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Protein
Submitted name:

Breast cancer type 1 susceptibility protein

Gene

BRCA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Breast cancer type 1 susceptibility proteinImported
Submitted name:
cDNA, FLJ79099, highly similar to Homo sapiens breast cancer 1, early onset (BRCA1), transcript variant BRCA1-delta 11b, mRNAImported
Gene namesi
Name:BRCA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000012048.20
HGNCiHGNC:1100 BRCA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000012048

PTM / Processingi

Proteomic databases

MaxQBiB7ZA85
PeptideAtlasiB7ZA85
PRIDEiB7ZA85

Expressioni

Gene expression databases

BgeeiENSG00000012048
ExpressionAtlasiB7ZA85 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini492 – 572BRCTInterPro annotationAdd BLAST81

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili247 – 274Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410ITQ4 Eukaryota
ENOG4112BIH LUCA
GeneTreeiENSGT00440000034289
HOGENOMiHOG000142477
HOVERGENiHBG061757

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di3.30.40.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR011364 BRCA1
IPR031099 BRCA1-associated
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR13763 PTHR13763, 2 hits
PTHR13763:SF0 PTHR13763:SF0, 2 hits
PfamiView protein in Pfam
PF00533 BRCT, 1 hit
PIRSFiPIRSF001734 BRCA1, 2 hits
SUPFAMiSSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit

Sequencei

Sequence statusi: Fragment.

B7ZA85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLLNQKKG PSQCPLCKND ITKRSLQEST RFSQLVEELL KIICAFQLDT
60 70 80 90 100
GLEYANSYNF AKKENNSPEH LKDEVSIIQS MGYRNRAKRL LQSEPENPSL
110 120 130 140 150
QETSLSVQLS NLGTVRTLRT KQRIQPQKTS VYIELGSDSS EDTVNKATYC
160 170 180 190 200
SVGDQELLQI TPQGTRDEIS LDSAKKAACE FSETDVTNTE HHQPSNNDLN
210 220 230 240 250
TTEKRAAERH PEKYQGEAAS GCESETSVSE DCSGLSSQSD ILTTQQRDTM
260 270 280 290 300
QHNLIKLQQE MAELEAVLEQ HGSQPSNSYP SIISDSSALE DLRNPEQSTS
310 320 330 340 350
EKAVLTSQKS SEYPISQNPE GLSADKFEVS ADSSTSKNKE PGVERSSPSK
360 370 380 390 400
CPSLDDRWYM HSCSGSLQNR NYPSQEELIK VVDVEEQQLE ESGPHDLTET
410 420 430 440 450
SYLPRQDLEG TPYLESGISL FSDDPESDPS EDRAPESARV GNIPSSTSAL
460 470 480 490 500
KVPQLKVAES AQSPAAAHTT DTAGYNAMEE SVSREKPELT ASTERVNKRM
510 520 530 540 550
SMVVSGLTPE EFMLVYKFAR KHHITLTNLI TEETTHVVMK TDAEFVCERT
560 570
LKYFLGIAGG KWVVSYFWVT QS
Length:572
Mass (Da):63,612
Last modified:March 3, 2009 - v1
Checksum:i87C5EE641D2C1611
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei572Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC060780 Genomic DNA No translation available.
AC135721 Genomic DNA No translation available.
KF456281 Genomic DNA No translation available.
AK316200 mRNA Translation: BAH14571.1
UniGeneiHs.194143

Genome annotation databases

EnsembliENST00000493919; ENSP00000418819; ENSG00000012048
UCSCiuc060fro.1 human

Similar proteinsi

Entry informationi

Entry nameiB7ZA85_HUMAN
AccessioniPrimary (citable) accession number: B7ZA85
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 20, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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