ID   B7Z7D2_HUMAN            Unreviewed;       391 AA.
AC   B7Z7D2;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=Lysosomal acid phosphatase {ECO:0000256|ARBA:ARBA00039422};
DE            EC=3.1.3.2 {ECO:0000256|ARBA:ARBA00012646};
GN   Name=ACP2 {ECO:0000313|Ensembl:ENSP00000432205.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH13568.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000432205.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|EMBL:BAH13568.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:BAH13568.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [4] {ECO:0000313|Ensembl:ENSP00000432205.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000256|ARBA:ARBA00004227}.
CC       Lysosome membrane {ECO:0000256|ARBA:ARBA00037852}; Single-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00037852}; Lumenal side
CC       {ECO:0000256|ARBA:ARBA00037852}.
CC   -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC       {ECO:0000256|ARBA:ARBA00005375}.
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DR   EMBL; AC018410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK301860; BAH13568.1; -; mRNA.
DR   RefSeq; NP_001289419.1; NM_001302490.1.
DR   ProteomicsDB; 6853; -.
DR   Antibodypedia; 26620; 120 antibodies from 24 providers.
DR   DNASU; 53; -.
DR   Ensembl; ENST00000527256.7; ENSP00000432205.1; ENSG00000134575.13.
DR   GeneID; 53; -.
DR   UCSC; uc010rhf.3; human.
DR   CTD; 53; -.
DR   HGNC; HGNC:123; ACP2.
DR   NIAGADS; ENSG00000134575; -.
DR   VEuPathDB; HostDB:ENSG00000134575; -.
DR   GeneTree; ENSGT00940000158446; -.
DR   OrthoDB; 5489935at2759; -.
DR   BioGRID-ORCS; 53; 12 hits in 1168 CRISPR screens.
DR   ChiTaRS; ACP2; human.
DR   GenomeRNAi; 53; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000134575; Expressed in right lobe of liver and 197 other cell types or tissues.
DR   GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd07061; HP_HAP_like; 1.
DR   Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR   InterPro; IPR033379; Acid_Pase_AS.
DR   InterPro; IPR000560; His_Pase_clade-2.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR   PANTHER; PTHR11567:SF180; LYSOSOMAL ACID PHOSPHATASE; 1.
DR   Pfam; PF00328; His_Phos_2; 1.
DR   SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR   PROSITE; PS00778; HIS_ACID_PHOSPHAT_2; 1.
PE   1: Evidence at protein level;
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|EPD:B7Z7D2,
KW   ECO:0007829|MaxQB:B7Z7D2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..391
FT                   /note="Lysosomal acid phosphatase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014085666"
FT   TRANSMEM        349..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   391 AA;  44511 MW;  AAC4A82797E28E70 CRC64;
     MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLEG MLQHWELGQA LRQRYHGFLN
     TSYHRQEVYV RSTDFDRTLM SAEANLAGLF PPNGMQRFNP NISWQPIPVH TVPITEDRLL
     KFPLGPCPRY EQLQNETRQT PEYQNESSRN AQFLDMVANE TGLTDLTLET VWNVYDTLFC
     EQTHGLRLPP WASPQTMQRL SRLKDFSFRF LFGIYQQAEK ARLQGGVLLA QIRKNLTLMA
     TTSQLPKLLV YSAHDTTLVA LQMALDVYNG EQAPYASCHI FELYQEDSGN FSVEMYFRNE
     SDKAPWPLSL PGCPHRCPLQ DFLRLTEPVV PKDWQQECQL ASGPADTEVI VALAVCGSIL
     FLLIVLLLTV LFRMQAQPPG YRHVADGEDH A
//