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Protein

Protein phosphatase 1 regulatory subunit 3G

Gene

PPP1R3G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32825-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3G
Gene namesi
Name:PPP1R3G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14945. PPP1R3G.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000219607.
PharmGKBiPA33657.

Polymorphism and mutation databases

BioMutaiPPP1R3G.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003949651 – 358Protein phosphatase 1 regulatory subunit 3GAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB7ZBB8.
PRIDEiB7ZBB8.

PTM databases

iPTMnetiB7ZBB8.
PhosphoSitePlusiB7ZBB8.

Expressioni

Gene expression databases

BgeeiENSG00000219607.

Organism-specific databases

HPAiHPA056393.

Interactioni

Protein-protein interaction databases

BioGridi572922. 1 interactor.
IntActiB7ZBB8. 1 interactor.
STRINGi9606.ENSP00000393832.

Structurei

3D structure databases

ProteinModelPortaliB7ZBB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini210 – 350CBM21PROSITE-ProRule annotationAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 105Poly-Gln6
Compositional biasi182 – 188Poly-Ala7

Sequence similaritiesi

Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
GeneTreeiENSGT00530000062978.
HOGENOMiHOG000082433.
HOVERGENiHBG106533.
InParanoidiB7ZBB8.
OMAiFAVCYRC.
OrthoDBiEOG091G0FLS.
PhylomeDBiB7ZBB8.
TreeFamiTF105537.

Family and domain databases

InterProiIPR005036. CBM21_dom.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZBB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPIGARLSL EAPGPAPFRE APPAEELPAP VVPCVQGGGD GGGASETPSP
60 70 80 90 100
DAQLGDRPLS PKEEAAPQEQ EELLECRRRC RARSFSLPAD PILQAAKFLQ
110 120 130 140 150
QQQQQAVALG GEGAEDAQLG PGGCCAKCKK RVQFADTLGL SLASVKHFSE
160 170 180 190 200
AEEPQVPPAV LSRLRSFPMR AEDLEQLGGL LAAAAVAAPL SAPPSRLRPL
210 220 230 240 250
FQLPGPSAAA ERLQRQRVCL ERVQCSTASG AEVKGSGRVL SCPGPRAVTV
260 270 280 290 300
RYTFTEWRSF LDVPAELQPE PLEPQQPEAP SGASEPGSGD AKKEPGAECF
310 320 330 340 350
HFSLCLPPGL QPEDEEDADE RGVAVHFAVC YRCAQGEYWD NNAGANYTLR

YARPADAL
Length:358
Mass (Da):38,019
Last modified:March 3, 2009 - v1
Checksum:i8976D05A4FA43F1F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063262280P → Q.Corresponds to variant rs436556dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035653 Genomic DNA. Translation: CAI22358.2.
CCDSiCCDS47366.1.
RefSeqiNP_001138587.1. NM_001145115.2.
UniGeneiHs.653089.

Genome annotation databases

EnsembliENST00000405617; ENSP00000393832; ENSG00000219607.
GeneIDi648791.
KEGGihsa:648791.
UCSCiuc011dia.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035653 Genomic DNA. Translation: CAI22358.2.
CCDSiCCDS47366.1.
RefSeqiNP_001138587.1. NM_001145115.2.
UniGeneiHs.653089.

3D structure databases

ProteinModelPortaliB7ZBB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi572922. 1 interactor.
IntActiB7ZBB8. 1 interactor.
STRINGi9606.ENSP00000393832.

PTM databases

iPTMnetiB7ZBB8.
PhosphoSitePlusiB7ZBB8.

Polymorphism and mutation databases

BioMutaiPPP1R3G.

Proteomic databases

PaxDbiB7ZBB8.
PRIDEiB7ZBB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000405617; ENSP00000393832; ENSG00000219607.
GeneIDi648791.
KEGGihsa:648791.
UCSCiuc011dia.2. human.

Organism-specific databases

CTDi648791.
GeneCardsiPPP1R3G.
HGNCiHGNC:14945. PPP1R3G.
HPAiHPA056393.
neXtProtiNX_B7ZBB8.
OpenTargetsiENSG00000219607.
PharmGKBiPA33657.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
GeneTreeiENSGT00530000062978.
HOGENOMiHOG000082433.
HOVERGENiHBG106533.
InParanoidiB7ZBB8.
OMAiFAVCYRC.
OrthoDBiEOG091G0FLS.
PhylomeDBiB7ZBB8.
TreeFamiTF105537.

Enzyme and pathway databases

BioCyciZFISH:G66-32825-MONOMER.

Miscellaneous databases

GenomeRNAii648791.
PROiB7ZBB8.

Gene expression databases

BgeeiENSG00000219607.

Family and domain databases

InterProiIPR005036. CBM21_dom.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP13G_HUMAN
AccessioniPrimary (citable) accession number: B7ZBB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.