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B7Z9J8

- B7Z9J8_HUMAN

UniProt

B7Z9J8 - B7Z9J8_HUMAN

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Protein
Submitted name:

Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Gene
IDH3A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. NAD binding Source: InterPro
  3. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialImported
Submitted name:
cDNA, FLJ78862, highly similar to Isocitrate dehydrogenaseImported
Submitted name:
cDNA, FLJ78950, highly similar to Isocitrate dehydrogenaseImported
Gene namesi
Name:IDH3AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:5384. IDH3A.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: HPA
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliB7Z9J8.
SMRiB7Z9J8. Positions 1-253.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG052080.
KOiK00030.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z9J8-1 [UniParc]FASTAAdd to Basket

« Hide

MNLLLRKTFD LYANVRPCVS IEGYKTPYTD VNIVTIRENT EGEYSGIEHV    50
IVDGVVQSIK LITEGASKRI AEFAFEYARN NHRSNVTAVH KANIMRMSDG 100
LFLQKCREVA ESCKDIKFNE MYLDTVCLNM VQDPSQFDVL VMPNLYGDIL 150
SDLCAGLIGG LGVTPSGNIG ANGVAIFESV HGTAPDIAGK DMANPTALLL 200
SAVMMLRHMG LFDHAARIEA ACFATIKDGK SLTKDLGGNA KCSDFTEEIC 250
RRVKDLD 257
Length:257
Mass (Da):28,134
Last modified:March 3, 2009 - v1
Checksum:iC6EB9E5007465DC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC090260 Genomic DNA. No translation available.
AK315963 mRNA. Translation: BAH14334.1.
AK316051 mRNA. Translation: BAH14422.1.
RefSeqiXP_005254393.1. XM_005254336.1.
XP_005254394.1. XM_005254337.1.
UniGeneiHs.591110.

Genome annotation databases

EnsembliENST00000441490; ENSP00000387506; ENSG00000166411.
GeneIDi3419.
KEGGihsa:3419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC090260 Genomic DNA. No translation available.
AK315963 mRNA. Translation: BAH14334.1 .
AK316051 mRNA. Translation: BAH14422.1 .
RefSeqi XP_005254393.1. XM_005254336.1.
XP_005254394.1. XM_005254337.1.
UniGenei Hs.591110.

3D structure databases

ProteinModelPortali B7Z9J8.
SMRi B7Z9J8. Positions 1-253.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000441490 ; ENSP00000387506 ; ENSG00000166411 .
GeneIDi 3419.
KEGGi hsa:3419.

Organism-specific databases

CTDi 3419.
HGNCi HGNC:5384. IDH3A.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG052080.
KOi K00030.

Miscellaneous databases

GenomeRNAii 3419.
NextBioi 35480743.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: AmygdalaImported and HippocampusImported.
  3. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB7Z9J8_HUMAN
AccessioniPrimary (citable) accession number: B7Z9J8
Secondary accession number(s): E7EWD2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 9, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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