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Protein
Submitted name:

Breast cancer type 1 susceptibility protein

Gene

BRCA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Breast cancer type 1 susceptibility proteinImported
Submitted name:
cDNA, FLJ79099, highly similar to Homo sapiens breast cancer 1, early onset (BRCA1), transcript variant BRCA1-delta 11b, mRNAImported
Gene namesi
Name:BRCA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:1100. BRCA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiB7ZA85.

Expressioni

Gene expression databases

BgeeiENSG00000012048.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000418960.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini492 – 57281BRCTInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili247 – 27428Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410ITQ4. Eukaryota.
ENOG4112BIH. LUCA.
GeneTreeiENSGT00440000034289.
HOGENOMiHOG000142477.
HOVERGENiHBG061757.

Family and domain databases

Gene3Di3.40.50.10190. 1 hit.
InterProiIPR011364. BRCA1.
IPR031099. BRCA1-associated.
IPR001357. BRCT_dom.
[Graphical view]
PANTHERiPTHR13763. PTHR13763. 1 hit.
PTHR13763:SF0. PTHR13763:SF0. 1 hit.
PfamiPF00533. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B7ZA85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLLNQKKG PSQCPLCKND ITKRSLQEST RFSQLVEELL KIICAFQLDT
60 70 80 90 100
GLEYANSYNF AKKENNSPEH LKDEVSIIQS MGYRNRAKRL LQSEPENPSL
110 120 130 140 150
QETSLSVQLS NLGTVRTLRT KQRIQPQKTS VYIELGSDSS EDTVNKATYC
160 170 180 190 200
SVGDQELLQI TPQGTRDEIS LDSAKKAACE FSETDVTNTE HHQPSNNDLN
210 220 230 240 250
TTEKRAAERH PEKYQGEAAS GCESETSVSE DCSGLSSQSD ILTTQQRDTM
260 270 280 290 300
QHNLIKLQQE MAELEAVLEQ HGSQPSNSYP SIISDSSALE DLRNPEQSTS
310 320 330 340 350
EKAVLTSQKS SEYPISQNPE GLSADKFEVS ADSSTSKNKE PGVERSSPSK
360 370 380 390 400
CPSLDDRWYM HSCSGSLQNR NYPSQEELIK VVDVEEQQLE ESGPHDLTET
410 420 430 440 450
SYLPRQDLEG TPYLESGISL FSDDPESDPS EDRAPESARV GNIPSSTSAL
460 470 480 490 500
KVPQLKVAES AQSPAAAHTT DTAGYNAMEE SVSREKPELT ASTERVNKRM
510 520 530 540 550
SMVVSGLTPE EFMLVYKFAR KHHITLTNLI TEETTHVVMK TDAEFVCERT
560 570
LKYFLGIAGG KWVVSYFWVT QS
Length:572
Mass (Da):63,612
Last modified:March 3, 2009 - v1
Checksum:i87C5EE641D2C1611
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei572 – 5721Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC060780 Genomic DNA. No translation available.
AC135721 Genomic DNA. No translation available.
KF456281 Genomic DNA. No translation available.
AK316200 mRNA. Translation: BAH14571.1.
UniGeneiHs.194143.

Genome annotation databases

EnsembliENST00000493919; ENSP00000418819; ENSG00000012048.
UCSCiuc060fro.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC060780 Genomic DNA. No translation available.
AC135721 Genomic DNA. No translation available.
KF456281 Genomic DNA. No translation available.
AK316200 mRNA. Translation: BAH14571.1.
UniGeneiHs.194143.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000418960.

Proteomic databases

PeptideAtlasiB7ZA85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000493919; ENSP00000418819; ENSG00000012048.
UCSCiuc060fro.1. human.

Organism-specific databases

HGNCiHGNC:1100. BRCA1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITQ4. Eukaryota.
ENOG4112BIH. LUCA.
GeneTreeiENSGT00440000034289.
HOGENOMiHOG000142477.
HOVERGENiHBG061757.

Miscellaneous databases

ChiTaRSiBRCA1. human.

Gene expression databases

BgeeiENSG00000012048.

Family and domain databases

Gene3Di3.40.50.10190. 1 hit.
InterProiIPR011364. BRCA1.
IPR031099. BRCA1-associated.
IPR001357. BRCT_dom.
[Graphical view]
PANTHERiPTHR13763. PTHR13763. 1 hit.
PTHR13763:SF0. PTHR13763:SF0. 1 hit.
PfamiPF00533. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7ZA85_HUMAN
AccessioniPrimary (citable) accession number: B7ZA85
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.