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B7ZBB8

- PP13G_HUMAN

UniProt

B7ZBB8 - PP13G_HUMAN

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Protein

Protein phosphatase 1 regulatory subunit 3G

Gene

PPP1R3G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity).By similarity

GO - Molecular functioni

  1. glycogen binding Source: Ensembl

GO - Biological processi

  1. glucose homeostasis Source: Ensembl
  2. positive regulation of glycogen (starch) synthase activity Source: Ensembl
  3. positive regulation of glycogen biosynthetic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3G
Gene namesi
Name:PPP1R3G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:14945. PPP1R3G.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33657.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Protein phosphatase 1 regulatory subunit 3GPRO_0000394965Add
BLAST

Proteomic databases

PaxDbiB7ZBB8.
PRIDEiB7ZBB8.

PTM databases

PhosphoSiteiB7ZBB8.

Expressioni

Gene expression databases

BgeeiB7ZBB8.

Organism-specific databases

HPAiHPA056393.

Interactioni

Protein-protein interaction databases

BioGridi572922. 1 interaction.
IntActiB7ZBB8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliB7ZBB8.
SMRiB7ZBB8. Positions 197-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini210 – 350141CBM21PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi100 – 1056Poly-Gln
Compositional biasi182 – 1887Poly-Ala

Sequence similaritiesi

Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG303539.
GeneTreeiENSGT00530000062978.
HOGENOMiHOG000082433.
HOVERGENiHBG106533.
InParanoidiB7ZBB8.
OMAiFAVCYRC.
OrthoDBiEOG7CK37Q.
PhylomeDBiB7ZBB8.
TreeFamiTF105537.

Family and domain databases

InterProiIPR005036. CBM_21.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZBB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPIGARLSL EAPGPAPFRE APPAEELPAP VVPCVQGGGD GGGASETPSP
60 70 80 90 100
DAQLGDRPLS PKEEAAPQEQ EELLECRRRC RARSFSLPAD PILQAAKFLQ
110 120 130 140 150
QQQQQAVALG GEGAEDAQLG PGGCCAKCKK RVQFADTLGL SLASVKHFSE
160 170 180 190 200
AEEPQVPPAV LSRLRSFPMR AEDLEQLGGL LAAAAVAAPL SAPPSRLRPL
210 220 230 240 250
FQLPGPSAAA ERLQRQRVCL ERVQCSTASG AEVKGSGRVL SCPGPRAVTV
260 270 280 290 300
RYTFTEWRSF LDVPAELQPE PLEPQQPEAP SGASEPGSGD AKKEPGAECF
310 320 330 340 350
HFSLCLPPGL QPEDEEDADE RGVAVHFAVC YRCAQGEYWD NNAGANYTLR

YARPADAL
Length:358
Mass (Da):38,019
Last modified:March 3, 2009 - v1
Checksum:i8976D05A4FA43F1F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti280 – 2801P → Q.
Corresponds to variant rs436556 [ dbSNP | Ensembl ].
VAR_063262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035653 Genomic DNA. Translation: CAI22358.2.
CCDSiCCDS47366.1.
RefSeqiNP_001138587.1. NM_001145115.2.
UniGeneiHs.653089.

Genome annotation databases

EnsembliENST00000405617; ENSP00000393832; ENSG00000219607.
GeneIDi648791.
KEGGihsa:648791.
UCSCiuc011dia.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035653 Genomic DNA. Translation: CAI22358.2 .
CCDSi CCDS47366.1.
RefSeqi NP_001138587.1. NM_001145115.2.
UniGenei Hs.653089.

3D structure databases

ProteinModelPortali B7ZBB8.
SMRi B7ZBB8. Positions 197-349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 572922. 1 interaction.
IntActi B7ZBB8. 1 interaction.

PTM databases

PhosphoSitei B7ZBB8.

Proteomic databases

PaxDbi B7ZBB8.
PRIDEi B7ZBB8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000405617 ; ENSP00000393832 ; ENSG00000219607 .
GeneIDi 648791.
KEGGi hsa:648791.
UCSCi uc011dia.1. human.

Organism-specific databases

CTDi 648791.
GeneCardsi GC06P005085.
HGNCi HGNC:14945. PPP1R3G.
HPAi HPA056393.
neXtProti NX_B7ZBB8.
PharmGKBi PA33657.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG303539.
GeneTreei ENSGT00530000062978.
HOGENOMi HOG000082433.
HOVERGENi HBG106533.
InParanoidi B7ZBB8.
OMAi FAVCYRC.
OrthoDBi EOG7CK37Q.
PhylomeDBi B7ZBB8.
TreeFami TF105537.

Miscellaneous databases

GenomeRNAii 648791.
NextBioi 120600.
PROi B7ZBB8.

Gene expression databases

Bgeei B7ZBB8.

Family and domain databases

InterProi IPR005036. CBM_21.
[Graphical view ]
Pfami PF03370. CBM_21. 1 hit.
[Graphical view ]
PROSITEi PS51159. CBM21. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution."
    Ceulemans H., Stalmans W., Bollen M.
    Bioessays 24:371-381(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiPP13G_HUMAN
AccessioniPrimary (citable) accession number: B7ZBB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3