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Protein
Submitted name:

FN1 protein

Gene

FN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
FN1 proteinImported
Gene namesi
Name:FN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 22402214Sequence analysisPRO_5002866941Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiB7ZLE5.
PRIDEiB7ZLE5.

Structurei

3D structure databases

ProteinModelPortaliB7ZLE5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiB7ZLE5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 9041Fibronectin type-IInterPro annotationAdd
BLAST
Domaini95 – 13844Fibronectin type-IInterPro annotationAdd
BLAST
Domaini139 – 18244Fibronectin type-IInterPro annotationAdd
BLAST
Domaini184 – 22845Fibronectin type-IInterPro annotationAdd
BLAST
Domaini229 – 27345Fibronectin type-IInterPro annotationAdd
BLAST
Domaini306 – 34540Fibronectin type-IInterPro annotationAdd
BLAST
Domaini355 – 40349Fibronectin type-IIInterPro annotationAdd
BLAST
Domaini415 – 46349Fibronectin type-IIInterPro annotationAdd
BLAST
Domaini468 – 51144Fibronectin type-IInterPro annotationAdd
BLAST
Domaini516 – 55843Fibronectin type-IInterPro annotationAdd
BLAST
Domaini559 – 60244Fibronectin type-IInterPro annotationAdd
BLAST
Domaini610 – 70293Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini722 – 81291Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini813 – 90492Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini909 – 99890Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini999 – 108890Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1089 – 117587Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1176 – 126691Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1269 – 136193Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1362 – 144988Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1450 – 154394Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1544 – 163491Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1635 – 172793Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1728 – 181487Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1815 – 190894Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1959 – 205193Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini2058 – 210245Fibronectin type-IInterPro annotationAdd
BLAST
Domaini2103 – 214543Fibronectin type-IInterPro annotationAdd
BLAST
Domaini2147 – 218741Fibronectin type-IInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000234344.
HOVERGENiHBG005731.
KOiK05717.

Family and domain databases

Gene3Di2.10.10.10. 2 hits.
2.60.40.10. 15 hits.
InterProiIPR000083. Fibronectin_type1.
IPR003961. FN3_dom.
IPR000562. FN_type2_col-bd.
IPR013783. Ig-like_fold.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00039. fn1. 12 hits.
PF00040. fn2. 2 hits.
PF00041. fn3. 15 hits.
[Graphical view]
SMARTiSM00058. FN1. 12 hits.
SM00059. FN2. 2 hits.
SM00060. FN3. 15 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 9 hits.
SSF57440. SSF57440. 2 hits.
PROSITEiPS01253. FN1_1. 12 hits.
PS51091. FN1_2. 12 hits.
PS00023. FN2_1. 2 hits.
PS51092. FN2_2. 2 hits.
PS50853. FN3. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZLE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGPGPGLL LLAVQCLGTA VPSTGASKSK RQAQQMVQPQ SPVAVSQSKP
60 70 80 90 100
GCYDNGKHYQ INQQWERTYL GNALVCTCYG GSRGFNCESK PEAEETCFDK
110 120 130 140 150
YTGNTYRVGD TYERPKDSMI WDCTCIGAGR GRISCTIANR CHEGGQSYKI
160 170 180 190 200
GDTWRRPHET GGYMLECVCL GNGKGEWTCK PIAEKCFDHA AGTSYVVGET
210 220 230 240 250
WEKPYQGWMM VDCTCLGEGS GRITCTSRNR CNDQDTRTSY RIGDTWSKKD
260 270 280 290 300
NRGNLLQCIC TGNGRGEWKC ERHTSVQTTS SGSGPFTDVR AAVYQPQPHP
310 320 330 340 350
QPPPYGHCVT DSGVVYSVGM QWLKTQGNKQ MLCTCLGNGV SCQETAVTQT
360 370 380 390 400
YGGNSNGEPC VLPFTYNGRT FYSCTTEGRQ DGHLWCSTTS NYEQDQKYSF
410 420 430 440 450
CTDHTVLVQT RGGNSNGALC HFPFLYNNHN YTDCTSEGRR DNMKWCGTTQ
460 470 480 490 500
NYDADQKFGF CPMAAHEEIC TTNEGVMYRI GDQWDKQHDM GHMMRCTCVG
510 520 530 540 550
NGRGEWTCIA YSQLRDQCIV DDITYNVNDT FHKRHEEGHM LNCTCFGQGR
560 570 580 590 600
GRWKCDPVDQ CQDSETGTFY QIGDSWEKYV HGVRYQCYCY GRGIGEWHCQ
610 620 630 640 650
PLQTYPSSSG PVEVFITETP SQPNSHPIQW NAPQPSHISK YILRWRPKNS
660 670 680 690 700
VGRWKEATIP GHLNSYTIKG LKPGVVYEGQ LISIQQYGHQ EVTRFDFTTT
710 720 730 740 750
STSTPVTSNT VTGETTPFSP LVATSESVTE ITASSFVVSW VSASDTVSGF
760 770 780 790 800
RVEYELSEEG DEPQYLDLPS TATSVNIPDL LPGRKYIVNV YQISEDGEQS
810 820 830 840 850
LILSTSQTTA PDAPPDPTVD QVDDTSIVVR WSRPQAPITG YRIVYSPSVE
860 870 880 890 900
GSSTELNLPE TANSVTLSDL QPGVQYNITI YAVEENQEST PVVIQQETTG
910 920 930 940 950
TPRSDTVPSP RDLQFVEVTD VKVTIMWTPP ESAVTGYRVD VIPVNLPGEH
960 970 980 990 1000
GQRLPISRNT FAEVTGLSPG VTYYFKVFAV SHGRESKPLT AQQTTKLDAP
1010 1020 1030 1040 1050
TNLQFVNETD STVLVRWTPP RAQITGYRLT VGLTRRGQPR QYNVGPSVSK
1060 1070 1080 1090 1100
YPLRNLQPAS EYTVSLVAIK GNQESPKATG VFTTLQPGSS IPPYNTEVTE
1110 1120 1130 1140 1150
TTIVITWTPA PRIGFKLGVR PSQGGEAPRE VTSDSGSIVV SGLTPGVEYV
1160 1170 1180 1190 1200
YTIQVLRDGQ ERDAPIVNKV VTPLSPPTNL HLEANPDTGV LTVSWERSTT
1210 1220 1230 1240 1250
PDITGYRITT TPTNGQQGNS LEEVVHADQS SCTFDNLSPG LEYNVSVYTV
1260 1270 1280 1290 1300
KDDKESVPIS DTIIPAVPPP TDLRFTNIGP DTMRVTWAPP PSIDLTNFLV
1310 1320 1330 1340 1350
RYSPVKNEED VAELSISPSD NAVVLTNLLP GTEYVVSVSS VYEQHESTPL
1360 1370 1380 1390 1400
RGRQKTGLDS PTGIDFSDIT ANSFTVHWIA PRATITGYRI RHHPEHFSGR
1410 1420 1430 1440 1450
PREDRVPHSR NSITLTNLTP GTEYVVSIVA LNGREESPLL IGQQSTVSDV
1460 1470 1480 1490 1500
PRDLEVVAAT PTSLLISWDA PAVTVRYYRI TYGETGGNSP VQEFTVPGSK
1510 1520 1530 1540 1550
STATISGLKP GVDYTITVYA VTGRGDSPAS SKPISINYRT EIDKPSQMQV
1560 1570 1580 1590 1600
TDVQDNSISV KWLPSSSPVT GYRVTTTPKN GPGPTKTKTA GPDQTEMTIE
1610 1620 1630 1640 1650
GLQPTVEYVV SVYAQNPSGE SQPLVQTAVT TIPAPTDLKF TQVTPTSLSA
1660 1670 1680 1690 1700
QWTPPNVQLT GYRVRVTPKE KTGPMKEINL APDSSSVVVS GLMVATKYEV
1710 1720 1730 1740 1750
SVYALKDTLT SRPAQGVVTT LENVSPPRRA RVTDATETTI TISWRTKTET
1760 1770 1780 1790 1800
ITGFQVDAVP ANGQTPIQRT IKPDVRSYTI TGLQPGTDYK IYLYTLNDNA
1810 1820 1830 1840 1850
RSSPVVIDAS TAIDAPSNLR FLATTPNSLL VSWQPPRARI TGYIIKYEKP
1860 1870 1880 1890 1900
GSPPREVVPR PRPGVTEATI TGLEPGTEYT IYVIALKNNQ KSEPLIGRKK
1910 1920 1930 1940 1950
TVQKTPFVTH PGYDTGNGIQ LPGTSGQQPS VGQQMIFEEH GFRRTTPPTT
1960 1970 1980 1990 2000
ATPIRHRPRP YPPNVGQEAL SQTTISWAPF QDTSEYIISC HPVGTDEEPL
2010 2020 2030 2040 2050
QFRVPGTSTS ATLTGLTRGA TYNIIVEALK DQQRHKVREE VVTVGNSVNE
2060 2070 2080 2090 2100
GLNQPTDDSC FDPYTVSHYA VGDEWERMSE SGFKLLCQCL GFGSGHFRCD
2110 2120 2130 2140 2150
SSRWCHDNGV NYKIGEKWDR QGENGQMMSC TCLGNGKGEF KCDPHEATCY
2160 2170 2180 2190 2200
DDGKTYHVGE QWQKEYLGAI CSCTCFGGQR GWRCDNCRRP GGEPSPEGTT
2210 2220 2230 2240
GQSYNQYSQR YHQRTNTNVN CPIECFMPLD VQADREDSRE
Length:2,240
Mass (Da):246,698
Last modified:March 3, 2009 - v1
Checksum:iCC54406F703599CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC143754 mRNA. Translation: AAI43755.1.
RefSeqiNP_001293058.1. NM_001306129.1.
NP_001293059.1. NM_001306130.1.
NP_001293061.1. NM_001306132.1.
UniGeneiHs.203717.

Genome annotation databases

GeneIDi2335.
KEGGihsa:2335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC143754 mRNA. Translation: AAI43755.1.
RefSeqiNP_001293058.1. NM_001306129.1.
NP_001293059.1. NM_001306130.1.
NP_001293061.1. NM_001306132.1.
UniGeneiHs.203717.

3D structure databases

ProteinModelPortaliB7ZLE5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiB7ZLE5.
PRIDEiB7ZLE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2335.
KEGGihsa:2335.

Organism-specific databases

CTDi2335.

Phylogenomic databases

HOGENOMiHOG000234344.
HOVERGENiHBG005731.
KOiK05717.

Miscellaneous databases

ChiTaRSiFN1. human.
EvolutionaryTraceiB7ZLE5.
GenomeRNAii2335.

Family and domain databases

Gene3Di2.10.10.10. 2 hits.
2.60.40.10. 15 hits.
InterProiIPR000083. Fibronectin_type1.
IPR003961. FN3_dom.
IPR000562. FN_type2_col-bd.
IPR013783. Ig-like_fold.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00039. fn1. 12 hits.
PF00040. fn2. 2 hits.
PF00041. fn3. 15 hits.
[Graphical view]
SMARTiSM00058. FN1. 12 hits.
SM00059. FN2. 2 hits.
SM00060. FN3. 15 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 9 hits.
SSF57440. SSF57440. 2 hits.
PROSITEiPS01253. FN1_1. 12 hits.
PS51091. FN1_2. 12 hits.
PS00023. FN2_1. 2 hits.
PS51092. FN2_2. 2 hits.
PS50853. FN3. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: CerebellumImported.

Entry informationi

Entry nameiB7ZLE5_HUMAN
AccessioniPrimary (citable) accession number: B7ZLE5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 6, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.