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Protein

Histone deacetylase

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi707ZincUniRule annotation1
Metal bindingi709ZincUniRule annotation1
Metal bindingi715ZincUniRule annotation1
Metal bindingi792ZincUniRule annotation1
Active sitei844UniRule annotation1
Sitei1017Contributes to catalysisUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:Hdac5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1333784. Hdac5.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

MaxQBiB7ZDF5.
PaxDbiB7ZDF5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008855.
ExpressionAtlasiB7ZDF5. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB7ZDF5.
SMRiB7ZDF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 174HDAC4_GlnInterPro annotationAdd BLAST89
Domaini715 – 1033Hist_deacetylInterPro annotationAdd BLAST319

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili136 – 187Sequence analysisAdd BLAST52
Coiled coili586 – 616Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000232065.
HOVERGENiHBG057100.
OMAiLGPYDSR.
OrthoDBiEOG091G0EQO.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
IPR030703. Histone_deacetylase_5.
IPR015943. WD40/YVTN_repeat-like_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PTHR10625:SF159. PTHR10625:SF159. 1 hit.
PfamiView protein in Pfam
PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

B7ZDF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLVPKAQGL VEMLQTIYET ESCFSADGMS GREPSLEILP RTPLHSIPVA
60 70 80 90 100
VEVKPVLPGA MPSSMGGGGG GSPSPVELRG ALAGPMDPAL REQQLQQELL
110 120 130 140 150
VLKQQQQLQK QLLFAEFQKQ HDHLTRQHEV QLQKHLKQQQ EMLAAKRQQE
160 170 180 190 200
LEQQRQREQQ RQEELEKQRL EQQLLILRNK EKSKESAIAS TEVKLRLQEF
210 220 230 240 250
LLSKSKEPTP GGLNHSLPQH PKCWGAHHAS LDQSSPPQSG PPGTPPSYKL
260 270 280 290 300
PLLGPYDSRD DFPLRKTASE PNLKVRSRLK QKVAERRSSP LLRRKDGTVI
310 320 330 340 350
STFKKRAVEI TGTGPGVSSV CNSAPGSGPS SPNSSHSTIA ENGFTGSVPN
360 370 380 390 400
IPTEMIPQHR ALPLDSSPNQ FSLYTSPSLP NISLGLQATV TVTNSHLTAS
410 420 430 440 450
PKLSTQQEAE RQALQSLRQG GTLTGKFMST SSIPGCLLGV ALEGDTSPHG
460 470 480 490 500
HASLLQHVLL LEQARQQSTL IAVPLHGQSP LVTGERVATS MRTVGKLPRH
510 520 530 540 550
RPLSRTQSSP LPQSPQALQQ LVMQQQHQQF LEKQKQQQMQ LGKILTKTGE
560 570 580 590 600
LSRQPTTHPE ETEEELTEQQ EALLGEGALT IPREGSTESE STQEDLEEEE
610 620 630 640 650
EEEEEEEEDC IQVKDEDGES GPDEGPDLEE SSAGYKKLFA DAQQLQPLQV
660 670 680 690 700
YQAPLSLATV PHQALGRTQS SPAAPGSMKS PTDQPTVVKH LFTTGVVYDT
710 720 730 740 750
FMLKHQCMCG NTHVHPEHAG RIQSIWSRLQ ETGLLGKCER IRGRKATLDE
760 770 780 790 800
IQTVHSEYHT LLYGTSPLNR QKLDSKKLLG PISQKMYAML PCGGIGVDSD
810 820 830 840 850
TVWNEMHSSS AVRMAVGCLV ELAFKVAAGE LKNGFAIIRP PGHHAEESTA
860 870 880 890 900
MGFCFFNSVA ITAKLLQQKL SVGKVLIVDW DIHHGNGTQQ AFYNDPSVLY
910 920 930 940 950
ISLHRYDNGN FFPGSGAPEE VGGGPGVGYN VNVAWTGGVD PPIGDVEYLT
960 970 980 990 1000
AFRTVVMPIA QEFSPDVVLV SAGFDAVEGH LSPLGGYSVT ARCFGHLTRQ
1010 1020 1030 1040 1050
LMTLAGGRVV LALEGGHDLT AICDASEACV SALLSVELQP LDEAVLQQKP
1060 1070 1080 1090 1100
SVNAVATLEK VIEIQSKHWS CVQRFAAGLG CSLREAQTGE KEEAETVSAM
1110 1120
ALLSVGAEQA QAVATQEHSP R
Length:1,121
Mass (Da):121,950
Last modified:March 3, 2009 - v1
Checksum:iAD2B7FB33C856A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954730 Genomic DNA. No translation available.
RefSeqiNP_001271177.1. NM_001284248.1.
UniGeneiMm.22665.

Genome annotation databases

EnsembliENSMUST00000008999; ENSMUSP00000008999; ENSMUSG00000008855.
GeneIDi15184.
UCSCiuc007lqw.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB7ZDF5_MOUSE
AccessioniPrimary (citable) accession number: B7ZDF5
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 5, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported