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B7Z9J8

- B7Z9J8_HUMAN

UniProt

B7Z9J8 - B7Z9J8_HUMAN

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Protein
Submitted name:

cDNA, FLJ78862, highly similar to Isocitrate dehydrogenase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. NAD binding Source: InterPro
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA, FLJ78862, highly similar to Isocitrate dehydrogenaseImported
Submitted name:
cDNA, FLJ78950, highly similar to Isocitrate dehydrogenaseImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiB7Z9J8. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB7Z9J8.
SMRiB7Z9J8. Positions 1-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG052080.
KOiK00030.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z9J8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLLLRKTFD LYANVRPCVS IEGYKTPYTD VNIVTIRENT EGEYSGIEHV
60 70 80 90 100
IVDGVVQSIK LITEGASKRI AEFAFEYARN NHRSNVTAVH KANIMRMSDG
110 120 130 140 150
LFLQKCREVA ESCKDIKFNE MYLDTVCLNM VQDPSQFDVL VMPNLYGDIL
160 170 180 190 200
SDLCAGLIGG LGVTPSGNIG ANGVAIFESV HGTAPDIAGK DMANPTALLL
210 220 230 240 250
SAVMMLRHMG LFDHAARIEA ACFATIKDGK SLTKDLGGNA KCSDFTEEIC

RRVKDLD
Length:257
Mass (Da):28,134
Last modified:March 3, 2009 - v1
Checksum:iC6EB9E5007465DC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315963 mRNA. Translation: BAH14334.1.
AK316051 mRNA. Translation: BAH14422.1.
RefSeqiXP_005254393.1. XM_005254336.1.
XP_005254394.1. XM_005254337.1.
UniGeneiHs.591110.

Genome annotation databases

GeneIDi3419.
KEGGihsa:3419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315963 mRNA. Translation: BAH14334.1 .
AK316051 mRNA. Translation: BAH14422.1 .
RefSeqi XP_005254393.1. XM_005254336.1.
XP_005254394.1. XM_005254337.1.
UniGenei Hs.591110.

3D structure databases

ProteinModelPortali B7Z9J8.
SMRi B7Z9J8. Positions 1-253.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3419.
KEGGi hsa:3419.

Organism-specific databases

CTDi 3419.

Phylogenomic databases

HOVERGENi HBG052080.
KOi K00030.

Miscellaneous databases

ChiTaRSi IDH3A. human.
GenomeRNAii 3419.
NextBioi 35480743.

Gene expression databases

ExpressionAtlasi B7Z9J8. baseline and differential.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AmygdalaImported and HippocampusImported.

Entry informationi

Entry nameiB7Z9J8_HUMAN
AccessioniPrimary (citable) accession number: B7Z9J8
Secondary accession number(s): E7EWD2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.