Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B7Z7G9

- B7Z7G9_HUMAN

UniProt

B7Z7G9 - B7Z7G9_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glucosylceramidase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.UniRule annotation

GO - Molecular functioni

  1. glucosylceramidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. sphingolipid metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolismUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
GlucosylceramidaseUniRule annotation (EC:3.2.1.45UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. lysosomal membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei8244. Hom s Glucocerebrosidase.

PTM / Processingi

Proteomic databases

PRIDEiB7Z7G9.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliB7Z7G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG002285.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11069. PTHR11069. 1 hit.
PfamiPF02055. Glyco_hydro_30. 1 hit.
[Graphical view]
PRINTSiPR00843. GLHYDRLASE30.
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

B7Z7G9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLRGWSFQV LPERNATYCD SFDPPTFPAL GTFSRYESTR SGRRMELSMG
60 70 80 90 100
PIQANHTGTG LLLTLQPEQK FQKVKGFGGA MTDAAALNIL ALSPPAQNLL
110 120 130 140 150
LKSYFSEEGI GYNIIRVPMA SCDFSIRTYT YADTPDDFQL HNFSLPEEDT
160 170 180 190 200
KLKIPLIHRA LQLAQRPVSL LASPWTSPTW LKTNGAVNGK GSLKGQPGDI
210 220 230 240 250
YHQTWARYFV KFLDAYAEHK LQFWAVTAEN EPSAGLLSGY PFQCLGFTPE
260 270 280 290 300
HQRDFIARDL GPTLANSTHH NVRLLMLDDQ RLLLPHWAKV VLTDPEAAKY
310 320 330 340 350
VHGIAVHWYL DFLAPAKATL GETHRLFPNT MLFASEACVG SKFWEQSVRL
360 370 380 390 400
GSWDRGMQYS HSIITNLLYH VVGWTDWNLA LNPEGGPNWV RNFVDSPIIV
410 420 430 440 450
DITKDTFYKQ PMFYHLGHFS KFIPEGSQRV GLVASQKNDL DAVALMHPDG
460 470 480 490
SAVVVVLNRS SKDVPLTIKD PAVGFLETIS PGYSIHTYLW RRQ
Length:493
Mass (Da):55,401
Last modified:March 3, 2009 - v1
Checksum:i394AB7550943E9A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302000 mRNA. Translation: BAH13605.1.
UniGeneiHs.282997.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302000 mRNA. Translation: BAH13605.1 .
UniGenei Hs.282997.

3D structure databases

ProteinModelPortali B7Z7G9.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi B7Z7G9.

Protein family/group databases

Allergomei 8244. Hom s Glucocerebrosidase.

Proteomic databases

PRIDEi B7Z7G9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG002285.

Miscellaneous databases

NextBioi 35480226.

Family and domain databases

Gene3Di 2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR013780. Glyco_hydro_13_b.
IPR001139. Glyco_hydro_30.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR11069. PTHR11069. 1 hit.
Pfami PF02055. Glyco_hydro_30. 1 hit.
[Graphical view ]
PRINTSi PR00843. GLHYDRLASE30.
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "NEDO human cDNA sequencing project focused on splicing variants."
    Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.
    , Sugano S., Nomura N., Isogai T.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: TestisImported.

Entry informationi

Entry nameiB7Z7G9_HUMAN
AccessioniPrimary (citable) accession number: B7Z7G9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.