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B7ZBB8

- PP13G_HUMAN

UniProt

B7ZBB8 - PP13G_HUMAN

Protein

Protein phosphatase 1 regulatory subunit 3G

Gene

PPP1R3G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits By similarity.By similarity

    GO - Molecular functioni

    1. glycogen binding Source: Ensembl

    GO - Biological processi

    1. glucose homeostasis Source: Ensembl
    2. positive regulation of glycogen (starch) synthase activity Source: Ensembl
    3. positive regulation of glycogen biosynthetic process Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1 regulatory subunit 3G
    Gene namesi
    Name:PPP1R3G
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:14945. PPP1R3G.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33657.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Protein phosphatase 1 regulatory subunit 3GPRO_0000394965Add
    BLAST

    Proteomic databases

    PaxDbiB7ZBB8.
    PRIDEiB7ZBB8.

    PTM databases

    PhosphoSiteiB7ZBB8.

    Expressioni

    Gene expression databases

    BgeeiB7ZBB8.

    Organism-specific databases

    HPAiHPA056393.

    Interactioni

    Protein-protein interaction databases

    BioGridi572922. 1 interaction.
    IntActiB7ZBB8. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliB7ZBB8.
    SMRiB7ZBB8. Positions 212-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini210 – 350141CBM21PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi100 – 1056Poly-Gln
    Compositional biasi182 – 1887Poly-Ala

    Sequence similaritiesi

    Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG303539.
    HOGENOMiHOG000082433.
    HOVERGENiHBG106533.
    OMAiFAVCYRC.
    OrthoDBiEOG7CK37Q.
    PhylomeDBiB7ZBB8.
    TreeFamiTF105537.

    Family and domain databases

    InterProiIPR005036. CBM_21.
    [Graphical view]
    PfamiPF03370. CBM_21. 1 hit.
    [Graphical view]
    PROSITEiPS51159. CBM21. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7ZBB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPIGARLSL EAPGPAPFRE APPAEELPAP VVPCVQGGGD GGGASETPSP    50
    DAQLGDRPLS PKEEAAPQEQ EELLECRRRC RARSFSLPAD PILQAAKFLQ 100
    QQQQQAVALG GEGAEDAQLG PGGCCAKCKK RVQFADTLGL SLASVKHFSE 150
    AEEPQVPPAV LSRLRSFPMR AEDLEQLGGL LAAAAVAAPL SAPPSRLRPL 200
    FQLPGPSAAA ERLQRQRVCL ERVQCSTASG AEVKGSGRVL SCPGPRAVTV 250
    RYTFTEWRSF LDVPAELQPE PLEPQQPEAP SGASEPGSGD AKKEPGAECF 300
    HFSLCLPPGL QPEDEEDADE RGVAVHFAVC YRCAQGEYWD NNAGANYTLR 350
    YARPADAL 358
    Length:358
    Mass (Da):38,019
    Last modified:March 3, 2009 - v1
    Checksum:i8976D05A4FA43F1F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti280 – 2801P → Q.
    Corresponds to variant rs436556 [ dbSNP | Ensembl ].
    VAR_063262

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035653 Genomic DNA. Translation: CAI22358.2.
    CCDSiCCDS47366.1.
    RefSeqiNP_001138587.1. NM_001145115.2.
    UniGeneiHs.653089.

    Genome annotation databases

    EnsembliENST00000405617; ENSP00000393832; ENSG00000219607.
    GeneIDi648791.
    KEGGihsa:648791.
    UCSCiuc011dia.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL035653 Genomic DNA. Translation: CAI22358.2 .
    CCDSi CCDS47366.1.
    RefSeqi NP_001138587.1. NM_001145115.2.
    UniGenei Hs.653089.

    3D structure databases

    ProteinModelPortali B7ZBB8.
    SMRi B7ZBB8. Positions 212-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 572922. 1 interaction.
    IntActi B7ZBB8. 1 interaction.

    PTM databases

    PhosphoSitei B7ZBB8.

    Proteomic databases

    PaxDbi B7ZBB8.
    PRIDEi B7ZBB8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000405617 ; ENSP00000393832 ; ENSG00000219607 .
    GeneIDi 648791.
    KEGGi hsa:648791.
    UCSCi uc011dia.1. human.

    Organism-specific databases

    CTDi 648791.
    GeneCardsi GC06P005085.
    HGNCi HGNC:14945. PPP1R3G.
    HPAi HPA056393.
    neXtProti NX_B7ZBB8.
    PharmGKBi PA33657.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG303539.
    HOGENOMi HOG000082433.
    HOVERGENi HBG106533.
    OMAi FAVCYRC.
    OrthoDBi EOG7CK37Q.
    PhylomeDBi B7ZBB8.
    TreeFami TF105537.

    Miscellaneous databases

    GenomeRNAii 648791.
    NextBioi 120600.
    PROi B7ZBB8.

    Gene expression databases

    Bgeei B7ZBB8.

    Family and domain databases

    InterProi IPR005036. CBM_21.
    [Graphical view ]
    Pfami PF03370. CBM_21. 1 hit.
    [Graphical view ]
    PROSITEi PS51159. CBM21. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution."
      Ceulemans H., Stalmans W., Bollen M.
      Bioessays 24:371-381(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiPP13G_HUMAN
    AccessioniPrimary (citable) accession number: B7ZBB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3