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B7ZAQ6

- GPHRA_HUMAN

UniProt

B7ZAQ6 - GPHRA_HUMAN

Protein

Golgi pH regulator A

Gene

GPR89A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 2 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.By similarity

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB
    2. voltage-gated anion channel activity Source: UniProtKB

    GO - Biological processi

    1. intracellular pH reduction Source: UniProtKB
    2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    3. protein transport Source: UniProtKB-KW
    4. regulation of anion transport Source: GOC
    5. signal transduction Source: GOC

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi pH regulator A
    Alternative name(s):
    Protein GPR89A
    Putative MAPK-activating protein PM01
    Putative NF-kappa-B-activating protein 90
    Gene namesi
    Name:GPR89A
    Synonyms:GPHRA, GPR89, SH120
    ORF Names:CGI-13, UNQ192/PRO218
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:31984. GPR89A.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi-associated vesicle membrane Source: UniProtKB
    2. Golgi cisterna membrane Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134986137.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Golgi pH regulator APRO_0000223260Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiB7ZAQ6.
    PaxDbiB7ZAQ6.
    PRIDEiB7ZAQ6.

    PTM databases

    PhosphoSiteiB7ZAQ6.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    BgeeiB7ZAQ6.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    BioGridi119554. 1 interaction.
    575849. 1 interaction.
    MINTiMINT-4723292.
    STRINGi9606.ENSP00000319673.

    Structurei

    3D structure databases

    ProteinModelPortaliB7ZAQ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei46 – 6621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG295277.
    HOVERGENiHBG054909.
    PhylomeDBiB7ZAQ6.
    TreeFamiTF313484.

    Family and domain databases

    InterProiIPR025969. ABA_GPCR_dom.
    IPR022535. Golgi_pH-regulator_cons_dom.
    IPR015672. GPHR.
    [Graphical view]
    PANTHERiPTHR15948. PTHR15948. 1 hit.
    PfamiPF12430. ABA_GPCR. 1 hit.
    PF12537. DUF3735. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B7ZAQ6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF    50
    SCTMFELIIF EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS 100
    NIRLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV 150
    GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI 200
    ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG SENLTLIQQE 250
    VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK 300
    IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI 350
    IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM 400
    SMPLEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE 450
    KQMAP 455
    Length:455
    Mass (Da):52,917
    Last modified:June 15, 2010 - v2
    Checksum:iD831F66E682643F9
    GO
    Isoform 2 (identifier: B7ZAQ6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-120: Missing.

    Show »
    Length:335
    Mass (Da):38,484
    Checksum:iAC5F09C2DA129937
    GO
    Isoform 3 (identifier: B7ZAQ6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-25: Missing.

    Show »
    Length:430
    Mass (Da):49,986
    Checksum:i60065DCCB3B1A31B
    GO
    Isoform 4 (identifier: B7ZAQ6-4) [UniParc]FASTAAdd to Basket

    Also known as: A

    The sequence of this isoform differs from the canonical sequence as follows:
         106-124: HKQRLLFSCLLWLTFMYFF → LSPLSQCINNDCFFPVSYG
         125-455: Missing.

    Show »
    Length:124
    Mass (Da):14,650
    Checksum:iB2C6CE7C583F0DD2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti100 – 1001S → G in BAG63359. (PubMed:14702039)Curated
    Sequence conflicti243 – 2431N → MPD in BAD96943. 1 PublicationCurated
    Sequence conflicti379 – 3791I → T in BAD96943. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 120120Missing in isoform 2. 2 PublicationsVSP_017247Add
    BLAST
    Alternative sequencei1 – 2525Missing in isoform 3. 1 PublicationVSP_039346Add
    BLAST
    Alternative sequencei106 – 12419HKQRL…FMYFF → LSPLSQCINNDCFFPVSYG in isoform 4. 2 PublicationsVSP_055892Add
    BLAST
    Alternative sequencei125 – 455331Missing in isoform 4. 2 PublicationsVSP_055893Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132947 mRNA. Translation: AAD27722.1.
    KJ535049 mRNA. Translation: AHW56688.1.
    AY358966 mRNA. Translation: AAQ89325.1.
    AB097024 mRNA. Translation: BAC77377.1.
    AB097025 mRNA. Translation: BAC77378.1.
    BT006679 mRNA. Translation: AAP35325.1.
    AK021758 mRNA. Translation: BAG51045.1.
    AK297145 mRNA. Translation: BAG59645.1.
    AK301939 mRNA. Translation: BAG63359.1.
    AK316371 mRNA. Translation: BAH14742.1.
    AK223223 mRNA. Translation: BAD96943.1.
    AL390725, BX511042, CR628408 Genomic DNA. Translation: CAI13712.2.
    BX511042, AL390725, CR628408 Genomic DNA. Translation: CAI13224.2.
    CR628408, AL390725, BX511042 Genomic DNA. Translation: CAM28366.1.
    BC003187 mRNA. Translation: AAH03187.1.
    BC067816 mRNA. Translation: AAH67816.1.
    BC146880 mRNA. Translation: AAI46881.1.
    CCDSiCCDS41377.1. [B7ZAQ6-1]
    CCDS44207.2. [B7ZAQ6-3]
    RefSeqiNP_001091081.1. NM_001097612.1. [B7ZAQ6-1]
    NP_001091082.2. NM_001097613.2. [B7ZAQ6-3]
    NP_057418.1. NM_016334.3. [B7ZAQ6-1]
    XP_005277458.1. XM_005277401.2. [B7ZAQ6-1]
    XP_005277459.1. XM_005277402.2. [B7ZAQ6-3]
    XP_005277461.1. XM_005277404.2. [B7ZAQ6-2]
    XP_006711440.1. XM_006711377.1. [B7ZAQ6-3]
    XP_006711441.1. XM_006711378.1. [B7ZAQ6-2]
    XP_006711555.1. XM_006711492.1. [B7ZAQ6-1]
    XP_006711556.1. XM_006711493.1. [B7ZAQ6-2]
    UniGeneiHs.504320.
    Hs.559115.
    Hs.645432.

    Genome annotation databases

    EnsembliENST00000313835; ENSP00000319673; ENSG00000117262. [B7ZAQ6-1]
    ENST00000460277; ENSP00000436705; ENSG00000117262. [B7ZAQ6-4]
    ENST00000462900; ENSP00000432248; ENSG00000117262. [B7ZAQ6-3]
    ENST00000528944; ENSP00000434108; ENSG00000117262. [B7ZAQ6-4]
    ENST00000534502; ENSP00000434495; ENSG00000117262. [B7ZAQ6-3]
    GeneIDi51463.
    653519.
    KEGGihsa:51463.
    hsa:653519.
    UCSCiuc001eos.2. human. [B7ZAQ6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132947 mRNA. Translation: AAD27722.1 .
    KJ535049 mRNA. Translation: AHW56688.1 .
    AY358966 mRNA. Translation: AAQ89325.1 .
    AB097024 mRNA. Translation: BAC77377.1 .
    AB097025 mRNA. Translation: BAC77378.1 .
    BT006679 mRNA. Translation: AAP35325.1 .
    AK021758 mRNA. Translation: BAG51045.1 .
    AK297145 mRNA. Translation: BAG59645.1 .
    AK301939 mRNA. Translation: BAG63359.1 .
    AK316371 mRNA. Translation: BAH14742.1 .
    AK223223 mRNA. Translation: BAD96943.1 .
    AL390725 , BX511042 , CR628408 Genomic DNA. Translation: CAI13712.2 .
    BX511042 , AL390725 , CR628408 Genomic DNA. Translation: CAI13224.2 .
    CR628408 , AL390725 , BX511042 Genomic DNA. Translation: CAM28366.1 .
    BC003187 mRNA. Translation: AAH03187.1 .
    BC067816 mRNA. Translation: AAH67816.1 .
    BC146880 mRNA. Translation: AAI46881.1 .
    CCDSi CCDS41377.1. [B7ZAQ6-1 ]
    CCDS44207.2. [B7ZAQ6-3 ]
    RefSeqi NP_001091081.1. NM_001097612.1. [B7ZAQ6-1 ]
    NP_001091082.2. NM_001097613.2. [B7ZAQ6-3 ]
    NP_057418.1. NM_016334.3. [B7ZAQ6-1 ]
    XP_005277458.1. XM_005277401.2. [B7ZAQ6-1 ]
    XP_005277459.1. XM_005277402.2. [B7ZAQ6-3 ]
    XP_005277461.1. XM_005277404.2. [B7ZAQ6-2 ]
    XP_006711440.1. XM_006711377.1. [B7ZAQ6-3 ]
    XP_006711441.1. XM_006711378.1. [B7ZAQ6-2 ]
    XP_006711555.1. XM_006711492.1. [B7ZAQ6-1 ]
    XP_006711556.1. XM_006711493.1. [B7ZAQ6-2 ]
    UniGenei Hs.504320.
    Hs.559115.
    Hs.645432.

    3D structure databases

    ProteinModelPortali B7ZAQ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119554. 1 interaction.
    575849. 1 interaction.
    MINTi MINT-4723292.
    STRINGi 9606.ENSP00000319673.

    PTM databases

    PhosphoSitei B7ZAQ6.

    Proteomic databases

    MaxQBi B7ZAQ6.
    PaxDbi B7ZAQ6.
    PRIDEi B7ZAQ6.

    Protocols and materials databases

    DNASUi 51463.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313835 ; ENSP00000319673 ; ENSG00000117262 . [B7ZAQ6-1 ]
    ENST00000460277 ; ENSP00000436705 ; ENSG00000117262 . [B7ZAQ6-4 ]
    ENST00000462900 ; ENSP00000432248 ; ENSG00000117262 . [B7ZAQ6-3 ]
    ENST00000528944 ; ENSP00000434108 ; ENSG00000117262 . [B7ZAQ6-4 ]
    ENST00000534502 ; ENSP00000434495 ; ENSG00000117262 . [B7ZAQ6-3 ]
    GeneIDi 51463.
    653519.
    KEGGi hsa:51463.
    hsa:653519.
    UCSCi uc001eos.2. human. [B7ZAQ6-1 ]

    Organism-specific databases

    CTDi 51463.
    653519.
    GeneCardsi GC01M145764.
    HGNCi HGNC:31984. GPR89A.
    MIMi 612821. gene.
    neXtProti NX_B7ZAQ6.
    PharmGKBi PA134986137.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295277.
    HOVERGENi HBG054909.
    PhylomeDBi B7ZAQ6.
    TreeFami TF313484.

    Miscellaneous databases

    ChiTaRSi GPR89A. human.
    GeneWikii GPR89B.
    NextBioi 55087.
    PROi B7ZAQ6.
    SOURCEi Search...

    Gene expression databases

    Bgeei B7ZAQ6.

    Family and domain databases

    InterProi IPR025969. ABA_GPCR_dom.
    IPR022535. Golgi_pH-regulator_cons_dom.
    IPR015672. GPHR.
    [Graphical view ]
    PANTHERi PTHR15948. PTHR15948. 1 hit.
    Pfami PF12430. ABA_GPCR. 1 hit.
    PF12537. DUF3735. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
      Corominas R., Yang X., Lin G.N., Kang S., Shen Y., Ghamsari L., Broly M., Rodriguez M., Tam S., Wanamaker S.A., Fan C., Yi S., Tasan M., Lemmens I., Kuang X., Zhao N., Malhotra D., Michaelson J.J.
      , Vacic V., Calderwood M.A., Roth F.P., Tavernier J., Horvath S., Salehi-Ashtiani K., Korkin D., Sebat J., Hill D.E., Hao T., Vidal M., Iakoucheva L.M.
      Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
      Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), FUNCTION.
      Tissue: Lung fibroblast.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
      Tissue: Embryo and Testis.
    7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Gastric mucosa.
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain, Lung and Testis.
    10. "GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus."
      Maeda Y., Ide T., Koike M., Uchiyama Y., Kinoshita T.
      Nat. Cell Biol. 10:1135-1145(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY.
    11. "Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis."
      Pandey S., Nelson D.C., Assmann S.M.
      Cell 136:136-148(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF GTP-BINDING.

    Entry informationi

    Entry nameiGPHRA_HUMAN
    AccessioniPrimary (citable) accession number: B7ZAQ6
    Secondary accession number(s): A6NN37
    , B2RUV3, B3KMN3, B4DLT3, B4DXE7, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 44 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Does not seem to be able to bind GTP.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3