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Protein
Submitted name:

Eukaryotic peptide chain release factor subunit 1

Gene

ETF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic peptide chain release factor subunit 1Imported
Submitted name:
cDNA FLJ56175, highly similar to Eukaryotic peptide chain release factor subunit1Imported
Gene namesi
Name:ETF1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:3477. ETF1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiB7Z7P8.

Expressioni

Gene expression databases

ExpressionAtlasiB7Z7P8. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353741.

Structurei

3D structure databases

SMRiB7Z7P8. Positions 16-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 127127eRF1_1InterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0688. Eukaryota.
COG1503. LUCA.
GeneTreeiENSGT00390000009004.
HOGENOMiHOG000224681.
HOVERGENiHBG005602.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
3.30.960.10. 1 hit.
InterProiIPR005140. eRF1_1_Pelota.
IPR005141. eRF1_2.
IPR005142. eRF1_3.
IPR029064. L30e-like.
IPR004403. Peptide_chain-rel_eRF1/aRF1.
IPR024049. Release_factor_eRF1/aRF1_N.
[Graphical view]
PANTHERiPTHR10113. PTHR10113. 1 hit.
PfamiPF03463. eRF1_1. 1 hit.
PF03464. eRF1_2. 1 hit.
PF03465. eRF1_3. 1 hit.
[Graphical view]
SMARTiSM01194. eRF1_1. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF55481. SSF55481. 1 hit.
TIGRFAMsiTIGR03676. aRF1/eRF1. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z7P8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQDVLNCTE GPIHSNGTSM ISLIIPPKDQ ISRVAKMLAD EFGTASNIKS
60 70 80 90 100
RVNRLSVLGA ITSVQQRLKL YNKVPPNGLV VYCGTIVTEE GKEKKVNIDF
110 120 130 140 150
EPFKPINTSL YLCDNKFHTE ALTALLSDDS KFGFIVIDGS GALFGTLQGN
160 170 180 190 200
TREVLHKFTV DLPKKHGRGG QSALRFARLR MEKRHNYVRK VAETAVQLFI
210 220 230 240 250
SGDKVNVAGL VLAGSADFKT ELSQSDMFDQ RLQSKVLKLV DISYGGENGF
260 270 280 290 300
NQAIELSTEV LSNVKFIQEK KLIGRYFDEI SQDTGKYCFG VEDTLKALEM
310 320 330 340 350
GAVEILIVYE NLDIMRYVLH CQGTEEEKIL YLTPEQEKDK SHFTDKETGQ
360 370 380 390 400
EHELIESMPL LEWFANNYKK FGATLEIVTD KSQEGSQFVK GFGGIGGILR
410 420
YRVDFQGMEY QGGDDEFFDL DDY
Length:423
Mass (Da):47,476
Last modified:March 3, 2009 - v1
Checksum:i2F927D1E6A45A3E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011385 Genomic DNA. No translation available.
AC113403 Genomic DNA. No translation available.
AK302364 mRNA. Translation: BAH13684.1.
RefSeqiNP_001269114.1. NM_001282185.1.
NP_001278903.1. NM_001291974.1.
UniGeneiHs.483494.

Genome annotation databases

EnsembliENST00000503014; ENSP00000422203; ENSG00000120705.
GeneIDi2107.
UCSCiuc011cyv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011385 Genomic DNA. No translation available.
AC113403 Genomic DNA. No translation available.
AK302364 mRNA. Translation: BAH13684.1.
RefSeqiNP_001269114.1. NM_001282185.1.
NP_001278903.1. NM_001291974.1.
UniGeneiHs.483494.

3D structure databases

SMRiB7Z7P8. Positions 16-423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353741.

Proteomic databases

EPDiB7Z7P8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000503014; ENSP00000422203; ENSG00000120705.
GeneIDi2107.
UCSCiuc011cyv.4. human.

Organism-specific databases

CTDi2107.
HGNCiHGNC:3477. ETF1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0688. Eukaryota.
COG1503. LUCA.
GeneTreeiENSGT00390000009004.
HOGENOMiHOG000224681.
HOVERGENiHBG005602.

Miscellaneous databases

ChiTaRSiETF1. human.
GenomeRNAii2107.

Gene expression databases

ExpressionAtlasiB7Z7P8. baseline and differential.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
3.30.960.10. 1 hit.
InterProiIPR005140. eRF1_1_Pelota.
IPR005141. eRF1_2.
IPR005142. eRF1_3.
IPR029064. L30e-like.
IPR004403. Peptide_chain-rel_eRF1/aRF1.
IPR024049. Release_factor_eRF1/aRF1_N.
[Graphical view]
PANTHERiPTHR10113. PTHR10113. 1 hit.
PfamiPF03463. eRF1_1. 1 hit.
PF03464. eRF1_2. 1 hit.
PF03465. eRF1_3. 1 hit.
[Graphical view]
SMARTiSM01194. eRF1_1. 1 hit.
[Graphical view]
SUPFAMiSSF55315. SSF55315. 1 hit.
SSF55481. SSF55481. 1 hit.
TIGRFAMsiTIGR03676. aRF1/eRF1. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
  5. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "N-terminome analysis of the human mitochondrial proteome."
    Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.
    Proteomics 15:2519-2524(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiB7Z7P8_HUMAN
AccessioniPrimary (citable) accession number: B7Z7P8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 8, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.