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Protein

Golgi pH regulator A

Gene

GPR89A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.By similarity

GO - Molecular functioni

  • signal transducer activity Source: UniProtKB
  • voltage-gated anion channel activity Source: UniProtKB

GO - Biological processi

  • intracellular pH reduction Source: UniProtKB
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • regulation of anion transmembrane transport Source: GOC
  • signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi pH regulator A
Alternative name(s):
Protein GPR89A
Putative MAPK-activating protein PM01
Putative NF-kappa-B-activating protein 90
Gene namesi
Name:GPR89A
Synonyms:GPHRA, GPR89, SH120
ORF Names:CGI-13, UNQ192/PRO218
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31984. GPR89A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • Golgi-associated vesicle membrane Source: UniProtKB
  • Golgi cisterna membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134986137.

Polymorphism and mutation databases

BioMutaiGPR89A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Golgi pH regulator APRO_0000223260Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiB7ZAQ6.
PRIDEiB7ZAQ6.

PTM databases

PhosphoSiteiB7ZAQ6.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiB7ZAQ6.
ExpressionAtlasiB7ZAQ6. baseline.
GenevisibleiB7ZAQ6. HS.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi119554. 9 interactions.
575849. 16 interactions.
MINTiMINT-4723292.
STRINGi9606.ENSP00000358233.

Structurei

3D structure databases

ProteinModelPortaliB7ZAQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295277.
GeneTreeiENSGT00390000000684.
HOVERGENiHBG054909.
InParanoidiB7ZAQ6.
OrthoDBiEOG7HHWRV.
PhylomeDBiB7ZAQ6.
TreeFamiTF313484.

Family and domain databases

InterProiIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR/GTG.
[Graphical view]
PANTHERiPTHR15948. PTHR15948. 1 hit.
PfamiPF12430. ABA_GPCR. 1 hit.
PF12537. DUF3735. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B7ZAQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF
60 70 80 90 100
SCTMFELIIF EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS
110 120 130 140 150
NIRLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV
160 170 180 190 200
GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI
210 220 230 240 250
ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG SENLTLIQQE
260 270 280 290 300
VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK
310 320 330 340 350
IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI
360 370 380 390 400
IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM
410 420 430 440 450
SMPLEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE

KQMAP
Length:455
Mass (Da):52,917
Last modified:June 15, 2010 - v2
Checksum:iD831F66E682643F9
GO
Isoform 2 (identifier: B7ZAQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.

Show »
Length:335
Mass (Da):38,484
Checksum:iAC5F09C2DA129937
GO
Isoform 3 (identifier: B7ZAQ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Show »
Length:430
Mass (Da):49,986
Checksum:i60065DCCB3B1A31B
GO
Isoform 4 (identifier: B7ZAQ6-4) [UniParc]FASTAAdd to basket

Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     106-124: HKQRLLFSCLLWLTFMYFF → LSPLSQCINNDCFFPVSYG
     125-455: Missing.

Show »
Length:124
Mass (Da):14,650
Checksum:iB2C6CE7C583F0DD2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001S → G in BAG63359 (PubMed:14702039).Curated
Sequence conflicti243 – 2431N → MPD in BAD96943 (Ref. 7) Curated
Sequence conflicti379 – 3791I → T in BAD96943 (Ref. 7) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 120120Missing in isoform 2. 2 PublicationsVSP_017247Add
BLAST
Alternative sequencei1 – 2525Missing in isoform 3. 1 PublicationVSP_039346Add
BLAST
Alternative sequencei106 – 12419HKQRL…FMYFF → LSPLSQCINNDCFFPVSYG in isoform 4. 2 PublicationsVSP_055892Add
BLAST
Alternative sequencei125 – 455331Missing in isoform 4. 2 PublicationsVSP_055893Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132947 mRNA. Translation: AAD27722.1.
KJ535049 mRNA. Translation: AHW56688.1.
AY358966 mRNA. Translation: AAQ89325.1.
AB097024 mRNA. Translation: BAC77377.1.
AB097025 mRNA. Translation: BAC77378.1.
BT006679 mRNA. Translation: AAP35325.1.
AK021758 mRNA. Translation: BAG51045.1.
AK297145 mRNA. Translation: BAG59645.1.
AK301939 mRNA. Translation: BAG63359.1.
AK316371 mRNA. Translation: BAH14742.1.
AK223223 mRNA. Translation: BAD96943.1.
AL390725, BX511042, CR628408 Genomic DNA. Translation: CAI13712.2.
BX511042, AL390725, CR628408 Genomic DNA. Translation: CAI13224.2.
CR628408, AL390725, BX511042 Genomic DNA. Translation: CAM28366.1.
BC003187 mRNA. Translation: AAH03187.1.
BC067816 mRNA. Translation: AAH67816.1.
BC146880 mRNA. Translation: AAI46881.1.
CCDSiCCDS72857.1. [B7ZAQ6-1]
CCDS72858.1. [B7ZAQ6-3]
RefSeqiNP_001091081.1. NM_001097612.1. [B7ZAQ6-1]
NP_001091082.2. NM_001097613.2. [B7ZAQ6-3]
NP_057418.1. NM_016334.3. [B7ZAQ6-1]
XP_005277458.1. XM_005277401.2. [B7ZAQ6-1]
XP_005277459.1. XM_005277402.3. [B7ZAQ6-3]
XP_005277461.1. XM_005277404.2. [B7ZAQ6-2]
XP_006711440.1. XM_006711377.2. [B7ZAQ6-3]
XP_006711441.1. XM_006711378.1. [B7ZAQ6-2]
XP_006711555.1. XM_006711492.2. [B7ZAQ6-1]
XP_006711556.1. XM_006711493.2. [B7ZAQ6-2]
XP_011507912.1. XM_011509610.1. [B7ZAQ6-3]
XP_011507914.1. XM_011509612.1. [B7ZAQ6-2]
XP_011508210.1. XM_011509908.1. [B7ZAQ6-3]
XP_011508211.1. XM_011509909.1. [B7ZAQ6-3]
UniGeneiHs.504320.
Hs.559115.
Hs.645432.

Genome annotation databases

EnsembliENST00000460277; ENSP00000436705; ENSG00000117262. [B7ZAQ6-4]
ENST00000462900; ENSP00000432248; ENSG00000117262. [B7ZAQ6-3]
ENST00000528944; ENSP00000434108; ENSG00000117262. [B7ZAQ6-4]
ENST00000534502; ENSP00000434495; ENSG00000117262. [B7ZAQ6-3]
GeneIDi51463.
653519.
KEGGihsa:51463.
hsa:653519.
UCSCiuc001eos.2. human. [B7ZAQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132947 mRNA. Translation: AAD27722.1.
KJ535049 mRNA. Translation: AHW56688.1.
AY358966 mRNA. Translation: AAQ89325.1.
AB097024 mRNA. Translation: BAC77377.1.
AB097025 mRNA. Translation: BAC77378.1.
BT006679 mRNA. Translation: AAP35325.1.
AK021758 mRNA. Translation: BAG51045.1.
AK297145 mRNA. Translation: BAG59645.1.
AK301939 mRNA. Translation: BAG63359.1.
AK316371 mRNA. Translation: BAH14742.1.
AK223223 mRNA. Translation: BAD96943.1.
AL390725, BX511042, CR628408 Genomic DNA. Translation: CAI13712.2.
BX511042, AL390725, CR628408 Genomic DNA. Translation: CAI13224.2.
CR628408, AL390725, BX511042 Genomic DNA. Translation: CAM28366.1.
BC003187 mRNA. Translation: AAH03187.1.
BC067816 mRNA. Translation: AAH67816.1.
BC146880 mRNA. Translation: AAI46881.1.
CCDSiCCDS72857.1. [B7ZAQ6-1]
CCDS72858.1. [B7ZAQ6-3]
RefSeqiNP_001091081.1. NM_001097612.1. [B7ZAQ6-1]
NP_001091082.2. NM_001097613.2. [B7ZAQ6-3]
NP_057418.1. NM_016334.3. [B7ZAQ6-1]
XP_005277458.1. XM_005277401.2. [B7ZAQ6-1]
XP_005277459.1. XM_005277402.3. [B7ZAQ6-3]
XP_005277461.1. XM_005277404.2. [B7ZAQ6-2]
XP_006711440.1. XM_006711377.2. [B7ZAQ6-3]
XP_006711441.1. XM_006711378.1. [B7ZAQ6-2]
XP_006711555.1. XM_006711492.2. [B7ZAQ6-1]
XP_006711556.1. XM_006711493.2. [B7ZAQ6-2]
XP_011507912.1. XM_011509610.1. [B7ZAQ6-3]
XP_011507914.1. XM_011509612.1. [B7ZAQ6-2]
XP_011508210.1. XM_011509908.1. [B7ZAQ6-3]
XP_011508211.1. XM_011509909.1. [B7ZAQ6-3]
UniGeneiHs.504320.
Hs.559115.
Hs.645432.

3D structure databases

ProteinModelPortaliB7ZAQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119554. 9 interactions.
575849. 16 interactions.
MINTiMINT-4723292.
STRINGi9606.ENSP00000358233.

PTM databases

PhosphoSiteiB7ZAQ6.

Polymorphism and mutation databases

BioMutaiGPR89A.

Proteomic databases

PaxDbiB7ZAQ6.
PRIDEiB7ZAQ6.

Protocols and materials databases

DNASUi51463.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000460277; ENSP00000436705; ENSG00000117262. [B7ZAQ6-4]
ENST00000462900; ENSP00000432248; ENSG00000117262. [B7ZAQ6-3]
ENST00000528944; ENSP00000434108; ENSG00000117262. [B7ZAQ6-4]
ENST00000534502; ENSP00000434495; ENSG00000117262. [B7ZAQ6-3]
GeneIDi51463.
653519.
KEGGihsa:51463.
hsa:653519.
UCSCiuc001eos.2. human. [B7ZAQ6-1]

Organism-specific databases

CTDi51463.
653519.
GeneCardsiGC01M145764.
HGNCiHGNC:31984. GPR89A.
MIMi612821. gene.
neXtProtiNX_B7ZAQ6.
PharmGKBiPA134986137.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG295277.
GeneTreeiENSGT00390000000684.
HOVERGENiHBG054909.
InParanoidiB7ZAQ6.
OrthoDBiEOG7HHWRV.
PhylomeDBiB7ZAQ6.
TreeFamiTF313484.

Miscellaneous databases

ChiTaRSiGPR89A. human.
GeneWikiiGPR89B.
NextBioi123370.
PROiB7ZAQ6.
SOURCEiSearch...

Gene expression databases

BgeeiB7ZAQ6.
ExpressionAtlasiB7ZAQ6. baseline.
GenevisibleiB7ZAQ6. HS.

Family and domain databases

InterProiIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR/GTG.
[Graphical view]
PANTHERiPTHR15948. PTHR15948. 1 hit.
PfamiPF12430. ABA_GPCR. 1 hit.
PF12537. DUF3735. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
    Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y., Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.
    Oncogene 22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), FUNCTION.
    Tissue: Lung fibroblast.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Embryo and Testis.
  7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Gastric mucosa.
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Lung and Testis.
  10. "GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus."
    Maeda Y., Ide T., Koike M., Uchiyama Y., Kinoshita T.
    Nat. Cell Biol. 10:1135-1145(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY.
  11. "Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis."
    Pandey S., Nelson D.C., Assmann S.M.
    Cell 136:136-148(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF GTP-BINDING.

Entry informationi

Entry nameiGPHRA_HUMAN
AccessioniPrimary (citable) accession number: B7ZAQ6
Secondary accession number(s): A6NN37
, B2RUV3, B3KMN3, B4DLT3, B4DXE7, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 22, 2015
This is version 51 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Does not seem to be able to bind GTP.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.