B7ZB79 (B7ZB79_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA, FLJ79443, highly similar to Frizzled-6 EMBL BAH14915.1
Organism	Homo sapiens (Human) EMBL BAH14915.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	672 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 FZ (frizzled) domain. SAAS SAAS015526

Ontologies

Keywords
Biological process	Wnt signaling pathway SAAS SAAS015526
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS015526
Molecular function	Developmental protein SAAS SAAS015526 G-protein coupled receptor SAAS SAAS015526 Receptor Transducer
PTM	Disulfide bond SAAS SAAS015526
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway, planar cell polarity pathway Inferred from electronic annotation. Source: Compara cell proliferation in midbrain Inferred from electronic annotation. Source: Compara establishment of planar polarity Inferred from electronic annotation. Source: Compara hair follicle development Inferred from electronic annotation. Source: Compara inner ear morphogenesis Inferred from electronic annotation. Source: Compara neural tube closure Inferred from electronic annotation. Source: Compara platelet activation Inferred from electronic annotation. Source: Compara
Cellular_component	apical part of cell Inferred from electronic annotation. Source: Compara apicolateral plasma membrane Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW Wnt-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7ZB79 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: EBF580CD955A9864	FASTA	672	75,320
	10 20 30 40 50 60 MAYNMTFFPN LMGHYDQSIA AVEMEHFLPL ANLECSPNIE TFLCKAFVPT CIEQIHVVPP 70 80 90 100 110 120 CRKLCEKVYS DCKKLIDTFG IRWPEELECD RLQYCDETVP VTFDPHTEFL GPQKKTEQVQ 130 140 150 160 170 180 RDIGFWCPRH LKTSGGQGYK FLGIDQCAPP CPNMYFKSDE LEFAKSFIGT VSIFCLCATL 190 200 210 220 230 240 FTFLTFLIDV RRFRYPERPI IYYSVCYSIV SLMYFIGFLL GDSTACNKAD EKLELGDTVV 250 260 270 280 290 300 LGSQNKACTV LFMLLYFFTM AGTVWWVILT ITWFLAAGRK WSCEAIEQKA VWFHAVAWGT 310 320 330 340 350 360 PGFLTVMLLA MNKVEGDNIS GVCFVGLYDL DASRYFVLLP LCLCVFVGLS LLLAGIISLN 370 380 390 400 410 420 HVRQVIQHDG RNQEKLKKFM IRIGVFSGLY LVPLVTLLGC YVYEQVNRIT WEITWVSDHC 430 440 450 460 470 480 RQYHIPCPYQ AKAKARPELA LFMIKYLMTL IVGISAVFWV GSKKTCTEWA GFFKRNRKRD 490 500 510 520 530 540 PISESRRVLQ ESCEFFLKHN SKVKHKKKHY KPSSHKLKVI SKSMGTSTGA TANHGTSAVA 550 560 570 580 590 600 ITSHDYLGQE TLTEIQTSPE TSMREVKADG ASTPRLREQD CGEPASPAAS ISRLSGEQVD 610 620 630 640 650 660 GKGQAGSVSE SARSEGRISP KSDITDTGLA QSNNLQVPSS SEPSSLKGST SLLVHPVSGV 670 RKEQGGGCHS DT

References

[1]

"NEDO human cDNA sequencing project." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Uterus EMBL BAH14915.1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK316544 mRNA. Translation: BAH14915.1.
IPI	IPI01012835.
UniGene	Hs.591863.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B7ZB79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006977.
Gene expression databases
ArrayExpress	B7ZB79.
Bgee	B7ZB79.
Family and domain databases
Gene3D	1.10.2000.10. 1 hit.
InterPro	IPR000539. Frizzled. IPR015526. Frizzled/SFRP. IPR020067. Frizzled_dom. IPR026543. FZD6. IPR017981. GPCR_2-like. [Graphical view]
PANTHER	PTHR11309. PTHR11309. 1 hit. PTHR11309:SF21. PTHR11309:SF21. 1 hit.
Pfam	PF01534. Frizzled. 1 hit. PF01392. Fz. 1 hit. [Graphical view]
PRINTS	PR00489. FRIZZLED.
SMART	SM00063. FRI. 1 hit. [Graphical view]
SUPFAM	SSF63501. Frizzled_Cys-rich. 1 hit.
PROSITE	PS50038. FZ. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35481005.

Entry information

Entry name

B7ZB79_HUMAN

Accession

Primary (citable) accession number: B7ZB79

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	April 3, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.