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B7ZBV9

- B7ZBV9_MOUSE

UniProt

B7ZBV9 - B7ZBV9_MOUSE

Protein
Submitted name:

Potassium voltage-gated channel subfamily KQT member 2

Gene

Kcnq2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. transmission of nerve impulse Source: MGI

    Keywords - Molecular functioni

    Ion channel, Potassium channelSAAS annotation

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Potassium voltage-gated channel subfamily KQT member 2Imported
    Submitted name:
    Potassium voltage-gated channel, subfamily Q, member 2, isoform CRA_hImported
    Gene namesi
    Name:Kcnq2Imported
    ORF Names:mCG_23080Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1309503. Kcnq2.

    Subcellular locationi

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00550000074513.
    HOGENOMiHOG000220839.
    HOVERGENiHBG059014.
    KOiK04927.
    OMAiSSMGQKN.
    OrthoDBiEOG73804Z.
    TreeFamiTF315186.

    Family and domain databases

    InterProiIPR020969. Ankyrin-G_BS.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003937. K_chnl_volt-dep_KCNQ.
    IPR003947. K_chnl_volt-dep_KCNQ2.
    IPR013821. K_chnl_volt-dep_KCNQ_C.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF00520. Ion_trans. 1 hit.
    PF03520. KCNQ_channel. 1 hit.
    PF11956. KCNQC3-Ank-G_bd. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01461. KCNQ2CHANNEL.
    PR01459. KCNQCHANNEL.

    Sequencei

    Sequence statusi: Complete.

    B7ZBV9-1 [UniParc]FASTAAdd to Basket

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    MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR    50
    GSVLSKPRTG GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF 100
    LLVFSCLVLS VFSTIKEYEK SSEGALYILE IVTIVVFGVE YFVRIWAAGC 150
    CCRYRGWRGR LKFARKPFCV IDIMVLIASI AVLAAGSQGN VFATSALRSL 200
    RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF LCLILASFLV 250
    YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI 300
    GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN 350
    LSRTDLHSTW QYYERTVTVP MYSSQTQTYG ASRLIPPLNQ LELLRNLKSK 400
    SGLTFRKEPQ PEPSPSKGRP CRGCLCGCCP GHSSQKVSLK DRVFSSPRGM 450
    AAKGKGSPQA QTVRRSPSAD QSLDDSPSKV PKSWSFGDRS RTRQAFRIKG 500
    AASRQNSEEA SLPGEDIVED NKSCNCEFVT EDLTPGLKVS IRAVCVMRFL 550
    VSKRKFKESL RPYDVMDVIE QYSAGHLDML SRIKSLQSRV DQIVGRGPTI 600
    TDKDRTKGPA ETELPEDPSM MGRLGKVEKQ VLSMEKKLDF LVSIYTQRMG 650
    IPPAETEAYF GAKEPEPAPP YHSPEDSRDH ADKHGCIIKI VRSTSSTGQR 700
    NYAAPPAIPP AQCPPSTSWQ QSHQRHGTSP VGDHGSLVRI PPPPAHERSL 750
    SAYGGGNRAS TEFLRLEGTP ACRPSEAALR DSDTSISIPS VDHEELERSF 800
    SGFSISQSKE NLDALGSCYA AVAPCAKVRP YIAEGESDTD SDLCTPCGPP 850
    PRSATGEGPF GDVAWAGPRK 870
    Length:870
    Mass (Da):95,742
    Last modified:March 3, 2009 - v1
    Checksum:i9C6106C27CE70C5F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei870 – 8701Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL450341 Genomic DNA. No translation available.
    CH466626 Genomic DNA. Translation: EDL07381.1.
    RefSeqiNP_034741.2. NM_010611.2.
    UniGeneiMm.40615.
    Mm.440175.

    Genome annotation databases

    EnsembliENSMUST00000149964; ENSMUSP00000122915; ENSMUSG00000016346.
    GeneIDi16536.
    KEGGimmu:16536.
    UCSCiuc008okz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL450341 Genomic DNA. No translation available.
    CH466626 Genomic DNA. Translation: EDL07381.1 .
    RefSeqi NP_034741.2. NM_010611.2.
    UniGenei Mm.40615.
    Mm.440175.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 16536.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000149964 ; ENSMUSP00000122915 ; ENSMUSG00000016346 .
    GeneIDi 16536.
    KEGGi mmu:16536.
    UCSCi uc008okz.1. mouse.

    Organism-specific databases

    CTDi 3785.
    MGIi MGI:1309503. Kcnq2.

    Phylogenomic databases

    GeneTreei ENSGT00550000074513.
    HOGENOMi HOG000220839.
    HOVERGENi HBG059014.
    KOi K04927.
    OMAi SSMGQKN.
    OrthoDBi EOG73804Z.
    TreeFami TF315186.

    Miscellaneous databases

    NextBioi 289965.
    SOURCEi Search...

    Family and domain databases

    InterProi IPR020969. Ankyrin-G_BS.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003937. K_chnl_volt-dep_KCNQ.
    IPR003947. K_chnl_volt-dep_KCNQ2.
    IPR013821. K_chnl_volt-dep_KCNQ_C.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF00520. Ion_trans. 1 hit.
    PF03520. KCNQ_channel. 1 hit.
    PF11956. KCNQC3-Ank-G_bd. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01461. KCNQ2CHANNEL.
    PR01459. KCNQCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiB7ZBV9_MOUSE
    AccessioniPrimary (citable) accession number: B7ZBV9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3