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B7Z7N6

- B7Z7N6_HUMAN

UniProt

B7Z7N6 - B7Z7N6_HUMAN

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Protein
Submitted name:

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

Gene
PDK1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of acetyl-CoA biosynthetic process from pyruvate Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Keywords - Ligandi

PyruvateImported

Names & Taxonomyi

Protein namesi
Submitted name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrialImported
Submitted name:
cDNA FLJ51565, highly similar to Pyruvate dehydrogenase (lipoamide) kinase isozyme 1 (EC 2.7.11.2)Imported
Gene namesi
Name:PDK1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:8809. PDK1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial pyruvate dehydrogenase complex Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliB7Z7N6.
SMRiB7Z7N6. Positions 1-347.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG000511.

Family and domain databases

Gene3Di1.20.140.20. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR018955. BCDHK/PDK_N.
IPR003594. HATPase_ATP-bd.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view]
PfamiPF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMiSSF55874. SSF55874. 1 hit.
SSF69012. SSF69012. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z7N6-1 [UniParc]FASTAAdd to Basket

« Hide

MFLRQELPVR LANIMKEISL LPDNLLRTPS VQLVQSWYIQ SLQELLDFKD    50
KSAEDAKAIY DFTDTVIRIR NRHNDVIPTM AQGVIEYKES FGVDPVTSQN 100
VQYFLDRFYM SRISIRMLLN QHSLLFGGKG KGSPSHRKHI GSINPNCNVL 150
EVIKDGYENA RRLCDLYYIN SPELELEELN AKSPGQPIQV VYVPSHLYHM 200
VFELFKNAMR ATMEHHANRG VYPPIQVHVT LGNEDLTVKM SDRGGGVPLR 250
KIDRLFNYMY STAPRPRVET SRAVPLAGFG YGLPISRLYA QYFQGDLKLY 300
SLEGYGTDAV IYIKALSTDS IERLPVYNKA AWKHYNTNHE ADDWCVPSRE 350
PKDMTTFRSA 360
Length:360
Mass (Da):41,303
Last modified:March 3, 2009 - v1
Checksum:i4B86ADECF096D0F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC018712 Genomic DNA. No translation available.
AC093818 Genomic DNA. No translation available.
AK302321 mRNA. Translation: BAH13672.1.
UniGeneiHs.470633.
Hs.733780.

Genome annotation databases

EnsembliENST00000543905; ENSP00000438567; ENSG00000152256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC018712 Genomic DNA. No translation available.
AC093818 Genomic DNA. No translation available.
AK302321 mRNA. Translation: BAH13672.1 .
UniGenei Hs.470633.
Hs.733780.

3D structure databases

ProteinModelPortali B7Z7N6.
SMRi B7Z7N6. Positions 1-347.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000543905 ; ENSP00000438567 ; ENSG00000152256 .

Organism-specific databases

HGNCi HGNC:8809. PDK1.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG000511.

Miscellaneous databases

ChiTaRSi Pdk1. human.
NextBioi 35480274.

Family and domain databases

Gene3Di 1.20.140.20. 1 hit.
3.30.565.10. 1 hit.
InterProi IPR018955. BCDHK/PDK_N.
IPR003594. HATPase_ATP-bd.
IPR005467. Sig_transdc_His_kinase_core.
[Graphical view ]
Pfami PF10436. BCDHK_Adom3. 1 hit.
PF02518. HATPase_c. 1 hit.
[Graphical view ]
SMARTi SM00387. HATPase_c. 1 hit.
[Graphical view ]
SUPFAMi SSF55874. SSF55874. 1 hit.
SSF69012. SSF69012. 1 hit.
PROSITEi PS50109. HIS_KIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB7Z7N6_HUMAN
AccessioniPrimary (citable) accession number: B7Z7N6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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