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Protein
Submitted name:

cDNA, FLJ79443, highly similar to Frizzled-6

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. Wnt-activated receptor activity Source: InterPro

GO - Biological processi

  1. cell proliferation in midbrain Source: Ensembl
  2. embryonic nail plate morphogenesis Source: Ensembl
  3. establishment of planar polarity Source: Ensembl
  4. hair follicle development Source: Ensembl
  5. inner ear morphogenesis Source: Ensembl
  6. neural tube closure Source: Ensembl
  7. platelet activation Source: Ensembl
  8. Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinSAAS annotation, ReceptorSAAS annotation

Keywords - Biological processi

Wnt signaling pathwaySAAS annotation

Protein family/group databases

MEROPSiI93.001.

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA, FLJ79443, highly similar to Frizzled-6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. apicolateral plasma membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiB7ZB79.
ExpressionAtlasiB7ZB79. baseline and differential.

Family & Domainsi

Sequence similaritiesi

Contains FZ (frizzled) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG006977.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF75. PTHR11309:SF75. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZB79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYNMTFFPN LMGHYDQSIA AVEMEHFLPL ANLECSPNIE TFLCKAFVPT
60 70 80 90 100
CIEQIHVVPP CRKLCEKVYS DCKKLIDTFG IRWPEELECD RLQYCDETVP
110 120 130 140 150
VTFDPHTEFL GPQKKTEQVQ RDIGFWCPRH LKTSGGQGYK FLGIDQCAPP
160 170 180 190 200
CPNMYFKSDE LEFAKSFIGT VSIFCLCATL FTFLTFLIDV RRFRYPERPI
210 220 230 240 250
IYYSVCYSIV SLMYFIGFLL GDSTACNKAD EKLELGDTVV LGSQNKACTV
260 270 280 290 300
LFMLLYFFTM AGTVWWVILT ITWFLAAGRK WSCEAIEQKA VWFHAVAWGT
310 320 330 340 350
PGFLTVMLLA MNKVEGDNIS GVCFVGLYDL DASRYFVLLP LCLCVFVGLS
360 370 380 390 400
LLLAGIISLN HVRQVIQHDG RNQEKLKKFM IRIGVFSGLY LVPLVTLLGC
410 420 430 440 450
YVYEQVNRIT WEITWVSDHC RQYHIPCPYQ AKAKARPELA LFMIKYLMTL
460 470 480 490 500
IVGISAVFWV GSKKTCTEWA GFFKRNRKRD PISESRRVLQ ESCEFFLKHN
510 520 530 540 550
SKVKHKKKHY KPSSHKLKVI SKSMGTSTGA TANHGTSAVA ITSHDYLGQE
560 570 580 590 600
TLTEIQTSPE TSMREVKADG ASTPRLREQD CGEPASPAAS ISRLSGEQVD
610 620 630 640 650
GKGQAGSVSE SARSEGRISP KSDITDTGLA QSNNLQVPSS SEPSSLKGST
660 670
SLLVHPVSGV RKEQGGGCHS DT
Length:672
Mass (Da):75,320
Last modified:March 3, 2009 - v1
Checksum:iEBF580CD955A9864
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316544 mRNA. Translation: BAH14915.1.
UniGeneiHs.591863.
Hs.676099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316544 mRNA. Translation: BAH14915.1.
UniGeneiHs.591863.
Hs.676099.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI93.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006977.

Miscellaneous databases

NextBioi35481005.

Gene expression databases

BgeeiB7ZB79.
ExpressionAtlasiB7ZB79. baseline and differential.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026543. FZD6.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF75. PTHR11309:SF75. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: UterusImported.

Entry informationi

Entry nameiB7ZB79_HUMAN
AccessioniPrimary (citable) accession number: B7ZB79
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.