ID   B7ZB02_HUMAN            Unreviewed;       114 AA.
AC   B7ZB02;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=Ribose-phosphate pyrophosphokinase 1 {ECO:0000256|ARBA:ARBA00040334};
DE            EC=2.7.6.1 {ECO:0000256|ARBA:ARBA00013247};
DE   AltName: Full=Phosphoribosyl pyrophosphate synthase I {ECO:0000256|ARBA:ARBA00042458};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH14838.1};
RN   [1] {ECO:0000313|EMBL:BAH14838.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thymus {ECO:0000313|EMBL:BAH14838.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC       {ECO:0000256|ARBA:ARBA00006478}.
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DR   EMBL; AK316467; BAH14838.1; -; mRNA.
DR   RefSeq; NP_001191331.1; NM_001204402.1.
DR   AlphaFoldDB; B7ZB02; -.
DR   PeptideAtlas; B7ZB02; -.
DR   Antibodypedia; 29313; 196 antibodies from 29 providers.
DR   DNASU; 5631; -.
DR   GeneID; 5631; -.
DR   UCSC; uc011msj.2; human.
DR   CTD; 5631; -.
DR   VEuPathDB; HostDB:ENSG00000147224; -.
DR   HOGENOM; CLU_033546_9_2_1; -.
DR   OrthoDB; 276387at2759; -.
DR   BioGRID-ORCS; 5631; 20 hits in 779 CRISPR screens.
DR   ChiTaRS; PRPS1; human.
DR   GenomeRNAi; 5631; -.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:InterPro.
DR   GO; GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 2.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR005946; Rib-P_diPkinase.
DR   NCBIfam; TIGR01251; ribP_PPkin; 1.
DR   PANTHER; PTHR10210:SF32; RIBOSE-PHOSPHATE DIPHOSPHOKINASE; 1.
DR   PANTHER; PTHR10210; RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER; 1.
DR   Pfam; PF14572; Pribosyl_synth; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
PE   1: Evidence at protein level;
KW   Kinase {ECO:0000313|EMBL:BAH14838.1};
KW   Transferase {ECO:0000313|EMBL:BAH14838.1}.
SQ   SEQUENCE   114 AA;  12324 MW;  A2BA69EDAB8EF6B9 CRC64;
     MVLVGDVKDR VAILVDDMAD TCGTICHAAD KLLSAGATRV YAILTHGIFS GPAISRINNA
     CFEAVVVTNT IPQEDKMKHC SKIQVIDISM ILAEAIRRTH NGESVSYLFS HVPL
//