Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B7ZCA0 (B7ZCA0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:SYNGAP1 Ensembl ENSP00000416519
OrganismHomo sapiens (Human) [Reference proteome] Ensembl ENSP00000416519
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1279 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains PH domain. SAAS SAAS008936

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000416519

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue12791 Ensembl ENSP00000416519

Sequences

Sequence LengthMass (Da)Tools
B7ZCA0 [UniParc].

Last modified June 26, 2013. Version 2.
Checksum: A08F55516DBCCBDA

FASTA1,279141,325
        10         20         30         40         50         60 
MSRSRASIHR GSIPAMSYAP FRDVRGPSMH RTQYVHSPYD RPGWNPRFCI ISGNQLLMLD 

        70         80         90        100        110        120 
EDEIHPLLIR DRRSESSRNK LLRRTVSVPV EGRPHGEHEY HLGRSRRKSV PGGKQYSMEG 

       130        140        150        160        170        180 
APAAPFRPSQ GFLSRRLKSS IKRTKSQPKL DRTSSFRQIL PRFRSADHDR ARLMQSFKES 

       190        200        210        220        230        240 
HSHESLLSPS SAAEALELNL DEDSIIKPVH SSILGQEFCF EVTTSSGTKC FACRSAAERD 

       250        260        270        280        290        300 
KWIENLQRAV KPNKDNSRRV DNVLKLWIIE ARELPPKKRY YCELCLDDML YARTTSKPRS 

       310        320        330        340        350        360 
ASGDTVFWGE HFEFNNLPAV RALRLHLYRD SDKKRKKDKA GYVGLVTVPV ATLAGRHFTE 

       370        380        390        400        410        420 
QWYPVTLPTG SGGSGGMGSG GGGGSGGGSG GKGKGGCPAV RLKARYQTMS ILPMELYKEF 

       430        440        450        460        470        480 
AEYVTNHYRM LCAVLEPALN VKGKEEVASA LVHILQSTGK AKDFLSDMAM SEVDRFMERE 

       490        500        510        520        530        540 
HLIFRENTLA TKAIEEYMRL IGQKYLKDAI GEFIRALYES EENCEVDPIK CTASSLAEHQ 

       550        560        570        580        590        600 
ANLRMCCELA LCKVVNSHCV FPRELKEVFA SWRLRCAERG REDIADRLIS ASLFLRFLCP 

       610        620        630        640        650        660 
AIMSPSLFGL MQEYPDEQTS RTLTLIAKVI QNLANFSKFT SKEDFLGFMN EFLELEWGSM 

       670        680        690        700        710        720 
QQFLYEISNL DTLTNSSSFE GYIDLGRELS TLHALLWEVL PQLSKEALLK LGPLPRLLND 

       730        740        750        760        770        780 
ISTALRNPNI QRQPSRQSER PRPQPVVLRG PSAEMQGYMM RDLNSSMDMA RLPSPTKEKP 

       790        800        810        820        830        840 
PPPPPGGGKD LFYVSRPPLA RSSPAYCTSS SDITEPEQKM LSVNKSVSML DLQGDGPGGR 

       850        860        870        880        890        900 
LNSSSVSNLA AVGDLLHSSQ ASLTAALGLR PAPAGRLSQG SGSSITAAGM RLSQMGVTTD 

       910        920        930        940        950        960 
GVPAQQLRIP LSFQNPLFHM AADGPGPPGG HGGGGGHGPP SSHHHHHHHH HHRGGEPPGD 

       970        980        990       1000       1010       1020 
TFAPFHGYSK SEDLSSGVPK PPAASILHSH SYSDEFGPSG TDFTRRQLSL QDNLQHMLSP 

      1030       1040       1050       1060       1070       1080 
PQITIGPQRP APSGPGGGSG GGSGGGGGGQ PPPLQRGKSQ QLTVSAAQKP RPSSGNLLQS 

      1090       1100       1110       1120       1130       1140 
PEPSYGPARP RQQSLSKEGS IGGSGGSGGG GGGGLKPSIT KQHSQTPSTL NPTMPASERT 

      1150       1160       1170       1180       1190       1200 
VAWVSNMPHL SADIESAHIE REEYKLKEYS KSMDESRLDR EYEEEIHSLK ERLHMSNRKL 

      1210       1220       1230       1240       1250       1260 
EEYERRLLSQ EEQTSKILMQ YQARLEQSEK RLRQQQAEKD SQIKSIIGRL MLVEEELRRD 

      1270 
HPAMAEPLPE PKKRLLDAQ 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL662799 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalB7ZCA0.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbB7ZCA0.
PRIDEB7ZCA0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000449372; ENSP00000416519; ENSG00000197283.
UCSCuc010juy.4. human.

Organism-specific databases

HGNCHGNC:11497. SYNGAP1.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245428.
HOGENOMHOG000231979.
HOVERGENHBG006492.
OrthoDBEOG74XS5P.

Gene expression databases

ArrayExpressB7ZCA0.
BgeeB7ZCA0.

Family and domain databases

Gene3D1.10.506.10. 1 hit.
2.20.170.10. 1 hit.
2.30.29.30. 2 hits.
2.60.40.150. 1 hit.
InterProIPR000008. C2_dom.
IPR021887. DUF3498.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
IPR001936. RasGAP.
IPR023152. RasGAP_CS.
IPR008936. Rho_GTPase_activation_prot.
IPR023315. SynGAP_C2_N.
[Graphical view]
PfamPF00168. C2. 1 hit.
PF12004. DUF3498. 1 hit.
PF00616. RasGAP. 1 hit.
[Graphical view]
SMARTSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEPS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35481118.

Entry information

Entry nameB7ZCA0_HUMAN
AccessionPrimary (citable) accession number: B7ZCA0
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: June 26, 2013
Last modified: April 16, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.