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Protein
Submitted name:

T-complex protein 1 subunit epsilon

Gene

CCT5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
T-complex protein 1 subunit epsilonImported
Submitted name:
cDNA, FLJ79275, highly similar to T-complex protein 1 subunit epsilonImported
Gene namesi
Name:CCT5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1618. CCT5.

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiB7ZAR1.

Expressioni

Gene expression databases

BgeeiENSG00000150753.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000280326.

Structurei

3D structure databases

SMRiB7ZAR1. Positions 1-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0357. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074988.
HOVERGENiHBG106507.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012718. Chap_CCT_epsi.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02343. chap_CCT_epsi. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7ZAR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKAVANTM RTSLGPNGLD KMMVDKDGDV TVTNDGATIL SMMDVDHQIA
60 70 80 90 100
KLMVELSKSQ DDEIGDGTTG VVVLAGALLE EAEQLLDRGI HPIRIADGYE
110 120 130 140 150
QAARVAIEHL DKISDSVLVD IKDTEPLIQT AKTTLGSKVV NSCHRQMAEI
160 170 180 190 200
AVNAVLTVAD MERRDVDFEL IKVEGKVGGR LEDTKLIKGV IVDKDFSHPQ
210 220 230 240 250
MPKKVEDAKI AILTCPFEPP KPKTKHKLDV TSVEDYKALQ KYEKEKFEEM
260 270 280 290 300
IQQIKETGAN LAICQWGFDD EANHLLLQNN LPAVRWVGGP EIELIAIATG
310 320 330 340 350
GRIVPRFSEL TAEKLGFAGL VQEISFGTTK DKMLVIEQCK NSRAVTIFIR
360 370 380 390 400
GGNKMIIEEA KRSLHDALCV IRNLIRDNRV VYGGGAAEIS CALAVSQEAD
410 420 430 440 450
KCPTLEQYAM RAFADALEVI PMALSENSGM NPIQTMTEVR ARQVKEMNPA
460 470 480 490 500
LGIDCLHKGT NDMKQQHVIE TLIGKKQQIS LATQMVRMIL KIDDIRKPGE

SEE
Length:503
Mass (Da):55,349
Last modified:March 3, 2009 - v1
Checksum:i1BB10D5AEA8D8849
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012640 Genomic DNA. No translation available.
AK316376 mRNA. Translation: BAH14747.1.
RefSeqiNP_001293085.1. NM_001306156.1.
UniGeneiHs.1600.
Hs.740762.

Genome annotation databases

EnsembliENST00000515676; ENSP00000427297; ENSG00000150753.
GeneIDi22948.
UCSCiuc011cms.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012640 Genomic DNA. No translation available.
AK316376 mRNA. Translation: BAH14747.1.
RefSeqiNP_001293085.1. NM_001306156.1.
UniGeneiHs.1600.
Hs.740762.

3D structure databases

SMRiB7ZAR1. Positions 1-499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000280326.

Proteomic databases

PeptideAtlasiB7ZAR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000515676; ENSP00000427297; ENSG00000150753.
GeneIDi22948.
UCSCiuc011cms.3. human.

Organism-specific databases

CTDi22948.
HGNCiHGNC:1618. CCT5.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0357. Eukaryota.
COG0459. LUCA.
GeneTreeiENSGT00550000074988.
HOVERGENiHBG106507.

Miscellaneous databases

ChiTaRSiCCT5. human.
GenomeRNAii22948.

Gene expression databases

BgeeiENSG00000150753.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012718. Chap_CCT_epsi.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02343. chap_CCT_epsi. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7ZAR1_HUMAN
AccessioniPrimary (citable) accession number: B7ZAR1
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.