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Protein
Submitted name:

Potassium voltage-gated channel subfamily KQT member 2

Gene

Kcnq2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel subfamily KQT member 2Imported
Submitted name:
Potassium voltage-gated channel, subfamily Q, member 2, isoform CRA_hImported
Gene namesi
Name:Kcnq2Imported
ORF Names:mCG_23080Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1309503 Kcnq2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Transmembranei124 – 147HelicalSequence analysisAdd BLAST24
Transmembranei168 – 187HelicalSequence analysisAdd BLAST20
Transmembranei234 – 252HelicalSequence analysisAdd BLAST19
Transmembranei293 – 318HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000016346

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122915

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 318Ion_transInterPro annotationAdd BLAST223
Domaini466 – 651KCNQ_channelInterPro annotationAdd BLAST186

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1419 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00550000074513
HOGENOMiHOG000220839
HOVERGENiHBG059014
OMAiVTVPMYS
OrthoDBiEOG091G02ZT
TreeFamiTF315186

Family and domain databases

InterProiView protein in InterPro
IPR020969 Ankyrin-G_BS
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR003947 K_chnl_volt-dep_KCNQ2
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF6 PTHR11537:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 1 hit
PF11956 KCNQC3-Ank-G_bd, 1 hit
PRINTSiPR00169 KCHANNEL
PR01461 KCNQ2CHANNEL
PR01459 KCNQCHANNEL

Sequencei

Sequence statusi: Complete.

B7ZBV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR
60 70 80 90 100
GSVLSKPRTG GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF
110 120 130 140 150
LLVFSCLVLS VFSTIKEYEK SSEGALYILE IVTIVVFGVE YFVRIWAAGC
160 170 180 190 200
CCRYRGWRGR LKFARKPFCV IDIMVLIASI AVLAAGSQGN VFATSALRSL
210 220 230 240 250
RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF LCLILASFLV
260 270 280 290 300
YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI
310 320 330 340 350
GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN
360 370 380 390 400
LSRTDLHSTW QYYERTVTVP MYSSQTQTYG ASRLIPPLNQ LELLRNLKSK
410 420 430 440 450
SGLTFRKEPQ PEPSPSKGRP CRGCLCGCCP GHSSQKVSLK DRVFSSPRGM
460 470 480 490 500
AAKGKGSPQA QTVRRSPSAD QSLDDSPSKV PKSWSFGDRS RTRQAFRIKG
510 520 530 540 550
AASRQNSEEA SLPGEDIVED NKSCNCEFVT EDLTPGLKVS IRAVCVMRFL
560 570 580 590 600
VSKRKFKESL RPYDVMDVIE QYSAGHLDML SRIKSLQSRV DQIVGRGPTI
610 620 630 640 650
TDKDRTKGPA ETELPEDPSM MGRLGKVEKQ VLSMEKKLDF LVSIYTQRMG
660 670 680 690 700
IPPAETEAYF GAKEPEPAPP YHSPEDSRDH ADKHGCIIKI VRSTSSTGQR
710 720 730 740 750
NYAAPPAIPP AQCPPSTSWQ QSHQRHGTSP VGDHGSLVRI PPPPAHERSL
760 770 780 790 800
SAYGGGNRAS TEFLRLEGTP ACRPSEAALR DSDTSISIPS VDHEELERSF
810 820 830 840 850
SGFSISQSKE NLDALGSCYA AVAPCAKVRP YIAEGESDTD SDLCTPCGPP
860 870
PRSATGEGPF GDVAWAGPRK
Length:870
Mass (Da):95,742
Last modified:March 3, 2009 - v1
Checksum:i9C6106C27CE70C5F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei870Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450341 Genomic DNA No translation available.
CH466626 Genomic DNA Translation: EDL07381.1
RefSeqiNP_034741.2, NM_010611.3
UniGeneiMm.40615
Mm.440175

Genome annotation databases

EnsembliENSMUST00000149964; ENSMUSP00000122915; ENSMUSG00000016346
GeneIDi16536
UCSCiuc008okz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiB7ZBV9_MOUSE
AccessioniPrimary (citable) accession number: B7ZBV9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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