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Protein

Tyrosine-protein kinase receptor

Gene

NTRK3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:NTRK3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140538.16
HGNCiHGNC:8033 NTRK3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei332 – 355HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140538

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotation

Proteomic databases

PeptideAtlasiB7Z7U4

Expressioni

Gene expression databases

BgeeiENSG00000140538

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 202Ig-likeInterPro annotationAdd BLAST91
Domaini440 – 617Protein kinaseInterPro annotationAdd BLAST178

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1026 Eukaryota
ENOG410YGKQ LUCA
GeneTreeiENSGT00760000118818
HOVERGENiHBG056735

Family and domain databases

Gene3Di2.60.40.102 hits
3.80.10.101 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR013151 Immunoglobulin
IPR011009 Kinase-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR031635 NTRK_C2
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR020446 Tyr_kin_neurotrophic_rcpt_3
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR020777 Tyr_kinase_NGF_rcpt
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00047 ig, 1 hit
PF13855 LRR_8, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF16920 TPKR_C2, 1 hit
PRINTSiPR01939 NTKRECEPTOR
PR01942 NTKRECEPTOR3
PR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00082 LRRCT, 1 hit
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

Sequencei

Sequence statusi: Complete.

B7Z7U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELYTGLQKL TIKNSGLRSI QPRAFAKNPH LRYINLSSNR LTTLSWQLFQ
60 70 80 90 100
TLSLRELQLE QNFFNCSCDI RWMQLWQEQG EAKLNSQNLY CINADGSQLP
110 120 130 140 150
LFRMNISQCD LPEISVSHVN LTVREGDNAV ITCNGSGSPL PDVDWIVTGL
160 170 180 190 200
QSINTHQTNL NWTNVHAINL TLVNVTSEDN GFTLTCIAEN VVGMSNASVA
210 220 230 240 250
LTVYYPPRVV SLEEPELRLE HCIEFVVRGN PPPTLHWLHN GQPLRESKII
260 270 280 290 300
HVEYYQEGEI SEGCLLFNKP THYNNGNYTL IAKNPLGTAN QTINGHFLKE
310 320 330 340 350
PFPESTDNFI LFDEVSPTPP ITVTHKPEED TFGVSIAVGL AAFACVLLVV
360 370 380 390 400
LFVMINKYGR RSKFGMKGPV AVISGEEDSA SPLHHINHGI TTPSSLDAGP
410 420 430 440 450
DTVVIGMTRI PVIENPQYFR QGHNCHKPDT YVQHIKRRDI VLKRELGEGA
460 470 480 490 500
FGKVFLAECY NLSPTKDKML VAVKALKDPT LAARKDFQRE AELLTNLQHE
510 520 530 540 550
HIVKFYGVCG DGDPLIMVFE YMKHGDLNKF LRAHGPDAMI LVDGQPRQAK
560 570 580 590 600
GELGLSQMLH IASQIASGMV YLASQHFVHR DLATRNCLVG ANLLVKIGDF
610
GMSRDVYSTD YYRVVQA
Length:617
Mass (Da):69,020
Last modified:March 3, 2009 - v1
Checksum:iE34D5A963FFB1CB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009711 Genomic DNA No translation available.
AC011966 Genomic DNA No translation available.
AC021677 Genomic DNA No translation available.
AK302504 mRNA Translation: BAH13730.1
RefSeqiNP_001307064.1, NM_001320135.1
UniGeneiHs.185701
Hs.410969
Hs.706364

Genome annotation databases

EnsembliENST00000542733; ENSP00000437773; ENSG00000140538
GeneIDi4916
UCSCiuc010upl.1 human

Similar proteinsi

Entry informationi

Entry nameiB7Z7U4_HUMAN
AccessioniPrimary (citable) accession number: B7Z7U4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported