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Protein
Submitted name:

Potassium voltage-gated channel subfamily KQT member 2

Gene

Kcnq2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel subfamily KQT member 2Imported
Gene namesi
Name:Kcnq2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1309503 Kcnq2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 112HelicalSequence analysisAdd BLAST20
Transmembranei124 – 147HelicalSequence analysisAdd BLAST24
Transmembranei168 – 187HelicalSequence analysisAdd BLAST20
Transmembranei234 – 252HelicalSequence analysisAdd BLAST19
Transmembranei264 – 281HelicalSequence analysisAdd BLAST18
Transmembranei293 – 318HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiB7ZBV6

Expressioni

Gene expression databases

BgeeiENSMUSG00000016346
ExpressionAtlasiB7ZBV6 baseline and differential
GenevisibleiB7ZBV6 MM

Structurei

3D structure databases

ProteinModelPortaliB7ZBV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 318Ion_transInterPro annotationAdd BLAST223
Domaini438 – 565KCNQ_channelInterPro annotationAdd BLAST128
Domaini589 – 654KCNQ_channelInterPro annotationAdd BLAST66

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00550000074513
HOVERGENiHBG059014

Family and domain databases

InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR003937 K_chnl_volt-dep_KCNQ
IPR003947 K_chnl_volt-dep_KCNQ2
IPR013821 K_chnl_volt-dep_KCNQ_C
IPR028325 VG_K_chnl
PANTHERiPTHR11537 PTHR11537, 1 hit
PTHR11537:SF6 PTHR11537:SF6, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF03520 KCNQ_channel, 2 hits
PRINTSiPR00169 KCHANNEL
PR01461 KCNQ2CHANNEL
PR01459 KCNQCHANNEL

Sequencei

Sequence statusi: Complete.

B7ZBV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQKSRNGGV YPGTSGEKKL KVGFVGLDPG APDSTRDGAL LIAGSEAPKR
60 70 80 90 100
GSVLSKPRTG GAGAGKPPKR NAFYRKLQNF LYNVLERPRG WAFIYHAYVF
110 120 130 140 150
LLVFSCLVLS VFSTIKEYEK SSEGALYILE IVTIVVFGVE YFVRIWAAGC
160 170 180 190 200
CCRYRGWRGR LKFARKPFCV IDIMVLIASI AVLAAGSQGN VFATSALRSL
210 220 230 240 250
RFLQILRMIR MDRRGGTWKL LGSVVYAHSK ELVTAWYIGF LCLILASFLV
260 270 280 290 300
YLAEKGENDH FDTYADALWW GLITLTTIGY GDKYPQTWNG RLLAATFTLI
310 320 330 340 350
GVSFFALPAG ILGSGFALKV QEQHRQKHFE KRRNPAAGLI QSAWRFYATN
360 370 380 390 400
LSRTDLHSTW QYYERTVTVP MYRLIPPLNQ LELLRNLKSK SGLTFRKEPQ
410 420 430 440 450
PEPSPSQKVS LKDRVFSSPR GMAAKGKGSP QAQTVRRSPS ADQSLDDSPS
460 470 480 490 500
KVPKSWSFGD RSRTRQAFRI KGAASRQNSE EASLPGEDIV EDNKSCNCEF
510 520 530 540 550
VTEDLTPGLK VSIRAVCVMR FLVSKRKFKE SLRPYDVMDV IEQYSAGHLD
560 570 580 590 600
MLSRIKSLQS RQEPLPVQSG HEQGPPGQNQ AWHKGHQGLG DRVDQIVGRG
610 620 630 640 650
PTITDKDRTK GPAETELPED PSMMGRLGKV EKQVLSMEKK LDFLVSIYTQ
660 670 680 690 700
RMGIPPAETE AYFGAKEPEP APPYHSPEDS RDHADKHGCI IKIVRSTSST
710 720 730 740 750
GQRNYAAPPA IPPAQCPPST SWQQSHQRHG TSPVGDHGSL VLRLERSAGM

MSCH
Length:754
Mass (Da):83,893
Last modified:March 3, 2009 - v1
Checksum:i1A1864896B50660E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL450341 Genomic DNA No translation available.
RefSeqiNP_001003825.1, NM_001003825.3
UniGeneiMm.40615
Mm.440175

Genome annotation databases

EnsembliENSMUST00000049792; ENSMUSP00000052453; ENSMUSG00000016346
GeneIDi16536
UCSCiuc008oku.2 mouse

Similar proteinsi

Entry informationi

Entry nameiB7ZBV6_MOUSE
AccessioniPrimary (citable) accession number: B7ZBV6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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