B7Z9J8 (B7Z9J8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Ensembl ENSP00000387506

Submitted name:
cDNA, FLJ78862, highly similar to Isocitrate dehydrogenase EMBL BAH14334.1
Submitted name:
cDNA, FLJ78950, highly similar to Isocitrate dehydrogenase EMBL BAH14422.1

Gene names

Name:

IDH3A Ensembl ENSP00000387506

Organism

Homo sapiens (Human) [Reference proteome] EMBL BAH14334.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU004444
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from direct assay. Source: HPA
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B7Z9J8 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: C6EB9E5007465DC8	FASTA	257	28,134
	10 20 30 40 50 60 MNLLLRKTFD LYANVRPCVS IEGYKTPYTD VNIVTIRENT EGEYSGIEHV IVDGVVQSIK 70 80 90 100 110 120 LITEGASKRI AEFAFEYARN NHRSNVTAVH KANIMRMSDG LFLQKCREVA ESCKDIKFNE 130 140 150 160 170 180 MYLDTVCLNM VQDPSQFDVL VMPNLYGDIL SDLCAGLIGG LGVTPSGNIG ANGVAIFESV 190 200 210 220 230 240 HGTAPDIAGK DMANPTALLL SAVMMLRHMG LFDHAARIEA ACFATIKDGK SLTKDLGGNA 250 KCSDFTEEIC RRVKDLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"NEDO human cDNA sequencing project." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Amygdala EMBL BAH14334.1 and Hippocampus EMBL BAH14422.1.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC090260 Genomic DNA. No translation available. AK315963 mRNA. Translation: BAH14334.1. AK316051 mRNA. Translation: BAH14422.1.
IPI	IPI00921820.
UniGene	Hs.591110.
3D structure databases
SMR	B7Z9J8. Positions 1-253.
ModBase	Search...
Proteomic databases
PRIDE	B7Z9J8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000441490; ENSP00000387506; ENSG00000166411.
Organism-specific databases
HGNC	HGNC:5384. IDH3A.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG052080.
Gene expression databases
ArrayExpress	B7Z9J8.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
PANTHER	PTHR11835. PTHR11835. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35480743.

Entry information

Entry name

B7Z9J8_HUMAN

Accession

Primary (citable) accession number: B7Z9J8
Secondary accession number(s): E7EWD2

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.