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Protein
Submitted name:

LTBP1 protein

Gene

LTBP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • microfibril binding Source: AgBase

Names & Taxonomyi

Protein namesi
Submitted name:
LTBP1 proteinImported
Gene namesi
Name:LTBP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500286695121 – 1353Sequence analysisAdd BLAST1333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi77 ↔ 87PROSITE-ProRule annotation
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PeptideAtlasiB7ZLY3
PRIDEiB7ZLY3

Expressioni

Gene expression databases

GenevisibleiB7ZLY3 HS

Interactioni

Protein-protein interaction databases

IntActiB7ZLY3, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliB7ZLY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 105EGF-likeInterPro annotationAdd BLAST33
Domaini231 – 276TBInterPro annotationAdd BLAST46
Domaini300 – 337EGF-likeInterPro annotationAdd BLAST38
Domaini351 – 403TBInterPro annotationAdd BLAST53
Domaini547 – 584EGF-likeInterPro annotationAdd BLAST38
Domaini589 – 630EGF-likeInterPro annotationAdd BLAST42
Domaini712 – 752EGF-likeInterPro annotationAdd BLAST41
Domaini753 – 793EGF-likeInterPro annotationAdd BLAST41
Domaini794 – 834EGF-likeInterPro annotationAdd BLAST41
Domaini835 – 875EGF-likeInterPro annotationAdd BLAST41
Domaini876 – 917EGF-likeInterPro annotationAdd BLAST42
Domaini979 – 1033TBInterPro annotationAdd BLAST55
Domaini1099 – 1135EGF-likeInterPro annotationAdd BLAST37
Domaini1156 – 1209TBInterPro annotationAdd BLAST54
Domaini1253 – 1289EGF-likeInterPro annotationAdd BLAST37
Domaini1294 – 1338EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410Z7XK LUCA
HOVERGENiHBG052370

Family and domain databases

Gene3Di3.90.290.10, 4 hits
InterProiView protein in InterPro
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF12662 cEGF, 1 hit
PF07645 EGF_CA, 12 hits
PF00683 TB, 4 hits
SMARTiView protein in SMART
SM00181 EGF, 16 hits
SM00179 EGF_CA, 15 hits
SUPFAMiSSF57184 SSF57184, 3 hits
SSF57581 SSF57581, 4 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 10 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 7 hits
PS50026 EGF_3, 12 hits
PS01187 EGF_CA, 6 hits
PS51364 TB, 4 hits

Sequencei

Sequence statusi: Complete.

B7ZLY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTKLMCLLF FFSLPPLLVS NHTGRIKVVF TPSICKVTCT KGSCQNSCEK
60 70 80 90 100
GNTTTLISEN GHAADTLTAT NFRVVICHLP CMNGGQCSSR DKCQCPPNFT
110 120 130 140 150
GKLCQIPVHG ASVPKLYQHS QQPGKALGTH VIHSTHTLPL TVTSQQGVKV
160 170 180 190 200
KFPPNIVNIH VKHPPEASVQ IHQVSRIDGP TGQKTKEAQP GQSQVSYQGL
210 220 230 240 250
PVQKTQTIHS TYSHQQVIPH VYPVAAKTQL GRCFQETIGS QCGKALPGLS
260 270 280 290 300
KQEDCCGTVG TSWGFNKCQK CPKKPSYHGY NQMMECLPGY KRVNNTFCQD
310 320 330 340 350
INECQLQGVC PNGECLNTMG SYRCTCKIGF GPDPTFSSCV PDPPVISEEK
360 370 380 390 400
GPCYRLVSSG RQCMHPLSVH LTKQLCCCSV GKAWGPHCEK CPLPGTAAFK
410 420 430 440 450
EICPGGMGYT VSGVHRRRPI HHHVGKGPVF VKPKNTQPVA KSTHPPPLPA
460 470 480 490 500
KEEPVEALTF SREHGPGVAE PEVATAPPEK EIPSLDQEKT KLEPGQPQLS
510 520 530 540 550
PDISTIHLHP QFPVVIEKTS PPVPVEVAPE ASTSSASQVI APTQVTEINE
560 570 580 590 600
CTVNPDICGA GHCINLPVRY TCICYEGYRF SEQQRKCVDI DECTQVQHLC
610 620 630 640 650
SQGRCENTEG SFLCICPAGF MASEEGTNCI DVDECLRPDV CGEGHCVNTV
660 670 680 690 700
GAFRCEYCDS GYRMTQRGRC EDIDECLNPS TCPDEQCVNS PGSYQCVPCT
710 720 730 740 750
EGFRGWNGQC LDVDECLEPN VCANGDCSNL EGSYMCSCHK GYTRTPDHKH
760 770 780 790 800
CRDIDECQQG NLCVNGQCKN TEGSFRCTCG QGYQLSAAKD QCEDIDECQH
810 820 830 840 850
RHLCAHGQCR NTEGSFQCVC DQGYRASGLG DHCEDINECL EDKSVCQRGD
860 870 880 890 900
CINTAGSYDC TCPDGFQLDD NKTCQDINEC EHPGLCGPQG ECLNTEGSFH
910 920 930 940 950
CVCQQGFSIS ADGRTCEDVN ECELLSGVCG EAFCENVEGS FLCVCADENQ
960 970 980 990 1000
EYSPMTGQCR SRTSTDLDVD VDQPKEEKKE CYYNLNDASL CDNVLAPNVT
1010 1020 1030 1040 1050
KQECCCTSGA GWGDNCEIFP CPVLGTAEFT EMCPKGKGFV PAGESSSEAG
1060 1070 1080 1090 1100
GENYKDADEC LLFGQEICKN GFCLNTRPGY ECYCKQGTYY DPVKLQCFDM
1110 1120 1130 1140 1150
DECQDPSSCI DGQCVNTEGS YNCFCTHPMV LDASEKRCIR PAESNEQIEE
1160 1170 1180 1190 1200
TDVYQDLCWE HLSDEYVCSR PLVGKQTTYT ECCCLYGEAW GMQCALCPLK
1210 1220 1230 1240 1250
DSDDYAQLCN IPVTGRRQPY GRDALVDFSE QYTPEADPYF IQDRFLNSFE
1260 1270 1280 1290 1300
ELQAEECGIL NGCENGRCVR VQEGYTCDCF DGYHLDTAKM TCVDVNECDE
1310 1320 1330 1340 1350
LNNRMSLCKN AKCINTDGSY KCLCLPGYVP SDKPNYCTPL NTALNLEKDS

DLE
Length:1,353
Mass (Da):148,464
Last modified:March 3, 2009 - v1
Checksum:i6E6E816C37B74D2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC144128 mRNA Translation: AAI44129.1
RefSeqiNP_001159736.1, NM_001166264.1
UniGeneiHs.619315

Genome annotation databases

GeneIDi4052

Similar proteinsi

Entry informationi

Entry nameiB7ZLY3_HUMAN
AccessioniPrimary (citable) accession number: B7ZLY3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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