ID   B7ZBV9_MOUSE            Unreviewed;       870 AA.
AC   B7ZBV9;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   SubName: Full=Potassium voltage-gated channel, subfamily Q, member 2 {ECO:0000313|Ensembl:ENSMUSP00000122915.3};
GN   Name=Kcnq2 {ECO:0000313|Ensembl:ENSMUSP00000122915.3,
GN   ECO:0000313|MGI:MGI:1309503};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000122915.3, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0007829|PubMed:16452087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA   Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT   "Comprehensive identification of phosphorylation sites in postsynaptic
RT   density preparations.";
RL   Mol. Cell. Proteomics 5:914-922(2006).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000122915.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000122915.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000122915.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000122915.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   RefSeq; NP_034741.2; NM_010611.3.
DR   AlphaFoldDB; B7ZBV9; -.
DR   SMR; B7ZBV9; -.
DR   PeptideAtlas; B7ZBV9; -.
DR   ProteomicsDB; 337181; -.
DR   Antibodypedia; 15101; 328 antibodies from 31 providers.
DR   DNASU; 16536; -.
DR   Ensembl; ENSMUST00000149964.9; ENSMUSP00000122915.3; ENSMUSG00000016346.18.
DR   GeneID; 16536; -.
DR   UCSC; uc008okz.2; mouse.
DR   AGR; MGI:1309503; -.
DR   CTD; 3785; -.
DR   MGI; MGI:1309503; Kcnq2.
DR   VEuPathDB; HostDB:ENSMUSG00000016346; -.
DR   GeneTree; ENSGT00940000160093; -.
DR   OMA; TSWQPQG; -.
DR   OrthoDB; 2911641at2759; -.
DR   PhylomeDB; B7ZBV9; -.
DR   TreeFam; TF315186; -.
DR   BioGRID-ORCS; 16536; 1 hit in 78 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000016346; Expressed in CA1 field of hippocampus and 122 other cell types or tissues.
DR   ExpressionAtlas; B7ZBV9; baseline and differential.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR   GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 6.10.140.1910; -; 2.
DR   InterPro; IPR020969; Ankyrin-G_BS.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR003947; K_chnl_volt-dep_KCNQ2.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   PANTHER; PTHR47735:SF4; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2; 1.
DR   PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16642; KCNQ2_u3; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   Pfam; PF11956; KCNQC3-Ank-G_bd; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01461; KCNQ2CHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:B7ZBV9,
KW   ECO:0007829|MaxQB:B7ZBV9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   TRANSMEM        93..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        124..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        168..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        234..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        293..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          96..322
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          466..650
FT                   /note="Potassium channel voltage dependent KCNQ C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03520"
FT   REGION          447..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          597..620
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          712..737
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          836..870
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..487
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..612
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        714..729
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   870 AA;  95742 MW;  9C6106C27CE70C5F CRC64;
     MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR GSVLSKPRTG
     GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF LLVFSCLVLS VFSTIKEYEK
     SSEGALYILE IVTIVVFGVE YFVRIWAAGC CCRYRGWRGR LKFARKPFCV IDIMVLIASI
     AVLAAGSQGN VFATSALRSL RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF
     LCLILASFLV YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI
     GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN LSRTDLHSTW
     QYYERTVTVP MYSSQTQTYG ASRLIPPLNQ LELLRNLKSK SGLTFRKEPQ PEPSPSKGRP
     CRGCLCGCCP GHSSQKVSLK DRVFSSPRGM AAKGKGSPQA QTVRRSPSAD QSLDDSPSKV
     PKSWSFGDRS RTRQAFRIKG AASRQNSEEA SLPGEDIVED NKSCNCEFVT EDLTPGLKVS
     IRAVCVMRFL VSKRKFKESL RPYDVMDVIE QYSAGHLDML SRIKSLQSRV DQIVGRGPTI
     TDKDRTKGPA ETELPEDPSM MGRLGKVEKQ VLSMEKKLDF LVSIYTQRMG IPPAETEAYF
     GAKEPEPAPP YHSPEDSRDH ADKHGCIIKI VRSTSSTGQR NYAAPPAIPP AQCPPSTSWQ
     QSHQRHGTSP VGDHGSLVRI PPPPAHERSL SAYGGGNRAS TEFLRLEGTP ACRPSEAALR
     DSDTSISIPS VDHEELERSF SGFSISQSKE NLDALGSCYA AVAPCAKVRP YIAEGESDTD
     SDLCTPCGPP PRSATGEGPF GDVAWAGPRK
//