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Protein

Kinesin-like protein KIF28P

Gene

KIF28P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Microtubule-dependent motor protein required for mitochondrion morhology and transport of mitochondria in neuronal cells.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi111 – 1188ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF28P
Alternative name(s):
Kinesin-like protein 6
Gene namesi
Name:KIF28P
Synonyms:KLP6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:49205. KIF28P.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 967967Kinesin-like protein KIF28PPRO_0000415569Add
BLAST

Proteomic databases

PRIDEiB7ZC32.

Expressioni

Gene expression databases

BgeeiB7ZC32.

Structurei

3D structure databases

ProteinModelPortaliB7ZC32.
SMRiB7ZC32. Positions 8-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 355349Kinesin motorPROSITE-ProRule annotationAdd
BLAST
Domaini410 – 47263FHAAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili822 – 85130Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 FHA domain.Curated
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000200518.
InParanoidiB7ZC32.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR022140. Kinesin-like_KIF1-typ.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 4 hits.
PfamiPF12423. KIF1B. 1 hit.
PF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZC32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTQSVDSVK AVRVRPFSQR EKNSGSKCVI SMHSRTTTTT QDPKNPEHVK
60 70 80 90 100
TFTFDLAYWS HNGFQRDKDG VLISADPSRK FAGQRDVFHD LGRGILDSAW
110 120 130 140 150
QGYNATLLAY GQTGSGKSYS MIGFGCKQGI IPTVCEELFR AIENQGRNQE
160 170 180 190 200
HQVMFSMLEI YKEIIRDLLS RTKKPGGLRI REDQQLGFYV EGLKSVPCEN
210 220 230 240 250
YAQIERLMEQ GTKIRTTAST NMNASSSRSH LVITIQFKQV FLDRDLTKQS
260 270 280 290 300
SINLVDLARS ERQKSSGSEG DRLREGSCVN LSLTNLGSVI SVLADAAMGK
310 320 330 340 350
KVLHIPYRDS VLTKLLQSAL GGNSRTALVA AVSPADICYE ETLSTLRYAE
360 370 380 390 400
RERKIRNRAV ANTWTLMRKS RAENSKLLPM MTFPHLLNLS EDPQLTRVLK
410 420 430 440 450
YFIQAGTQPA PCPRPALSPP HPALRISDKH ASFTNADGKV TVTPHSKCKV
460 470 480 490 500
AVNGVPITTR TKLQHLDRLI LGSNSTYLYV GFPSEWGSED LSRFDYDFFQ
510 520 530 540 550
LERAAAEGAS ADKLGAADGG DGKAGPSVLA AFQDYIKLMP LVSEANQMSE
560 570 580 590 600
EPKKGLNMEL KVKNLASSDS RGYDLQKEVL VKVTHHGSHE VWIWSKAKFI
610 620 630 640 650
NRKFLMQELY QRFLDGDHGP VARDDDPFWD PVEVVRLGSA HIWLQSLAYC
660 670 680 690 700
MKLEEQVEFL NCDGLEEAVL HTCIAPCSPT GQTHGEEDVV IDPLELLGKR
710 720 730 740 750
MDFQIHIVRC LGVNWMKEDA KRGTQIGYRI YDLPNTIYTK PVWKSVNPQI
760 770 780 790 800
EETVQFAALT ASQEFLNYLR TNALIVDLWG LQEGCTELSC SQLGLMVTGE
810 820 830 840 850
GHILVDTKKI STVKDISQAA SNQIPELYLK LLKLEQETEP LRNINRALRE
860 870 880 890 900
ENVLLKASLA KTASGQAPKP SNTLKISGMT AQLPSAGEMS QMCTQQAGSD
910 920 930 940 950
RELAKALKVF YQSMNTARGQ LFRLRRHQPP EVDQMLRPFI HQRSQMFKDL
960
GDLRESSLWT LKMTLLL
Length:967
Mass (Da):108,254
Last modified:February 22, 2012 - v2
Checksum:iD87C3E911441DDE6
GO

Sequence cautioni

The sequence CAX12164.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113174 Genomic DNA. No translation available.
AL591848 Genomic DNA. Translation: CAX12164.1. Sequence problems.
UniGeneiHs.739045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113174 Genomic DNA. No translation available.
AL591848 Genomic DNA. Translation: CAX12164.1. Sequence problems.
UniGeneiHs.739045.

3D structure databases

ProteinModelPortaliB7ZC32.
SMRiB7ZC32. Positions 8-392.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB7ZC32.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiKIF28P.
HGNCiHGNC:49205. KIF28P.
neXtProtiNX_B7ZC32.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000200518.
InParanoidiB7ZC32.

Miscellaneous databases

PROiB7ZC32.

Gene expression databases

BgeeiB7ZC32.

Family and domain databases

Gene3Di2.60.200.20. 1 hit.
3.40.850.10. 1 hit.
InterProiIPR000253. FHA_dom.
IPR027640. Kinesin-like_fam.
IPR022140. Kinesin-like_KIF1-typ.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 4 hits.
PfamiPF12423. KIF1B. 1 hit.
PF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKIF28_HUMAN
AccessioniPrimary (citable) accession number: B7ZC32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: February 22, 2012
Last modified: February 17, 2016
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence of the protein was deduced from the genomic sequence and ESTs by similarity to the mouse and rat sequence.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.