Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

ITIH4 protein

Gene

ITIH4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ITIH4 proteinImported
Submitted name:
Inter-alpha-trypsin inhibitor heavy chain H4Imported
Gene namesi
Name:ITIH4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:6169. ITIH4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 935907Sequence analysisPRO_5007644979Add
BLAST

Proteomic databases

EPDiB7ZKJ8.
PeptideAtlasiB7ZKJ8.

Expressioni

Gene expression databases

BgeeiENSG00000055955.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266041.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 148130VITInterPro annotationAdd
BLAST
Domaini274 – 457184VWFAInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOGENOMiHOG000000680.
HOVERGENiHBG057734.
OMAiKGSEMVV.
OrthoDBiEOG091G01HF.
PhylomeDBiB7ZKJ8.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZKJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPRPVRTC SKVLVLLSLL AIHQTTTAEK NGIDIYSLTV DSRVSSRFAH
60 70 80 90 100
TVVTSRVVNR ANTVQEATFQ MELPKKAFIT NFSMIIDGMT YPGIIKEKAE
110 120 130 140 150
AQAQYSAAVA KGKSAGLVKA TGRNMEQFQV SVSVAPNAKI TFELVYEELL
160 170 180 190 200
KRRLGVYELL LKVRPQQLVK HLQMDIHIFE PQGISFLETE STFMTNQLVD
210 220 230 240 250
ALTTWQNKTK AHIRFKPTLS QQQKSPEQQE TVLDGNLIIR YDVDRAISGG
260 270 280 290 300
SIQIENGYFV HYFAPEGLTT MPKNVVFVID KSGSMSGRKI QQTREALIKI
310 320 330 340 350
LDDLSPRDQF NLIVFSTEAT QWRPSLVPAS AENVNKARSF AAGIQALGGT
360 370 380 390 400
NINDAMLMAV QLLDSSNQEE RLPEGSVSLI ILLTDGDPTV GETNPRSIQN
410 420 430 440 450
NVREAVSGRY SLFCLGFGFD VSYAFLEKLA LDNGGLARRI HEDSDSALQL
460 470 480 490 500
QDFYQEVANP LLTAVTFEYP SNAVEEVTQN NFRLLFKGSE MVVAGKLQDR
510 520 530 540 550
GPDVLTATVS GKLPTQNITF QTESSVAEQE AEFQSPKYIF HNFMERLWAY
560 570 580 590 600
LTIQQLLEQT VSASDADQQA LRNQALNLSL AYSFVTPLTS MVVTKPDDQE
610 620 630 640 650
QSQVAEKPME GESRNRNVHS GSTFFKYYLQ GAKIPKPGLD HTEASFSPRR
660 670 680 690 700
GWNRQAGAAG SRMNFRPGVL SSRQLGLPGP PDVPDHAAYH PFRRLAILPA
710 720 730 740 750
SAPPATSNPD PAVSRVMNMK IEETTMTTQT PAPIQAPSAI LPLPGQSVER
760 770 780 790 800
LCVDPRHRQG PVNLLSDPEQ GVEVTGQYER EKAGFSWIEV TFKNPLVWVH
810 820 830 840 850
ASPEHVVVTR NRRSSAYKWK ETLFSVMPGL KMTMDKTGLL LLSDPDKVTI
860 870 880 890 900
GLLFWDGRGE GLRLLLRDTD RFSSHVGGTL GQFYQEVLWG SPAASDDGRR
910 920 930
TLRVQGNDHS ATRERRLDYQ EGPPGVEISC WSVEL
Length:935
Mass (Da):103,881
Last modified:March 3, 2009 - v1
Checksum:i88A1DEA331DB8BEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006254 Genomic DNA. No translation available.
AC099667 Genomic DNA. No translation available.
KC876888 Genomic DNA. No translation available.
BC136392 mRNA. Translation: AAI36393.1.
RefSeqiNP_001159921.1. NM_001166449.1.
NP_002209.2. NM_002218.4.
UniGeneiHs.709406.

Genome annotation databases

EnsembliENST00000485816; ENSP00000417824; ENSG00000055955.
GeneIDi3700.
KEGGihsa:3700.
UCSCiuc011bem.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006254 Genomic DNA. No translation available.
AC099667 Genomic DNA. No translation available.
KC876888 Genomic DNA. No translation available.
BC136392 mRNA. Translation: AAI36393.1.
RefSeqiNP_001159921.1. NM_001166449.1.
NP_002209.2. NM_002218.4.
UniGeneiHs.709406.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000266041.

Proteomic databases

EPDiB7ZKJ8.
PeptideAtlasiB7ZKJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000485816; ENSP00000417824; ENSG00000055955.
GeneIDi3700.
KEGGihsa:3700.
UCSCiuc011bem.3. human.

Organism-specific databases

CTDi3700.
HGNCiHGNC:6169. ITIH4.
PharmGKBiPA29967.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEJB. Eukaryota.
COG2304. LUCA.
GeneTreeiENSGT00550000074468.
HOGENOMiHOG000000680.
HOVERGENiHBG057734.
OMAiKGSEMVV.
OrthoDBiEOG091G01HF.
PhylomeDBiB7ZKJ8.

Miscellaneous databases

ChiTaRSiITIH4. human.
GenomeRNAii3700.

Gene expression databases

BgeeiENSG00000055955.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR010600. ITI_HC_C.
IPR013694. VIT.
IPR002035. VWF_A.
[Graphical view]
PfamiPF06668. ITI_HC_C. 1 hit.
PF08487. VIT. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
SMARTiSM00609. VIT. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS51468. VIT. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7ZKJ8_HUMAN
AccessioniPrimary (citable) accession number: B7ZKJ8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.