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Protein

Rab GTPase-activating protein 1-like, isoform 10

Gene

RABGAP1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GTPase-activating protein 1-like, isoform 10
Gene namesi
Name:RABGAP1L
Synonyms:HHL, KIAA0471
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24663. RABGAP1L.

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiCACNA1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253Rab GTPase-activating protein 1-like, isoform 10PRO_0000417613Add
BLAST

Proteomic databases

EPDiB7ZAP0.
PRIDEiB7ZAP0.

Expressioni

Gene expression databases

BgeeiB7ZAP0.
ExpressionAtlasiB7ZAP0. baseline and differential.
GenevisibleiB7ZAP0. HS.

Interactioni

Protein-protein interaction databases

BioGridi115239. 42 interactions.

Structurei

3D structure databases

ProteinModelPortaliB7ZAP0.
SMRiB7ZAP0. Positions 4-46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 222215Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00750000117238.
HOVERGENiHBG068503.
OrthoDBiEOG751NDS.

Sequences (10)i

Sequence statusi: Complete.

This entry describes 10 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 10 (identifier: B7ZAP0-1) [UniParc]FASTAAdd to basket

Also known as: D

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIENSSWSMT FEERENRRLQ EASMRLEQEN DDLAHELVTS KIALRNDLDQ
60 70 80 90 100
AEDKADVLNK ELLLTKQRLV ETEEEKRKQE EETAQLKEVF RKQLEKAEYE
110 120 130 140 150
IKKTTAIIAE YKQICSQLST RLEKQQAASK EELEVVKGKM MACKHCSDIF
160 170 180 190 200
SKEGALKLAA TGREDQGIET DDEKDSLKKQ LREMELELAQ TKLQLVEAKC
210 220 230 240 250
KIQELEHQRG ALMNEIQAAK NSWFSKTLNS IKTATGTQPL QPAPVTQPPK

EST
Length:253
Mass (Da):29,038
Last modified:March 3, 2009 - v1
Checksum:i3F7A7E4D6197856C
GO
Isoform 1 (identifier: Q5R372-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:815
Mass (Da):92,513
GO
Isoform 2 (identifier: Q5R372-2) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:605
Mass (Da):68,003
GO
Isoform 3 (identifier: Q5R372-3) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:827
Mass (Da):94,002
GO
Isoform 4 (identifier: Q5R372-4) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:800
Mass (Da):90,838
GO
Isoform 5 (identifier: Q5R372-5) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:378
Mass (Da):43,888
GO
Isoform 6 (identifier: Q5R372-6) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:377
Mass (Da):43,760
GO
Isoform 7 (identifier: Q5R372-7) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:358
Mass (Da):41,545
GO
Isoform 8 (identifier: Q5R372-8) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:370
Mass (Da):42,689
GO
Isoform 9 (identifier: Q5R372-9) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q5R372.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:72
Mass (Da):8,667
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891V → A in BAH14590 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316219 mRNA. Translation: BAH14590.1.
AK316355 mRNA. Translation: BAH14726.1.
AL008735 Genomic DNA. No translation available.
AL021069 Genomic DNA. No translation available.
AL022171 Genomic DNA. No translation available.
AL022400 Genomic DNA. No translation available.
AL031278 Genomic DNA. No translation available.
AL031286 Genomic DNA. No translation available.
AL136377 Genomic DNA. No translation available.
AL161671 Genomic DNA. No translation available.
AL591108 Genomic DNA. No translation available.
Z99127 Genomic DNA. No translation available.
CCDSiCCDS55662.1. [B7ZAP0-1]
RefSeqiNP_001230693.1. NM_001243764.1. [B7ZAP0-1]
UniGeneiHs.585378.
Hs.744937.

Genome annotation databases

EnsembliENST00000367688; ENSP00000356661; ENSG00000152061. [B7ZAP0-1]
GeneIDi9910.
UCSCiuc010pmv.3. human. [B7ZAP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK316219 mRNA. Translation: BAH14590.1.
AK316355 mRNA. Translation: BAH14726.1.
AL008735 Genomic DNA. No translation available.
AL021069 Genomic DNA. No translation available.
AL022171 Genomic DNA. No translation available.
AL022400 Genomic DNA. No translation available.
AL031278 Genomic DNA. No translation available.
AL031286 Genomic DNA. No translation available.
AL136377 Genomic DNA. No translation available.
AL161671 Genomic DNA. No translation available.
AL591108 Genomic DNA. No translation available.
Z99127 Genomic DNA. No translation available.
CCDSiCCDS55662.1. [B7ZAP0-1]
RefSeqiNP_001230693.1. NM_001243764.1. [B7ZAP0-1]
UniGeneiHs.585378.
Hs.744937.

3D structure databases

ProteinModelPortaliB7ZAP0.
SMRiB7ZAP0. Positions 4-46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115239. 42 interactions.

Polymorphism and mutation databases

BioMutaiCACNA1B.

Proteomic databases

EPDiB7ZAP0.
PRIDEiB7ZAP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367688; ENSP00000356661; ENSG00000152061. [B7ZAP0-1]
GeneIDi9910.
UCSCiuc010pmv.3. human. [B7ZAP0-1]

Organism-specific databases

CTDi9910.
GeneCardsiRABGAP1L.
HGNCiHGNC:24663. RABGAP1L.
neXtProtiNX_B7ZAP0.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00750000117238.
HOVERGENiHBG068503.
OrthoDBiEOG751NDS.

Miscellaneous databases

ChiTaRSiRABGAP1L. human.
GenomeRNAii9910.

Gene expression databases

BgeeiB7ZAP0.
ExpressionAtlasiB7ZAP0. baseline and differential.
GenevisibleiB7ZAP0. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10).
    Tissue: Synovial cell.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRBG10_HUMAN
AccessioniPrimary (citable) accession number: B7ZAP0
Secondary accession number(s): B7ZAA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: March 3, 2009
Last modified: June 8, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.