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Protein

Histone deacetylase

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi688 – 6881ZincUniRule annotation
Metal bindingi690 – 6901ZincUniRule annotation
Metal bindingi696 – 6961ZincUniRule annotation
Metal bindingi773 – 7731ZincUniRule annotation
Active sitei825 – 8251UniRule annotation
Sitei998 – 9981Contributes to catalysisUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:Hdac5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1333784. Hdac5.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiB7ZDF7.
PaxDbiB7ZDF7.

Expressioni

Gene expression databases

BgeeiB7ZDF7.
ExpressionAtlasiB7ZDF7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102770.

Structurei

3D structure databases

ProteinModelPortaliB7ZDF7.
SMRiB7ZDF7. Positions 673-1053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 15589HDAC4_GlnInterPro annotationAdd
BLAST
Domaini696 – 1014319Hist_deacetylInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili117 – 16852Sequence analysisAdd
BLAST
Coiled coili567 – 59731Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000232065.
HOVERGENiHBG057100.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
IPR030703. Histone_deacetylase_5.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 2 hits.
PTHR10625:SF57. PTHR10625:SF57. 2 hits.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

B7ZDF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPNESDGM SGREPSLEIL PRTPLHSIPV AVEVKPVLPG AMPSSMGGGG
60 70 80 90 100
GGSPSPVELR GALAGPMDPA LREQQLQQEL LVLKQQQQLQ KQLLFAEFQK
110 120 130 140 150
QHDHLTRQHE VQLQKHLKQQ QEMLAAKRQQ ELEQQRQREQ QRQEELEKQR
160 170 180 190 200
LEQQLLILRN KEKSKESAIA STEVKLRLQE FLLSKSKEPT PGGLNHSLPQ
210 220 230 240 250
HPKCWGAHHA SLDQSSPPQS GPPGTPPSYK LPLLGPYDSR DDFPLRKTAS
260 270 280 290 300
EPNLKVRSRL KQKVAERRSS PLLRRKDGTV ISTFKKRAVE ITGTGPGVSS
310 320 330 340 350
VCNSAPGSGP SSPNSSHSTI AENGFTGSVP NIPTEMIPQH RALPLDSSPN
360 370 380 390 400
QFSLYTSPSL PNISLGLQAT VTVTNSHLTA SPKLSTQQEA ERQALQSLRQ
410 420 430 440 450
GGTLTGKFMS TSSIPGCLLG VALEGDTSPH GHASLLQHVL LLEQARQQST
460 470 480 490 500
LIAVPLHGQS PLVTGERVAT SMRTVGKLPR HRPLSRTQSS PLPQSPQALQ
510 520 530 540 550
QLVMQQQHQQ FLEKQKQQQM QLGKILTKTG ELSRQPTTHP EETEEELTEQ
560 570 580 590 600
QEALLGEGAL TIPREGSTES ESTQEDLEEE EEEEEEEEED CIQVKDEDGE
610 620 630 640 650
SGPDEGPDLE ESSAGYKKLF ADAQQLQPLQ VYQAPLSLAT VPHQALGRTQ
660 670 680 690 700
SSPAAPGSMK SPTDQPTVVK HLFTTGVVYD TFMLKHQCMC GNTHVHPEHA
710 720 730 740 750
GRIQSIWSRL QETGLLGKCE RIRGRKATLD EIQTVHSEYH TLLYGTSPLN
760 770 780 790 800
RQKLDSKKLL GPISQKMYAM LPCGGIGVDS DTVWNEMHSS SAVRMAVGCL
810 820 830 840 850
VELAFKVAAG ELKNGFAIIR PPGHHAEEST AMGFCFFNSV AITAKLLQQK
860 870 880 890 900
LSVGKVLIVD WDIHHGNGTQ QAFYNDPSVL YISLHRYDNG NFFPGSGAPE
910 920 930 940 950
EVGGGPGVGY NVNVAWTGGV DPPIGDVEYL TAFRTVVMPI AQEFSPDVVL
960 970 980 990 1000
VSAGFDAVEG HLSPLGGYSV TARCFGHLTR QLMTLAGGRV VLALEGGHDL
1010 1020 1030 1040 1050
TAICDASEAC VSALLSVELQ PLDEAVLQQK PSVNAVATLE KVIEIQSKHW
1060 1070 1080 1090 1100
SCVQRFAAGL GCSLREAQTG EKEEAETVSA MALLSVGAEQ AQAVATQEHS

PR
Length:1,102
Mass (Da):119,825
Last modified:March 3, 2009 - v1
Checksum:iAB4F26068F2E8240
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954730 Genomic DNA. No translation available.
RefSeqiNP_001271179.1. NM_001284250.1.
UniGeneiMm.22665.

Genome annotation databases

EnsembliENSMUST00000107150; ENSMUSP00000102768; ENSMUSG00000008855.
GeneIDi15184.
UCSCiuc007lqx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954730 Genomic DNA. No translation available.
RefSeqiNP_001271179.1. NM_001284250.1.
UniGeneiMm.22665.

3D structure databases

ProteinModelPortaliB7ZDF7.
SMRiB7ZDF7. Positions 673-1053.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102770.

Proteomic databases

MaxQBiB7ZDF7.
PaxDbiB7ZDF7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107150; ENSMUSP00000102768; ENSMUSG00000008855.
GeneIDi15184.
UCSCiuc007lqx.1. mouse.

Organism-specific databases

CTDi10014.
MGIiMGI:1333784. Hdac5.

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000232065.
HOVERGENiHBG057100.

Miscellaneous databases

ChiTaRSiHdac5. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiB7ZDF7.
ExpressionAtlasiB7ZDF7. baseline and differential.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
IPR030703. Histone_deacetylase_5.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 2 hits.
PTHR10625:SF57. PTHR10625:SF57. 2 hits.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB7ZDF7_MOUSE
AccessioniPrimary (citable) accession number: B7ZDF7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 8, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.