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Protein
Submitted name:

cDNA FLJ51769, highly similar to Ras GTPase-activating-like protein IQGAP2

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
cDNA FLJ51769, highly similar to Ras GTPase-activating-like protein IQGAP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiB7Z7U6.
PeptideAtlasiB7Z7U6.
PRIDEiB7Z7U6.

Interactioni

Protein-protein interaction databases

IntActiB7Z7U6. 1 interaction.
STRINGi9606.ENSP00000274364.

Structurei

3D structure databases

ProteinModelPortaliB7Z7U6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 106106Actin-bindingInterPro annotationAdd
BLAST
Domaini544 – 57734WWInterPro annotationAdd
BLAST
Domaini867 – 1100234Ras-GAPInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili115 – 14228Sequence analysisAdd
BLAST
Coiled coili1361 – 138828Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2128. Eukaryota.
COG5261. LUCA.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
KOiK05767.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B7Z7U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVCLVEELP PTTVLEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY
60 70 80 90 100
KKSGLHFRHT DNTVQWLRAM ESIGLPKIFY PETTDVYDRK NIPRMIYCIH
110 120 130 140 150
ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPSFSKIG
160 170 180 190 200
GILANELSVD EAALHAAVIA INEAVEKGIA EQTVVTLRNP NAVLTLVDDN
210 220 230 240 250
LAPEHQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK
260 270 280 290 300
VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN
310 320 330 340 350
LQKQNTMNYL AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPAIG
360 370 380 390 400
LNNLDKAYVE RYANTLLSVK LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE
410 420 430 440 450
NDRVVAVGYI NEAIDEGNPL RTLETLLLPT ANISDVDPAH AQHYQDVLYH
460 470 480 490 500
AKSQKLGDSE SVSKVLWLDE IQQAVDDANV DEDRAKQWVT LVVDVNQCLE
510 520 530 540 550
GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSDGSW
560 570 580 590 600
LKLNLHKKYD YYYNTDSKES SWVTPESCLY KESWLTGKEI EDIIEEVTVG
610 620 630 640 650
YIRENIWSAS EELLLRFQAT SSGPILREEF EARKSFLHEQ EENVVKIQAF
660 670 680 690 700
WKGYKQRKEY MHRRQTFIDN TDSIVKIQSW FRMATARKSY LSRLQYFRDH
710 720 730 740 750
NNEIVKIQSL LRANKARDDY KTLVGSENPP LTVIRKFVYL LDQSDLDFQE
760 770 780 790 800
ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHSK
810 820 830 840 850
KLNKKKGGEM EILNNTDNQG IKSLSKERRK TLETYQQLFY LLQTNPLYLA
860 870 880 890 900
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK
910 920 930 940 950
VDQVQDIVTG NPTVIKMVAS FNRGARGQNT LRQLLAPVVK EIIDDKSLII
960 970 980 990 1000
NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN
1010 1020 1030 1040 1050
LRRVTDKVLN SIISSLDLLP YGLRYIAKVL KNSIHEKFPD ATEDELLKIV
1060 1070 1080 1090 1100
GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSDQRRNLGS VAKVLQHAAS
1110 1120 1130 1140 1150
NKLFEGENEH LSSMNNYLSE TYQEFRKYFK EACNVPEPEE KFNMDKYTDL
1160 1170 1180 1190 1200
VTVSKPVIYI SIEEIISTHS LLLEHQDAIA PEKNDLLSEL LGSLGEVPTV
1210 1220 1230 1240 1250
ESFLGEGAVD PNDPNKANTL SQLSKTEISL VLTSKYDIED GEAIDSRSLM
1260 1270 1280 1290 1300
IKTKKLIIDV IRNQPGNTLT EILETPATAQ QEVDHATDMV SRAMIDSRTP
1310 1320 1330 1340 1350
EEMKHSQSMI EDAQLPLEQK KRKIQRNLRT LEQTGHVSSE NKYQDILNEI
1360 1370 1380 1390 1400
AKDIRNQRIY RKLRKAELAK LQQTLNALNK KAAFYEEQIN YYDTYIKTCL

DN
Length:1,402
Mass (Da):160,251
Last modified:March 3, 2009 - v1
Checksum:i0DF41EA5BE56239A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1402 – 14021Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302510 mRNA. Translation: BAH13732.1.
RefSeqiNP_001272389.1. NM_001285460.1.
NP_001272390.1. NM_001285461.1.
NP_006624.2. NM_006633.3.
UniGeneiHs.291030.

Genome annotation databases

GeneIDi10788.
KEGGihsa:10788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302510 mRNA. Translation: BAH13732.1.
RefSeqiNP_001272389.1. NM_001285460.1.
NP_001272390.1. NM_001285461.1.
NP_006624.2. NM_006633.3.
UniGeneiHs.291030.

3D structure databases

ProteinModelPortaliB7Z7U6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB7Z7U6. 1 interaction.
STRINGi9606.ENSP00000274364.

Proteomic databases

PaxDbiB7Z7U6.
PeptideAtlasiB7Z7U6.
PRIDEiB7Z7U6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10788.
KEGGihsa:10788.

Organism-specific databases

CTDi10788.

Phylogenomic databases

eggNOGiKOG2128. Eukaryota.
COG5261. LUCA.
HOGENOMiHOG000004842.
HOVERGENiHBG052143.
KOiK05767.

Miscellaneous databases

GenomeRNAii10788.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.10.506.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR000048. IQ_motif_EF-hand-BS.
IPR000593. RasGAP_C.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00612. IQ. 2 hits.
PF00616. RasGAP. 1 hit.
PF03836. RasGAP_C. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00015. IQ. 3 hits.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48350. SSF48350. 2 hits.
PROSITEiPS50021. CH. 1 hit.
PS50096. IQ. 3 hits.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z7U6_HUMAN
AccessioniPrimary (citable) accession number: B7Z7U6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: July 6, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.