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Protein
Submitted name:

Lysosomal acid phosphatase

Gene

ACP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Lysosomal acid phosphataseImported
Submitted name:
cDNA FLJ51131, highly similar to Lysosomal acid phosphatase (EC 3.1.3.2)Imported
Gene namesi
Name:ACP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:123. ACP2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei349 – 372HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000134575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_500764488831 – 391Sequence analysisAdd BLAST361

Proteomic databases

MaxQBiB7Z7D2.
PeptideAtlasiB7Z7D2.
PRIDEiB7Z7D2.

Expressioni

Gene expression databases

BgeeiENSG00000134575.
ExpressionAtlasiB7Z7D2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB7Z7D2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000062956.
HOVERGENiHBG002203.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7Z7D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKRSGWSR AALLQLLLGV NLVVMPPTRA RSLRFVTLEG MLQHWELGQA
60 70 80 90 100
LRQRYHGFLN TSYHRQEVYV RSTDFDRTLM SAEANLAGLF PPNGMQRFNP
110 120 130 140 150
NISWQPIPVH TVPITEDRLL KFPLGPCPRY EQLQNETRQT PEYQNESSRN
160 170 180 190 200
AQFLDMVANE TGLTDLTLET VWNVYDTLFC EQTHGLRLPP WASPQTMQRL
210 220 230 240 250
SRLKDFSFRF LFGIYQQAEK ARLQGGVLLA QIRKNLTLMA TTSQLPKLLV
260 270 280 290 300
YSAHDTTLVA LQMALDVYNG EQAPYASCHI FELYQEDSGN FSVEMYFRNE
310 320 330 340 350
SDKAPWPLSL PGCPHRCPLQ DFLRLTEPVV PKDWQQECQL ASGPADTEVI
360 370 380 390
VALAVCGSIL FLLIVLLLTV LFRMQAQPPG YRHVADGEDH A
Length:391
Mass (Da):44,511
Last modified:March 3, 2009 - v1
Checksum:iAAC4A82797E28E70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018410 Genomic DNA. No translation available.
AK301860 mRNA. Translation: BAH13568.1.
RefSeqiNP_001289419.1. NM_001302490.1.
UniGeneiHs.532492.

Genome annotation databases

EnsembliENST00000527256; ENSP00000432205; ENSG00000134575.
GeneIDi53.
UCSCiuc010rhf.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018410 Genomic DNA. No translation available.
AK301860 mRNA. Translation: BAH13568.1.
RefSeqiNP_001289419.1. NM_001302490.1.
UniGeneiHs.532492.

3D structure databases

ProteinModelPortaliB7Z7D2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiB7Z7D2.
PeptideAtlasiB7Z7D2.
PRIDEiB7Z7D2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527256; ENSP00000432205; ENSG00000134575.
GeneIDi53.
UCSCiuc010rhf.3. human.

Organism-specific databases

CTDi53.
HGNCiHGNC:123. ACP2.
OpenTargetsiENSG00000134575.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000062956.
HOVERGENiHBG002203.

Miscellaneous databases

ChiTaRSiACP2. human.
GenomeRNAii53.

Gene expression databases

BgeeiENSG00000134575.
ExpressionAtlasiB7Z7D2. baseline and differential.

Family and domain databases

CDDicd07061. HP_HAP_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
InterProiIPR033379. Acid_Pase_AS.
IPR000560. His_Pase_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB7Z7D2_HUMAN
AccessioniPrimary (citable) accession number: B7Z7D2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.