRASGLG DHCEDINECL EDKSVCQRGD
860 870 880 890 900
CINTAGSYDC TCPDGFQLDD NKTCQDINEC EHPGLCGPQG ECLNTEGSFH
910 920 930 940 950
CVCQQGFSIS ADGRTCEDVN ECELLSGVCG EAFCENVEGS FLCVCADENQ
960 970 980 990 1000
EYSPMTGQCR SRTSTDLDVD VDQPKEEKKE CYYNLNDASL CDNVLAPNVT
1010 1020 1030 1040 1050
KQECCCTSGA GWGDNCEIFP CPVLGTAEFT EMCPKGKGFV PAGESSSEAG
1060 1070 1080 1090 1100
GENYKDADEC LLFGQEICKN GFCLNTRPGY ECYCKQGTYY DPVKLQCFDM
1110 1120 1130 1140 1150
DECQDPSSCI DGQCVNTEGS YNCFCTHPMV LDASEKRCIR PAESNEQIEE
1160 1170 1180 1190 1200
TDVYQDLCWE HLSDEYVCSR PLVGKQTTYT ECCCLYGEAW GMQCALCPLK
1210 1220 1230 1240 1250
DSDDYAQLCN IPVTGRRQPY GRDALVDFSE QYTPEADPYF IQDRFLNSFE
1260 1270 1280 1290 1300
ELQAEECGIL NGCENGRCVR VQEGYTCDCF DGYHLDTAKM TCVDVNECDE
1310 1320 1330 1340 1350
LNNRMSLCKN AKCINTDGSY KCLCLPGYVP SDKPNYCTPL NTALNLEKDS

DLE
Length:1,353
Mass (Da):148,464
Last modified:March 3, 2009 - v1
Checksum:i6E6E816C37B74D2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144128 mRNA. Translation: AAI44129.1.
RefSeqiNP_001159736.1. NM_001166264.1.
UniGeneiHs.619315.

Genome annotation databases

GeneIDi4052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144128 mRNA. Translation: AAI44129.1.
RefSeqiNP_001159736.1. NM_001166264.1.
UniGeneiHs.619315.

3D structure databases

ProteinModelPortaliB7ZLY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB7ZLY3. 1 interactor.
STRINGi9606.ENSP00000386043.

Proteomic databases

PaxDbiB7ZLY3.
PeptideAtlasiB7ZLY3.
PRIDEiB7ZLY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4052.

Organism-specific databases

CTDi4052.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410Z7XK. LUCA.
HOVERGENiHBG052370.

Miscellaneous databases

ChiTaRSiLTBP1. human.
GenomeRNAii4052.

Gene expression databases

GenevisibleiB7ZLY3. HS.

Family and domain databases

Gene3Di3.90.290.10. 5 hits.
InterProiIPR026823. cEGF.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR017878. TB_dom.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 12 hits.
PF00683. TB. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 16 hits.
SM00179. EGF_CA. 15 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
SSF57581. SSF57581. 4 hits.
PROSITEiPS00010. ASX_HYDROXYL. 12 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 10 hits.
PS50026. EGF_3. 12 hits.
PS01187. EGF_CA. 14 hits.
PS51364. TB. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7ZLY3_HUMAN
AccessioniPrimary (citable) accession number: B7ZLY3
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.