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Protein
Submitted name:

cDNA, FLJ79381, highly similar to Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ribonucleoprotein, Ribosomal proteinImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB7ZB17.

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA, FLJ79381, highly similar to Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiB7ZB17.
PaxDbiB7ZB17.

Expressioni

Gene expression databases

BgeeiB7ZB17.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368884.

Chemistry

BindingDBiB7ZB17.

Structurei

3D structure databases

ProteinModelPortaliB7ZB17.
SMRiB7ZB17. Positions 23-686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 299260Protein kinaseInterPro annotationAdd
BLAST
Domaini300 – 36970AGC-kinase C-terminalInterPro annotationAdd
BLAST
Domaini394 – 651258Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
HOVERGENiHBG108317.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZB17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEPMGEEEI NPQTEEVSIK EIAITHHVKE GHEKADPSQF ELLKVLGQGS
60 70 80 90 100
FGKVFLVKKI SGSDARQLYA MKVLKKATLK VRDRVRTKME RDILVEVNHP
110 120 130 140 150
FIVKLHYAFQ TEGKLYLILD FLRGGDLFTR LSKEVMFTEE DVKFYLAELA
160 170 180 190 200
LALDHLHSLG IIYRDLKPEN ILLDEEGHIK LTDFGLSKES IDHEKKAYSF
210 220 230 240 250
CGTVEYMAPE VVNRRGHTQS ADWWSFGVLM FEMLTGTLPF QGKDRKETMT
260 270 280 290 300
MILKAKLGMP QFLSPEAQSL LRMLFKRNPA NRLGAGPDGV EEIKRHSFFS
310 320 330 340 350
TIDWNKLYRR EIHPPFKPAT GRPEDTFYFD PEFTAKTPKD SPGIPPSANA
360 370 380 390 400
HQLFRGFSFV AITSDDESQA MQTVGVHSIV QQLHRNSIQF TDGYEVKEDI
410 420 430 440 450
GVGSYSVCKR CIHKATNMEF AVKIIDKSKR DPTEEIEILL RYGQHPNIIT
460 470 480 490 500
LKDVYDDGKY VYVVTELMKG GELLDKILRQ KFFSEREASA VLFTITKTVE
510 520 530 540 550
YLHAQGVVHR DLKPSNILYV DESGNPESIR ICDFGFAKQL RAENGLLMTP
560 570 580 590 600
CYTANFVAPE VLKRQGYDAA CDIWSLGVLL YTMLTGYTPF ANGPDDTPEE
610 620 630 640 650
ILARIGSGKF SLSGGYWNSV SDTAKDLVSK MLHVDPHQRL TAALVLRHPW
660 670 680 690 700
IVHWDQLPQY QLNRQDAPHL VKGAMAATYS ALNRNQSPVL EPVGRSTLAQ
710
RRGIKKITST AL
Length:712
Mass (Da):80,712
Last modified:March 3, 2009 - v1
Checksum:i35E91ECC97020DF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316482 mRNA. Translation: BAH14853.1.
RefSeqiXP_011543865.1. XM_011545563.1.
UniGeneiHs.445387.

Genome annotation databases

GeneIDi6197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316482 mRNA. Translation: BAH14853.1.
RefSeqiXP_011543865.1. XM_011545563.1.
UniGeneiHs.445387.

3D structure databases

ProteinModelPortaliB7ZB17.
SMRiB7ZB17. Positions 23-686.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368884.

Chemistry

BindingDBiB7ZB17.

Proteomic databases

EPDiB7ZB17.
PaxDbiB7ZB17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6197.

Organism-specific databases

CTDi6197.

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
HOVERGENiHBG108317.

Enzyme and pathway databases

SignaLinkiB7ZB17.

Miscellaneous databases

ChiTaRSiRPS6KA3. human.
GenomeRNAii6197.
NextBioi35480980.

Gene expression databases

BgeeiB7ZB17.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: ThymusImported.

Entry informationi

Entry nameiB7ZB17_HUMAN
AccessioniPrimary (citable) accession number: B7ZB17
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: May 11, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.